Clinical trials
Mitral Valve Stenosis clinical trials
Below are recruiting mitral valve stenosis clinical trials, each written for real people, not researchers. We’re tracking 86 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05511792Recruiting
Smaller valve size approach versus standard valve size in TAVR
This trial compares a “smaller valve sizing” approach versus the usual sizing method during TAVR (a catheter-based valve replacement) for people with bicuspid aortic stenosis. The study aims to see which method improves safety and outcomes for the right valve fit.
Fuzhou, FujianAges 60 years+ - NCT05308888RecruitingPhase 2
PET scan study of heart inflammation after aortic valve replacement
This Phase 2 trial uses a PET scan to study how local inflammation inside the heart affects the heart’s electrical wiring after a minimally invasive aortic valve procedure. The results may help doctors better predict or prevent rhythm and conduction problems after treatment.
BrestAges 18 years+ - NCT05386173Recruiting
Tests fetal aortic valve balloon surgery for severe narrowing
This trial studies whether doing a procedure before birth to open a baby’s aortic valve improves outcomes. It compares this approach in a specific group of pregnancies with severe heart flow problems seen on ultrasound.
San Francisco, CaliforniaAges 5 months–7 months - NCT07662655RecruitingEarly Phase 1
PADN for pulmonary hypertension after mitral valve repair
This study tests a new procedure called pulmonary artery denervation (PADN) to lower high blood pressure in the lungs that persists after a mitral valve repair. It aims to see if this extra treatment improves symptoms and outcomes for people with this condition.
Xiamen, FujianAges 18–80 - NCT04634240Recruiting
Staged heart bypass plus TAVR versus TAVR alone
This study compares doing a staged coronary bypass (revascularization) along with a valve procedure (TAVR) versus doing TAVR and medical treatment alone. It aims to see which approach better helps people with both aortic valve narrowing and coronary artery disease.
Huntsville, AlabamaAges Any age - NCT04029844Recruiting
Transcatheter valve replacement for older adults with severe aortic stenosis
This study tests a new “through-a-vein” heart valve procedure for people age 75+ with severe aortic valve narrowing that causes symptoms. It aims to see if the new valve can be safely implanted and improve outcomes in higher-surgery-risk patients.
LilleAges 75 years+ - NCT06964035Enrolling by invitation
How original valve problem affects new valve's long-term health
This study looks at how the original problem with your aortic valve (narrowing, leaking, or both) might affect how long the replacement valve stays healthy. If you had both your aortic and mitral valves replaced, doctors want to track how well the new valve works over time.
Maastricht, MaastrichtAges 18 years+ - NCT07042529Recruiting
Optimizing valve placement during TAVI
This trial is testing a better way to position a new heart valve during a TAVI procedure. The goal is to help the valve work as well as possible for people with severe aortic stenosis.
AalstAges 18 years+ - NCT05172960Recruiting
Study of a new heart valve for severe aortic stenosis
This trial tests a new version of a heart valve (SAPIEN X4) placed without open-heart surgery. It's for people with severe aortic stenosis who have symptoms like shortness of breath or chest pain.
La Jolla, CaliforniaAges Any age - NCT04414878Recruiting
Transcatheter aortic valve replacement for older, high-risk patients
This trial tests a new heart valve replacement done through a catheter (not open-heart surgery) in older adults with severe aortic valve narrowing. It’s mainly for people who are high-risk or not good candidates for standard surgery, to see if the new valve improves outcomes.
Beijing, Beijing MunicipalityAges 70 years+ - NCT07278310Recruiting
Siegel Valve for Severe Aortic Stenosis (TAVR)
This study tests a new replacement valve called the Siegel, placed through a catheter in your leg (TAVR), for people with severe aortic stenosis. It aims to see if it is safe and effective for patients at low, intermediate, or high surgical risk.
Atlanta, GeorgiaAges 18 years+ - NCT05040074Recruiting
Transcatheter repair for leaking mitral valve in high-risk patients
This trial studies a minimally invasive device meant to fix a badly leaking mitral valve (mitral regurgitation) without open-heart surgery. It may be an option if you’re considered too high-risk for standard surgery and your heart anatomy fits the device.
Shenyang, LiaoningAges 18 years+ - NCT07086534Recruiting
GeminiOne Clip for Severe Mitral Regurgitation
This trial tests a new device called GeminiOne that clips together part of your leaky mitral valve to reduce backward blood flow. It is for people with severe mitral regurgitation who are not candidates for open-heart surgery.
Thousand Oaks, CaliforniaAges 18 years+ - NCT07596394Recruiting
Registry of Catheter-Based Aortic Valve Replacements
This registry collects information about patients who receive a new valve inserted through a catheter (a thin tube) rather than open surgery. It tracks how well the procedure works and any side effects to help doctors understand the long-term safety and effectiveness of this less invasive approach.
Pavia, PaviaAges 18 years+
Hear when a new Mitral Valve Stenosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for mitral valve stenosis?
- Yes. Clin2 currently lists 86 recruiting mitral valve stenosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mitral valve stenosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mitral valve stenosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.