Clinical trials
Microvascular Coronary Artery Disease clinical trials
Below are recruiting microvascular coronary artery disease clinical trials, each written for real people, not researchers. We’re tracking 50 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT02582021Recruiting
Study of treatments and imaging in women with angina or HFpEF
This trial studies how heart disease affects the heart using heart imaging, and looks at people with chest pain/angina or heart failure with preserved pumping strength (HFpEF). It may help doctors better understand what’s driving symptoms and how best to evaluate these conditions.
Los Angeles, CaliforniaAges 18 years+ - NCT07761728Enrolling by invitation
Comparing two heart PET scan tracers
This study compares two types of radioactive tracers used during heart PET scans to see if one is better at detecting blocked arteries. Participation involves receiving one of the tracers during your routine scan and may help improve heart disease diagnosis.
Los Angeles, CaliforniaAges 18 years+ - NCT06681896Recruiting
Exercise rehabilitation for heart microvessel disease
This trial tests a supervised exercise program for people with chest pain caused by tiny heart blood vessel problems (microvascular dysfunction). It aims to see if exercise can improve symptoms and heart function.
BathAges 18 years+ - NCT02301663Recruiting
Stress test study of heart blood-flow issues in adults
This study tests a new kind of stress test to understand how small blood-vessel heart problems relate to heart relaxation problems in people with angina (chest pain) but no blocked arteries. It may help doctors learn better ways to diagnose and guide treatment for these conditions.
Los Angeles, CaliforniaAges 18–60 - NCT06503640Recruiting
Microvascular dysfunction in angina patients
This study tests if chest pain with clear arteries is caused by tiny heart vessel problems. It may help find better treatments for patients whose arteries look normal on angiograms.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05634031Recruiting
Study of heart vessel dysfunction seen on heart imaging
This study looks at coronary microvascular dysfunction (small blood vessel problems in the heart) using heart imaging. It may help researchers understand causes of chest tightness with activity and shortness of breath when the main heart arteries are not blocked.
New York, New YorkAges 18 years+ - NCT03479580Recruiting
Registry for coronary and small-vessel heart disease in cardiomyopathy
This study enrolls people with certain types of heart muscle diseases to learn how blocked heart arteries and tiny blood vessels affect symptoms and outcomes. It may help researchers better understand these conditions and improve future care.
La TroncheAges 18–100 - NCT04375306Recruiting
Testing a heart-pressure ratio to choose bypass surgery plan
This trial studies whether a special heart “pressure/flow ratio” test (measured during the procedure) can help doctors choose the best plan for coronary bypass surgery. It may improve how bypass targets the problem blood vessels, but only if certain heart and health factors fit the study rules.
BonheidenAges 18 years+ - NCT04606459Recruiting
Device trial for hard-to-treat heart chest pain from small vessels
This trial tests whether a small pressure-reducing device placed in a heart vein (the coronary sinus) can reduce symptoms in people with ongoing chest pain from tiny blood vessel problems. It is for angina that has not improved despite standard heart medicines, and only if special heart tests show reversible reduced blood flow.
Mainz, Rhineland-PalatinateAges 18–85 - NCT04674449Recruiting
Tests a targeted plan for people with chest pain from heart artery disease
This study aims to match people with angina (chest pain from heart artery problems) to the most helpful treatment plan based on their test results. It’s done around the time doctors are planning an invasive heart scan to look at the coronary arteries.
CorkAges 18 years+ - NCT04827498Recruiting
Testing heart blood-flow problems without clogged arteries
This study looks at how well the heart’s blood vessels work in people who have symptoms of reduced blood flow but no major artery blockage. It uses special heart tests with medicines to check how the vessels respond and may help guide better diagnosis and treatment.
MadridAges 18 years+ - NCT05272618Recruiting
Testing heart vessel dysfunction after a heart attack
This trial looks at how to assess small blood-vessel (microvascular) problems in people who had a heart attack but whose main heart arteries are not blocked. It may help doctors better find what’s driving symptoms and choose the right tests and treatments.
Gwangju, GwangjuAges 19 years+ - NCT05841199Recruiting
Study heart blood flow during fast heart rates
This study measures how well blood flows through the heart when the heart rate is increased during a heart procedure. It may help doctors better understand coronary (heart artery) blood flow and how to guide treatment when you need angiography or angioplasty.
LondonAges 18 years+ - NCT06075602Recruiting
Complex and calcified coronary artery disease: a registry study
This study watches how people with complex or calcified heart artery disease are treated (with stents or bypass surgery) and how they do over time. It aims to learn which treatments work best for tough blockages.
Lucerne, Canton of LucerneAges 18 years+ - NCT06076551Recruiting
Sex differences in small blood vessel problems of the heart
This study looks at how small blood vessels in the heart work differently in men and women who have chest pain but no major blockages in their main heart arteries. The goal is to better understand and treat these smaller vessel issues.
SeoulAges 20–80 - NCT06089577RecruitingPhase 4
Cangrelor for heart blood flow during planned stent procedure
This trial tests if cangrelor, a fast-acting blood thinner, can prevent small vessel damage during a planned stent placement in patients with stable chest pain. It may help improve blood flow to the heart muscle.
FerraraAges 18 years+ - NCT06125392Recruiting
New Definition for Small Heart Vessel Disease
This trial studies a condition where small heart vessels don't work well. It looks at new ways to define this problem using a special test that measures pressure and blood flow in a heart artery.
Mainz, Rhineland-PalatinateAges 18–90 - NCT06393478Recruiting
Southeastern Europe Microcirculation Registry
This study is collecting information about how well the tiny blood vessels in the heart work in people with chest pain. It helps doctors learn more about microcirculation problems and may lead to better treatments.
RijekaAges 18 years+ - NCT06424834RecruitingPhase 2/Phase 3
Targeted medicines for chest pain without blocked arteries
This study tests if specific heart medicines (like beta-blockers or calcium channel blockers) can help people with chest pain that is not caused by blocked arteries. It aims to treat the tiny blood vessels or spasms that may be the real cause of your pain.
Palo Alto, CaliforniaAges 18 years+ - NCT06529848Recruiting
Exercise for heart symptoms with clear arteries
This trial tests if exercise training can help people who have chest pain or shortness of breath even though their main heart arteries are not blocked. It focuses on those with small vessel disease in the heart, also known as INOCA.
CopenhagenAges 50 years+ - NCT06597851Recruiting
Insulin resistance and heart artery health: a study for chest pain patients
This study looks at how insulin resistance affects tiny heart arteries in people who have chest pain and signs of heart stress on tests, but do not have major blockages in their heart arteries. It aims to understand why some people have heart symptoms even when their main arteries appear clear.
Verona, VRAges 18 years+ - NCT06600178RecruitingPhase 1
Heart medication for women with chest pain and small vessel disease
This trial tests a diabetes medication called SGLT2 inhibitors to see if it can improve blood flow to the heart and reduce chest pain in women who have small vessel heart disease (microvascular dysfunction) but not blocked large arteries. Participants will take the medication and be monitored for symptom relief and heart function improvements.
Charlottesville, VirginiaAges 18 years+ - NCT06606821RecruitingPhase 4
Tirzepatide for heart health in people with overweight or obesity
This trial tests the weight‑loss medication tirzepatide (Mounjaro) in people who are overweight or have obesity and have stable coronary artery disease. The goal is to see if tirzepatide can reduce dangerous fatty plaque in heart arteries.
CopenhagenAges 18 years+ - NCT06699420RecruitingPhase 4
Qishenyiqi pill for small vessel heart disease
This trial tests if a Chinese herbal pill called Qishenyiqi can help people with chest pain caused by tiny heart blood vessels that are too tight. It may be an option if standard tests show your heart vessels are mostly clear but your blood flow is reduced.
Jinan, ShandongAges 40–75
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Common questions
- Are there clinical trials for microvascular coronary artery disease?
- Yes. Clin2 currently lists 50 recruiting microvascular coronary artery disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a microvascular coronary artery disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a microvascular coronary artery disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.