Clinical trials
Mild Cognitive Disorder clinical trials
Below are recruiting mild cognitive disorder clinical trials, each written for real people, not researchers. We’re tracking 312 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04804241RecruitingPhase 2
Senicapoc for early Alzheimer’s symptoms
This Phase 2 study tests whether the drug senicapoc can slow or improve symptoms in people with early Alzheimer’s disease or mild memory impairment. You would have a 50/50 chance of getting senicapoc or a placebo (inactive pill), along with regular study visits and testing.
Sacramento, CaliforniaAges 55–85 - NCT04601038RecruitingPhase 2
Testing a stress-blocking drug for early Alzheimer's risk
This study tests a new medication, CORT108297, that may help protect the brain from the harmful effects of stress in people at risk for Alzheimer's disease. It is looking for adults age 55 and older who either have mild memory problems or are healthy but have a family history, APOE4 gene, or memory concerns.
Baltimore, MarylandAges 55 years+ - NCT04396873RecruitingPhase 1
PET brain scan study of inflammation markers in neurodegeneration
This Phase 1 study tests a PET scan to measure inflammation-related changes in the brain using a medication called ketoprofen. It may help researchers understand which people with certain brain diseases could benefit from treatments aimed at inflammation.
Bethesda, MarylandAges 18–99 - NCT04482660Enrolling by invitation
PET brain scan study of tau protein in ALFA volunteers
This study uses a special PET brain scan tracer to measure “tau” protein clumps in the brain. It’s meant to better understand brain changes in people who are already part of the ALFA research program, and may help researchers connect tau levels with memory and thinking.
Barcelona, BarcelonaAges 45 years+ - NCT04240561Recruiting
Study of hearing aid results in people with Alzheimer’s dementia
This study looks at how much hearing aid outcomes vary in older adults who have Alzheimer’s dementia or mild memory problems. It may help researchers understand what hearing aids work best and for whom.
Chicago, IllinoisAges 50–90 - NCT03574207Recruiting
Brain stimulation study for memory in certain adults
This study tests a targeted, non-surgical brain stimulation method to help people with memory, especially remembering facts over time. It compares healthy adults and adults with amnestic mild cognitive impairment (aMCI), using sessions plus brain scans and memory testing.
Omaha, NebraskaAges 19 years+ - NCT03370224Enrolling by invitation
Story memory training for older adults
This study tests a memory-skills training approach (the Modified Story Memory Technique) to help older adults with aging-related memory changes. You may be asked to do memory exercises, and some people may also complete an optional brain MRI scan.
East Hanover, New JerseyAges 65 years+ - NCT03140865Recruiting
Alzheimer’s disease research core for brain and memory testing
This study group collects detailed information from people with normal memory, mild cognitive impairment, or mild Alzheimer’s disease to support Alzheimer’s research. You may need multiple visits, brain scans, and sometimes a spinal fluid sample, with strict health and medication requirements to keep results clear.
Winston-Salem, North CarolinaAges 55 years+ - NCT03174938Recruiting
BioFINDER 2 study for healthy aging and memory problems
This study uses brain scans and a spinal fluid test to better understand memory and thinking changes in different groups, from people with healthy thinking to early or established dementia. If you qualify, it may help researchers learn what’s driving these conditions and how they progress.
ÄngelholmAges 20–100 - NCT06639282RecruitingPhase 2
Testing siponimod for mild Alzheimer's dementia
This study tests if a medicine called siponimod, already used for multiple sclerosis, can help people with mild Alzheimer's dementia. You will take a pill daily and be monitored closely for safety and cognitive changes.
Phoenix, ArizonaAges 50–85 - NCT06956417Recruiting
Memory rehab after concussion
This trial tests a memory rehabilitation program for people who have had a concussion and still have memory problems. It uses a computer, tablet, or smartphone to help improve memory.
Calgary, AlbertaAges 18–59 - NCT07639606Recruiting
Mobile therapy app for mood after recent stroke
This study tests whether using a smartphone or tablet app for cognitive behavioral therapy (a type of talk therapy you do on your device) can help with anxiety and depression in the first month after a stroke. The goal is to see if this convenient, at-home approach improves how you feel during early recovery.
New York, New YorkAges 18–79 - NCT07657624Recruiting
Heart disease and memory problems risk study
This study looks at what factors might increase the risk of memory and thinking problems in people with coronary heart disease. It includes testing your memory and metabolism during a hospital stay.
Beijing, ChinaAges 18 years+ - NCT07298876Enrolling by invitation
Ultrasound for memory and sleep in early Alzheimer's
This study tests if a gentle ultrasound treatment to the brain can help improve memory and sleep quality in people with very early Alzheimer's disease. If you have mild memory issues and trouble sleeping, this low-intensity approach might be a safe option to explore.
Hong Kong, Tai Po DistrictAges 60–85 - NCT07532460Recruiting
Study of brain channels and memory in cocaine users
This research explores how certain brain chemicals (potassium channels) affect memory and thinking in people who use cocaine regularly. The study may help develop better treatments for cocaine use disorder and related thinking problems.
Zurich, Canton of ZurichAges 20–50 - NCT07282691Recruiting
Validating eye tests for mild brain injury
This study looks at eye tests for people who had a mild brain injury (mTBI) in the last 1 to 6 months. It aims to better understand and measure eye movement problems that can happen after such an injury.
Philadelphia, PennsylvaniaAges 18–35 - NCT07044596Recruiting
Non-invasive brain stimulation to slow cognitive decline
This study tests whether a gentle, non-invasive electrical stimulation can help slow memory loss or thinking problems. It is looking for healthy volunteers and people who have had a mild traumatic brain injury within the past year.
Madison, WisconsinAges 20–85 - NCT06999954Recruiting
Global survey for Shwachman-Diamond syndrome and related conditions
This trial is a global survey and registry for people with Shwachman-Diamond Syndrome and related inherited blood disorders. It aims to connect patients, families, and researchers to better understand these conditions and improve care.
Woburn, MassachusettsAges Any age - NCT06718140Enrolling by invitationPhase 1
Ultrasound for memory in mild cognitive decline
This study tests if a non-invasive ultrasound treatment can help memory in people with mild cognitive impairment (mNCD) and healthy older adults. It involves MRI scans and focused ultrasound sessions.
Charleston, South CarolinaAges 50–85 - NCT06362707RecruitingPhase 2
Fasudil trial for early Alzheimer's disease
This trial tests a medication called fasudil to see if it can help people with early Alzheimer's disease. It is for people who have early symptoms (mild cognitive impairment or mild dementia) and have biomarker evidence of Alzheimer's in their brain.
Tromsø, NordlandAges 50–100 - NCT06375265Recruiting
Sleep improvement program for older surgery patients
This trial tests a digital sleep improvement program for older adults who are about to have knee or hip replacement surgery. It aims to help you sleep better before and after surgery, which may improve your brain health and recovery.
Boston, MassachusettsAges 65 years+ - NCT05592678Recruiting
Study brain and memory test changes in Alzheimer’s or mild issues
This study looks at how well people with Alzheimer’s disease (AD) or mild cognitive impairment (MCI) perform on standardized memory/brain tests. It may help researchers understand changes over time, and whether certain types of brain signals or test results track with the condition.
San Antonio, TexasAges 65–100 - NCT06951919Recruiting
HOBSCOTCH study for memory help in MS
This trial tests a program called HOBSCOTCH to help people with MS who have memory or thinking problems. It also includes a caregiver who supports them.
Lebanon, New HampshireAges 20–75 - NCT05943834Recruiting
Voice testing to detect early memory and mood changes
This trial studies whether automated analysis of your voice and speech can help detect early signs of Alzheimer’s disease and mood (affective) problems. It may help identify changes sooner, using voice and questionnaire information from people who are cognitively healthy to very mildly affected.
NiceAges 50–100
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Common questions
- Are there clinical trials for mild cognitive disorder?
- Yes. Clin2 currently lists 312 recruiting mild cognitive disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mild cognitive disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mild cognitive disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Mild Cognitive Impairment
- Amnestic Mild Cognitive Impairment
- Cognitive Dysfunction, Cognitive Disorder
- Mild Cognitive Impairment (MCI) Amnestic
- Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
- Amnestic Mild Cognitive Disorder
- Mild Cognitive Impairment Due to Alzheimer's Disease
- Cognitive Impairment
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.