Clinical trials
Neoadjuvant clinical trials
Below are recruiting neoadjuvant clinical trials, each written for real people, not researchers. We’re tracking 903 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06487429RecruitingPhase 2
Short radiation followed by combo therapy for HER2+ stomach cancer
This trial tests a new approach for stomach cancer that has spread to nearby tissues but not to other organs. You would get a short course of radiation, followed by a combination of targeted therapy (Disitamab Vedotin), chemotherapy (S-1), and immunotherapy (Sintilimab) before surgery to shrink the tumor and improve outcomes.
Wuhan, HubeiAges 18–75 - NCT06492408RecruitingPhase 2
Immunotherapy before surgery for liver cancer
This trial tests giving two immunotherapy drugs directly into the tumor before surgery for liver cancer. It aims to see if this approach can shrink the tumor and improve outcomes for patients who are candidates for surgery.
Guanzhou, GuangdongAges 18–75 - NCT06492421RecruitingPhase 2
Immunotherapy before surgery for lung cancer
This trial tests whether giving two immunotherapy drugs directly into the tumor before surgery can shrink non-small cell lung cancer and improve outcomes. It is for people with early-stage (IIIA) lung cancer who are candidates for surgery.
Guanzhou, GuangdongAges 18–75 - NCT06500208RecruitingPhase 2
Adebrelimab plus chemo before surgery for high-risk breast cancer
This trial tests a combination of an immunotherapy drug (adebrelimab) plus chemotherapy before surgery for people with high-risk, hormone receptor-positive, HER2-negative breast cancer. The goal is to see if this approach can shrink tumors more effectively than chemotherapy alone.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT06504147RecruitingPhase 2
Radspherin for ovarian cancer with peritoneal spread
This trial tests a radioactive treatment called Radspherin given during surgery for advanced ovarian cancer that has spread to the lining of the abdomen. It is for people whose tumors are HR proficient (a specific genetic type) and who have already had chemotherapy before surgery.
Tampa, FloridaAges 18 years+ - NCT06506838RecruitingPhase 4
Anlotinib, chemo, and radiation before sarcoma surgery
This trial tests combining anlotinib (a targeted therapy), doxorubicin (chemotherapy), and radiation given before surgery to shrink high-grade soft tissue sarcomas. The goal is to make the tumor easier to remove and improve outcomes.
Guangzhou, GuangdongAges 18–75 - NCT06516445RecruitingPhase 2
Short radiation plus targeted drugs before surgery for rectal cancer
This trial tests a new combination of treatments before surgery for locally advanced rectal cancer. You would receive short-course radiation, then an immunotherapy drug (camrelizumab) plus a PARP inhibitor (fluzoparib) and chemotherapy, to shrink the tumor and make surgery more successful.
Wuhan, HubeiAges 18–75 - NCT06521541Recruiting
Prehabilitation program for stomach cancer surgery patients
This study tests a program of nutrition, exercise, and emotional support before and during chemotherapy and stomach cancer surgery. It aims to help patients recover faster and have fewer complications.
Qingdao, ShandongAges 18 years+ - NCT06530316Recruiting
RET inhibitor before surgery for advanced thyroid cancer with RET changes
This trial tests a targeted drug (a RET inhibitor) taken before surgery to help shrink thyroid cancer that has a specific genetic change (RET alteration). It may make surgery easier or more successful.
ShanghaiAges 14–80 - NCT06534489Recruiting
Surgery for lung cancer after chemo or targeted therapy
This trial tests whether combining chemo or targeted therapy before surgery can help people with non-small cell lung cancer that may require removing a whole lung. We want to see if this approach makes the surgery safer and more effective.
ShanghaiAges 18–75 - NCT06537154RecruitingPhase 2/Phase 3
Neoadjuvant therapy for bladder cancer with active surveillance
This trial tests whether people with muscle-invasive bladder cancer can safely avoid immediate surgery or radiation after a short course of chemotherapy. Instead, they would be closely monitored and only treated if the cancer comes back.
Vancouver, British ColumbiaAges 19 years+ - NCT06542588RecruitingPhase 2
Short radiation plus chemo and immunotherapy for rectal cancer
This trial tests a combination of short-course radiation, chemotherapy, and two types of immunotherapy (HLX07 and Serplulimab) before surgery for advanced rectal cancer. It aims to see if this approach helps shrink tumors and improve outcomes.
Wuhan, HubeiAges 18–75 - NCT06548789RecruitingPhase 2
Immunotherapy plus prebiotic foods for melanoma before surgery
This study tests if eating certain prebiotic foods while receiving immunotherapy before melanoma surgery can boost your immune system and improve treatment response. Participants eat study-provided foods and receive standard immunotherapy (ipilimumab with or without nivolumab, or nivolumab with or without relatlimab).
Houston, TexasAges 18 years+ - NCT06558682Recruiting
Pre-surgery treatment for HER2-positive cervical cancer
This trial tests a treatment given before surgery for cervical cancer that is both squamous cell type and HER2-positive. It aims to see if this approach works better for patients with these specific markers.
Jinan, ShandongAges 18–70 - NCT06559371Recruiting
PET scan to check lymph nodes after breast cancer treatment
This study uses a special PET scan (68Ga FAPI) to check if lymph nodes under the arm still have cancer after you finish pre-surgery treatment. It helps doctors see how well the treatment worked before you have surgery.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06559696RecruitingPhase 3
Radiation to internal mammary lymph nodes for high-risk breast cancer after chemo
This trial tests whether giving radiation to the internal mammary lymph nodes (the lymph nodes behind your breastbone) can help women with high-risk breast cancer after they have had chemotherapy before surgery. It is for people whose cancer has spread to nearby lymph nodes despite chemotherapy.
Fuzhou, FujianAges 18–75 - NCT06563869RecruitingPhase 3
Sintilimab with chemo and growth factor before esophageal cancer surgery
This trial tests whether giving the immunotherapy drug sintilimab together with standard chemotherapy and a growth factor injection before surgery can help people with a certain type of esophageal cancer (squamous cell carcinoma) that is still removable. The goal is to improve treatment outcomes before the operation.
Nanjing, JiangsuAges 18–75 - NCT06563999RecruitingPhase 2
Study of new drugs for stage III lung cancer with rare gene changes
This trial tests whether giving treatment before surgery (neoadjuvant therapy) can help people with stage III lung cancer that has certain rare gene changes. The goal is to see if this approach can shrink the tumor enough to allow surgery.
Guangzhou, GuangdongAges 18–75 - NCT06567782RecruitingPhase 2
Immunotherapy plus chemotherapy vs. chemotherapy alone for stage 3 colon cancer
This trial tests whether adding the immunotherapy drug dostarlimab to standard chemotherapy (CAPEOX) is more effective than chemotherapy alone for people with a specific type of colon cancer (MMRp/MSS) that has not spread. It is given before surgery to shrink the tumor.
AalstAges 18 years+ - NCT06569368RecruitingPhase 2
Metronidazole with rectal cancer treatment
This trial tests adding the antibiotic metronidazole to standard pre-surgery therapy for locally advanced rectal cancer. The goal is to see if changing the bacteria in your gut can make the cancer treatment work better.
Houston, TexasAges 18 years+ - NCT06571396Recruiting
Surgery risks after immunotherapy for liver cancer
This study looks at the risks of surgery in people with liver cancer who received immunotherapy before or instead of surgery. It aims to understand how safe and effective this approach is.
Jinan, ShandongAges 18 years+ - NCT06575257RecruitingPhase 2
Darolutamide and Hormone Therapy Before Prostate Surgery
This trial tests giving a new hormone-blocking drug (darolutamide) plus standard hormone therapy before surgery for men with high-risk prostate cancer that has not spread. The goal is to see if this approach improves outcomes.
Xi’an, ShanxiAges 18–75 - NCT06576921RecruitingPhase 2
Study of serplulimab with chemo before surgery for stomach cancer
This trial tests if adding serplulimab to standard chemotherapy before surgery can help shrink locally advanced stomach or gastroesophageal junction cancer. It aims to improve treatment outcomes for patients who are candidates for surgery.
Shijiazhuang, Heibei ProvinceAges 18–75 - NCT06576973RecruitingPhase 2
Adalimumab combo therapy for esophageal cancer before surgery
This trial tests a combination of an immunotherapy drug (adalimumab), chemotherapy, and a targeted therapy pill (apatinib) before surgery for esophageal cancer that can be removed. The goal is to see if this mix helps shrink the tumor and improve outcomes.
Hangzhou, ChinaAges 18–75
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Common questions
- Are there clinical trials for neoadjuvant?
- Yes. Clin2 currently lists 903 recruiting neoadjuvant studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a neoadjuvant trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a neoadjuvant trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.