Clinical trials
Metformin clinical trials
Below are recruiting metformin clinical trials, each written for real people, not researchers. We’re tracking 148 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06064669Recruiting
Metformin for healthy live birth in women with prediabetes
This study tests if metformin, a drug that helps control blood sugar, can improve the chance of a healthy live birth in women with prediabetes who are doing in vitro fertilization (IVF). It aims to see if treating prediabetes before and during early pregnancy leads to better outcomes.
Jinan, ShandongAges 20–40 - NCT06863532Recruiting
Comparing two add-on treatments for type 2 diabetes
This trial compares adding a new pill (cofrogliptin) to increasing your current metformin dose, for people whose blood sugar is still too high despite taking an SGLT2 inhibitor and a low dose of metformin. The goal is to see which option works better and is safer.
Hangzhou, ZhejiangAges 18–74 - NCT06888050RecruitingPhase 4
Study of new diabetes pill versus metformin for new type 2 diabetes
This trial tests a new combination pill (henagliflozin and metformin) compared to metformin alone in people recently diagnosed with type 2 diabetes. The goal is to see which treatment works better and is safer.
Hangzhou, ZhejiangAges 18–75 - NCT05036226RecruitingPhase 1/Phase 2
COAST therapy for advanced prostate or other solid tumors
This early-phase trial tests the COAST therapy approach in people with advanced solid tumor cancers or advanced prostate cancer that has continued to grow despite standard treatments. The study aims to see how well the treatment works and whether it is safe enough to continue studying.
Charleston, South CarolinaAges 18 years+ - NCT06273072RecruitingPhase 2
Metformin for asthma in overweight adults
This trial tests whether the diabetes drug metformin can help people with asthma who are also overweight or obese. The goal is to see if it improves asthma control and reduces the need for rescue medications.
Baltimore, MarylandAges 18 years+ - NCT05469659RecruitingPhase 2
Test drug to slow kidney damage in type 2 diabetes
This Phase 2 study compares tofogliflozin to metformin to see how well they reduce urine albumin levels (a marker of kidney stress) in people with diabetic kidney disease. You might benefit if your type 2 diabetes is affecting your kidneys despite standard blood-pressure medicines.
Matsumoto, NaganoAges 20 years+ - NCT04581447RecruitingPhase 3
Metformin to help prevent diabetes returning after weight surgery
This Phase 3 study tests whether adding metformin after gastric bypass or sleeve surgery can help you stay free of diabetes for longer. It compares metformin plus standard care versus standard care alone.
AmiensAges 18–70 - NCT07452913Enrolling by invitationPhase 4
Comparing Diabetes Drug Combinations in Newly Treated Adults
This trial compares two different combinations of diabetes pills (metformin plus empagliflozin with either sitagliptin or linagliptin) in people with type 2 diabetes who have not been treated before. It aims to see which combination works better and is safer for controlling blood sugar.
Karachi, SindhAges 30–55 - NCT07307677Recruiting
Melatonin and metformin for PCOS with insulin resistance
This study tests if adding melatonin to metformin can improve insulin resistance and other health markers in women with PCOS who have insulin resistance. It compares the combination to metformin alone.
Dhaka, ShahbagAges 18–35 - NCT06459310RecruitingPhase 2
Testing metformin to slow aging in healthy men
This study tests whether metformin can help slow aging in healthy men. You might be eligible if you are a man in one of two age groups and do not have major health problems.
BeijingAges 18–65 - NCT06932874RecruitingPhase 4
Metformin for diabetes with heart disease
This trial tests a long-acting metformin pill in people with both type 2 diabetes and coronary heart disease. It aims to see if metformin can safely help control blood sugar in this specific group.
Beijing, Beijing MunicipalityAges 30–75 - NCT07019012RecruitingPhase 4
Testing a new every-2-week pill for type 2 diabetes
This study tests a new once-every-2-weeks pill (cofrogliptin) added to your current diabetes medications (metformin and dapagliflozin) compared to a daily pill (linagliptin). It may help improve blood sugar control with fewer daily pills.
Wuhan, HubeiAges 18 years+ - NCT05929495RecruitingPhase 2
Metformin added to standard treatment for newly diagnosed glioblastoma
This Phase 2 study tests whether adding metformin to the usual treatment for newly diagnosed glioblastoma (GBM) can improve outcomes. It involves taking metformin after surgery along with standard care (the Stupp protocol).
MilanAges 18 years+ - NCT06424860RecruitingPhase 1
Fish Oil, Metformin and Heart Health in PCOS
This trial tests whether fish oil and metformin can improve heart health in people with PCOS who are overweight or have high blood sugar or fats. It combines two common approaches to see if they work better together.
Edmonton, AlbertaAges 25–45 - NCT02915198RecruitingPhase 4
Metformin for prediabetes to reduce heart and blood-vessel events
This trial tests whether taking metformin in people with prediabetes can lower the chance of future heart attack, stroke, or other blood-vessel problems. You may be a good fit if you have prediabetes plus existing cardiovascular disease or significant blood-vessel disease.
Phoenix, ArizonaAges 18 years+ - NCT07770711Recruiting
Inositol and metformin with different diets for PCOS
This study compares two diet plans (Mediterranean and low-carb) along with the supplements inositol and metformin, to see which works better for weight and blood sugar control in women with PCOS and insulin resistance. It may help you manage PCOS symptoms and improve your body's response to insulin.
Diyarbakır, DiyarbakırAges 20–40 - NCT04500678RecruitingPhase 2/Phase 3
Metformin to improve immune health in HIV
This study tests whether a diabetes drug called metformin can improve the immune system and help keep the HIV virus under control in people who are already doing well on HIV treatment. If you are over 40 and have had a stable viral load for a year, this could be a way to boost your immune health.
Honolulu, HawaiiAges 40 years+ - NCT01638676RecruitingPhase 1/Phase 2
Testing vemurafenib plus metformin for BRAF-mutated melanoma
This study tests whether adding metformin to vemurafenib can shrink advanced melanoma in people with a specific gene change (BRAF V600E). It’s an early-phase trial, so the main goal is to see if the combination is safe and whether it may work better than expected.
Louisville, KentuckyAges 18 years+ - NCT02947503RecruitingPhase 3
Metformin for gestational diabetes in pregnancy outcomes
This study tests whether taking metformin during pregnancy improves outcomes for people with gestational diabetes. It may help with pregnancy health and baby outcomes compared with the study’s other diabetes care plan.
GroningenAges 18–45 - NCT04758000RecruitingPhase 2
Metformin after bone cancer treatment to prevent relapse
This Phase 2 study tests whether taking metformin after surgery and chemotherapy can reduce the risk of bone cancer coming back in people at high risk of relapse. You may be eligible if you have osteosarcoma or Ewing sarcoma that is not currently spread and you meet specific lab and health criteria.
BolognaAges 14 years+ - NCT03379909RecruitingPhase 2
Metformin taken by mouth for early bladder cancer
This trial studies whether a diabetes medicine called metformin can help prevent or control non-muscle-invasive bladder cancer inside the bladder. You would take it by mouth, and the study checks safety and whether it works.
Nijmegen, GelderlandAges 18 years+ - NCT06449833RecruitingPhase 4
Henagliflozin for liver fat in diabetes and fatty liver
This study tests whether a medicine called henagliflozin can help reduce fat in the liver for people with type 2 diabetes and non-alcoholic fatty liver disease. It may help improve liver health and blood sugar control at the same time.
Guangzhou, GuangdongAges 18–75 - NCT07802561RecruitingPhase 4
Metformin vs glyburide for gestational diabetes
This study compares two medicines, metformin and glyburide, to see which is better at controlling blood sugar in pregnant women with gestational diabetes. If you need medication to manage your blood sugar during pregnancy, this trial might help guide treatment choices.
Multan, Punjab ProvinceAges 18–45 - NCT06537843RecruitingPhase 2
Venetoclax, cytarabine and metformin for AML
This trial tests a combination of three drugs – venetoclax, cytarabine, and metformin – for adults with AML who cannot receive standard high-dose chemotherapy. It aims to see if this gentler mix can help control the leukemia with fewer side effects.
BelémAges 18 years+
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Common questions
- Are there clinical trials for metformin?
- Yes. Clin2 currently lists 148 recruiting metformin studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a metformin trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a metformin trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.