Clinical trials
Metformin clinical trials
Below are recruiting metformin clinical trials, each written for real people, not researchers. We’re tracking 148 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05243654RecruitingPhase 2
Metformin add-on for newly diagnosed leprosy treatment
This Phase 2 trial tests whether adding metformin to standard leprosy treatment (multidrug therapy, or MDT) helps people with multibacillary leprosy recover better and remain tolerable over 48 weeks. Participants also get monitored closely for side effects and safety issues.
Tangerang, BantenAges 18–65 - NCT06707012RecruitingPhase 4
Metformin plus antidepressants for depression in obesity
This trial tests whether adding metformin (a diabetes medicine) to usual antidepressant treatment can help improve depression in people who are overweight or obese. It is for adults age 18–44 who are newly diagnosed with depression and do not have diabetes.
Karachi, SindhAges 18–45 - NCT06463743RecruitingPhase 2
Metformin for aging people with MS
This study tests whether metformin, a common diabetes drug, can help people with multiple sclerosis (MS) as they age. It may be used alone or added to your current MS treatment, and the goal is to see if it slows down aging-related changes in MS.
Buffalo, New YorkAges 55–75 - NCT06445946RecruitingPhase 4
Metformin vs insulin for gestational diabetes
This study compares two common medicines (metformin pills and insulin shots) to see which works better for controlling blood sugar in pregnant women with gestational diabetes. The goal is to find the best treatment for both mom and baby, now and in the long term.
Tuscaloosa, AlabamaAges 18 years+ - NCT06429007Enrolling by invitationPhase 1
Metformin for infants after brain injury from HIE
This trial tests whether metformin, a common diabetes medicine, can help heal brain injury in infants who had HIE (lack of oxygen at birth) and were treated with cooling. It aims to see if the drug is safe and possible to give to babies between 3 and 6 months old.
Boston, MassachusettsAges 3 months–6 months - NCT04121468RecruitingPhase 1/Phase 2
Metformin trial for vision nerve recovery in young people with MS
This study tests whether metformin can help “reset” damaged nerve cells in the brain and improve vision-related nerve problems in children and young adults with multiple sclerosis. Participants are assigned to metformin or a comparison treatment in a blinded (not everyone knows which) study.
Toronto, OntarioAges 10–25 - NCT06231758RecruitingPhase 3
Metformin for knee osteoarthritis: a phase 3 trial
This study tests whether metformin, a common diabetes medication, can help reduce pain and improve knee function in people with knee osteoarthritis. It may offer a new treatment option for those with moderate knee OA.
Damietta, New DamiettaAges 30–60 - NCT06185179RecruitingEarly Phase 1
Metformin for muscle recovery in older adults
This study tests whether a common diabetes medicine called metformin can help your muscles recover faster after a minor injury. You may qualify if you are 60 or older, generally healthy, and not taking certain medicines.
Salt Lake City, UtahAges 60 years+ - NCT06120881RecruitingEarly Phase 1
Finding the Right Metformin Dose for Teens with Type 2 Diabetes
This study looks at how to give the right dose of metformin to young people with type 2 diabetes. If you join, you will wear a continuous glucose monitor for 6 weeks to help researchers find the best dose for you.
Oakland, CaliforniaAges 10–21 - NCT06090227RecruitingPhase 1/Phase 2
Metformin for FSGS: A phase 1/2 trial
This trial tests whether the diabetes drug metformin can help people with a kidney disease called FSGS, by activating a cell-protecting pathway. Participants will take metformin or a placebo along with their usual steroid treatment.
New Haven, ConnecticutAges 18–80 - NCT04578652RecruitingPhase 3
Test fiber plus metformin for teen weight and insulin resistance
This trial studies whether adding fiber to metformin helps teens with severe obesity and insulin resistance improve how their bodies handle sugar. You might consider it if you’re a teen who isn’t yet diagnosed with type 2 diabetes and meets the specific lab and health criteria.
Edmonton, AlbertaAges 12–18 - NCT06033131RecruitingPhase 3
Metformin to help prolong pregnancy in preterm preeclampsia
This trial tests whether metformin, a common diabetes medication, can help women with preeclampsia stay pregnant longer before delivery. If you have been diagnosed with preeclampsia and your doctors are monitoring you without immediate delivery, this study might be an option.
HelsinkiAges 18 years+ - NCT06030622RecruitingPhase 1/Phase 2
Treatment for advanced pancreatic cancer after standard therapy
This trial tests a combination of three medicines to see if they can slow down or shrink pancreatic cancer that has not responded to previous treatments or has come back. It might help if you are generally healthy and your cancer is advanced.
Brooklyn, New YorkAges 18 years+ - NCT05426044RecruitingPhase 2
Metformin to protect the optic nerve in glaucoma
This study tests whether metformin can slow damage to the optic nerve in people with glaucoma. It uses eye scans and vision tests to look for changes over time, aiming to help preserve sight.
Wong Chuk HangAges 18 years+ - NCT04945148RecruitingPhase 2
Metformin plus radiation and chemo for glioblastoma subtype
This Phase 2 study tests whether adding metformin to standard radiation and temozolomide (chemo) can improve outcomes for people with newly diagnosed glioblastoma of a specific metabolic subtype. It aims to see if this combination is safer and more effective than standard treatment alone.
Suresnes, Hauts de SeineAges 18 years+ - NCT05532813RecruitingPhase 3
Metformin for adult myotonic dystrophy type 1 muscle weakness
This Phase 3 trial tests whether metformin can improve symptoms and safety in adults with genetically confirmed myotonic dystrophy type 1 (DM1). It may help reduce muscle problems, but you must meet specific walking, breathing, heart, and kidney requirements.
GarchesAges 18–70 - NCT05900466RecruitingPhase 2
Metformin for fibromyalgia symptom relief
This study tests whether metformin, a diabetes medicine, can reduce fibromyalgia symptoms. If you have fibromyalgia and can take pills safely, you may be able to join and help answer whether metformin can help.
Salt Lake City, UtahAges 18–75 - NCT05744479RecruitingPhase 4
Metformin to reduce weight gain from antipsychotic medicines
This trial tests whether metformin can help adults with intellectual disability who gained weight from long-term antipsychotic medicines. If you qualify, you may be assigned metformin to improve weight and related health measures.
Toronto, OntarioAges 16–65 - NCT05727761RecruitingPhase 2
Pioglitazone plus metformin for high-risk mouth lesions
This trial studies whether a two-medicine diabetes drug combination can reduce or control risky early changes in certain mouth and throat lesions. You may be asked for small tissue samples (biopsies) before and after 12 weeks to see how the lesions respond.
Minneapolis, MinnesotaAges 18 years+ - NCT04670666RecruitingPhase 3
Study of Madalena for type 2 diabetes not controlled
This Phase 3 study tests Madalena to improve blood sugar control in adults with type 2 diabetes that hasn’t met targets despite diet, exercise, and diabetes medicines. You may join if your recent blood sugar tests and body size fall within specific ranges and you don’t have key medical exclusions.
Hortolândia, São PauloAges 18 years+ - NCT05515978RecruitingEarly Phase 1
Metformin study for prostate cancer patients with weight or sugar issues
This early-phase study tests whether metformin can help prostate cancer patients who have higher body weight and/or early blood sugar problems. You would be screened for eligibility using your medical record, and the study looks mainly at your current health factors and medicines.
Aurora, ColoradoAges 18 years+ - NCT05445791RecruitingPhase 3
Metformin plus targeted lung cancer drugs for EGFR-mutated cancer
This Phase 3 study tests whether adding metformin to standard targeted medicines (tyrosine kinase inhibitors) helps people with EGFR-mutated non-small cell lung cancer. It’s meant for people who haven’t already had EGFR-targeted treatment and who have healthy enough labs and organs to safely take the study medicines.
Mexico CityAges 18 years+ - NCT05414409RecruitingPhase 2
Gut microbiome study in young people with type 1 diabetes
This Phase 2 study looks at the gut microbiome (the bacteria in your intestines) in youth with type 1 diabetes, and how metformin may work differently through the gut. It may help researchers understand mechanisms and future treatment options.
Indianapolis, IndianaAges 11–18 - NCT05230758RecruitingPhase 3
Metformin trial for brain tumor survivors’ brain and behavior
This Phase 3 study tests whether metformin can improve brain function, behavior, and thinking in children and teens who were treated for certain brain tumors. You may be able to join if you meet age, time-since-treatment, language, and health/lab safety requirements.
New Lambton Heights, New South WalesAges 7–21
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Common questions
- Are there clinical trials for metformin?
- Yes. Clin2 currently lists 148 recruiting metformin studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a metformin trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a metformin trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.