Clinical trials
Mitral Regurgitation clinical trials
Below are recruiting mitral regurgitation clinical trials, each written for real people, not researchers. We’re tracking 98 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07197736Recruiting
Improving heart ultrasound use at Columbia
This study involves cardiologists who read heart ultrasounds in Columbia's echo lab. It aims to improve how these tests are used to help patients.
New York, New YorkAges 18 years+ - NCT07726173Recruiting
Off-pump mitral valve repair through the heart
This trial tests a new way to repair a leaky mitral valve without stopping the heart or using a heart-lung machine. The surgery is done through a small cut in the heart's lower chamber. It may be an option for people with severe degenerative mitral regurgitation who are not good candidates for standard open-heart surgery.
Baltimore, MarylandAges 21 years+ - NCT05298124Recruiting
Repairing a leaking mitral valve in severe heart shock
This trial tests a catheter-based procedure to repair a leaking mitral valve in people who are in severe heart shock and need medication support. The goal is to reduce the valve leak and see if it helps patients stabilize and recover.
Rochester, MinnesotaAges 18 years+ - NCT04888247Recruiting
Testing a new mitral valve replacement for high-risk patients
This study checks whether an innovative device can safely replace a damaged mitral valve in people who are higher risk for open-heart surgery. It looks at how well the procedure and follow-up work for improving mitral leakage symptoms.
AuchenflowerAges 18 years+ - NCT06917586Recruiting
Mosaic mitral valve study for patients under 65
This study looks at long-term results in people under 65 who received a specific type of replacement heart valve (the Mosaic mitral valve) during surgery at ProMedica Toledo Hospital. It aims to understand how well the valve works over time.
Toledo, OhioAges 18–65 - NCT07503236Recruiting
Study of a new device for leaking heart valves
This trial tests a new device designed to fix a leaky mitral valve in people with heart failure. It may help you breathe easier and feel less tired if your valve leak is severe and medicines have not been enough.
Sacramento, CaliforniaAges 21 years+ - NCT04820764Recruiting
Testing a device to treat leaking mitral valve
This study looks at how long a new mitral valve treatment/device can stay working in people with moderate-to-severe or severe mitral valve leak. It may help avoid or delay surgery for people considered higher risk for mitral valve repair.
Thousand Oaks, CaliforniaAges 18 years+ - NCT05040074Recruiting
Transcatheter repair for leaking mitral valve in high-risk patients
This trial studies a minimally invasive device meant to fix a badly leaking mitral valve (mitral regurgitation) without open-heart surgery. It may be an option if you’re considered too high-risk for standard surgery and your heart anatomy fits the device.
Shenyang, LiaoningAges 18 years+ - NCT05965258Recruiting
Classify mitral regurgitation using heart scans
This study uses heart imaging to better understand different types of mitral valve leak (mitral regurgitation) and how it relates to heart pumping function. Results may help doctors match people to the most appropriate care based on scan “patterns.”
Cleveland, OhioAges 18 years+ - NCT06038838Recruiting
Tioga TMVR system feasibility study for mitral regurgitation
This trial tests a new device called the Tioga TMVR system to treat moderate to severe mitral regurgitation (leaky heart valve). It is for people who cannot have standard surgery or other less invasive treatments.
São PauloAges 18 years+ - NCT06162780Recruiting
Clip repair for severe mitral valve leak
This trial tests a clip-based procedure (TEER) to fix a severe leak in the mitral valve for people who have symptoms or heart changes but are at low to medium risk for surgery. The goal is to see if this less invasive option works well and is safe.
Guangzhou, GuangdongAges 18 years+ - NCT06633159Recruiting
MitraClip in Patients With Heart Failure
This study looks at how well a clip (MitraClip G4) fixes a leaky heart valve in people with heart failure. If you are scheduled for this procedure, joining may help doctors learn more about the benefits of the clip.
MoscowAges 18 years+ - NCT06648577Recruiting
3D ultrasound heart muscle wave measurements
This study uses 3D ultrasound to measure mechanical waves in the heart muscle of people with different severities of mitral regurgitation (a leaky heart valve). It aims to better understand how the heart adapts to the leak, which could help guide treatment decisions.
Paris, ParisAges 18 years+ - NCT06726109Recruiting
FOCUS study on acute heart failure
This trial is studying patients admitted to the hospital for acute heart failure. It will collect information to better understand and treat people with low heart pumping strength (ejection fraction less than 40%) and fluid retention.
Genk, BelgiumAges Any age - NCT06770062Recruiting
How the heart changes after mitral valve repair surgery
This study at Mayo Clinic uses MRI and other tests to see how the heart's main pumping chamber changes shape after robot-assisted mitral valve repair surgery for severe mitral regurgitation. It may help doctors better understand how patients recover.
Rochester, MinnesotaAges 18 years+ - NCT06901466RecruitingPhase 4
Blood thinner study after heart valve repair
This study tests different ways to use blood thinners after a minimally invasive heart valve repair procedure. It may help patients who need long-term blood thinning to prevent clots or stroke.
Beijing, Beijing MunicipalityAges Any age - NCT06951672Recruiting
Testing a new mitral valve repair device
This trial tests a new device called AMEND™ that is placed through a vein in the leg to repair a leaky mitral valve without open-heart surgery. It is for people with significant mitral regurgitation who are at high risk for surgery.
Phoenix, ArizonaAges 21 years+ - NCT07007143RecruitingPhase 4
Blood thinner study after heart valve repair
This trial tests different blood-thinning medicines after a mitral valve repair procedure (TEER) in people who do not need long-term blood thinners. It aims to find the safest and most effective strategy to prevent blood clots.
Beijing, Beijing MunicipalityAges Any age - NCT07086534Recruiting
GeminiOne Clip for Severe Mitral Regurgitation
This trial tests a new device called GeminiOne that clips together part of your leaky mitral valve to reduce backward blood flow. It is for people with severe mitral regurgitation who are not candidates for open-heart surgery.
Thousand Oaks, CaliforniaAges 18 years+ - NCT07108907Recruiting
Registry study of M-TEER heart valve repair
This registry study follows people who are getting a minimally invasive heart valve repair called M-TEER. It helps doctors learn more about how well the procedure works and how patients recover.
Amsterdam, North HollandAges Any age - NCT02033811Recruiting
MitraClip registry for severe leaky mitral valve
This registry study follows people who have a severely leaky mitral heart valve and receive MitraClip, a procedure that repairs the valve through the skin. It helps doctors learn how well this treatment works over time for different patients.
DüsseldorfAges 18 years+ - NCT06241430Recruiting
CardioClip study: testing a new valve repair for leaky heart valve
This study tests a new clip procedure (CardioClip) to repair a leaky mitral valve in people with heart failure. It aims to see if the clip can improve symptoms and heart function.
New York, New YorkAges 18–90 - NCT07096219Enrolling by invitation
Catheter Ablation for Leaky Mitral Valve in Persistent Atrial Fibrillation
This trial tests if catheter ablation—a procedure to fix heart rhythm—can help people with a leaky mitral valve that is caused by atrial fibrillation (functional mitral regurgitation). If you have persistent atrial fibrillation and moderate leaky valve, you may benefit from this treatment.
Guangzhou, GuangdongAges 18–75 - NCT05305612Enrolling by invitationPhase 4
Blood thinner timing during heart procedures to protect against clots
This study compares the best way to give blood thinners around certain heart procedures (TEER or left atrial appendage closure). It aims to lower the risk of dangerous clots and bleeding during and after the procedure.
GdanskAges 18 years+
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Common questions
- Are there clinical trials for mitral regurgitation?
- Yes. Clin2 currently lists 98 recruiting mitral regurgitation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mitral regurgitation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mitral regurgitation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.