Clinical trials
Non-small Lung Cancer clinical trials
Below are recruiting non-small lung cancer clinical trials, each written for real people, not researchers. We’re tracking 1,091 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04210492RecruitingPhase 1/Phase 2
Radiation for centrally located lung cancer, tested in 3 treatments
This trial tests a safer, lower-dose radiation approach given in three sessions for centrally located lung tumors. It aims to deliver effective treatment while protecting nearby sensitive structures like the heart, esophagus, and major airways.
Greenwich, ConnecticutAges 18 years+ - NCT04165798Recruiting
Pembrolizumab with or without chemotherapy for stage IV lung cancer
This trial tests whether pembrolizumab alone, or pembrolizumab plus chemotherapy, can treat stage IV non-small cell lung cancer. It may help shrink tumors and improve outcomes by boosting the immune system, with or without added chemotherapy.
Gilbert, ArizonaAges 18 years+ - NCT04165070RecruitingPhase 1/Phase 2
Stage IV lung cancer trial using pembrolizumab with or without chemotherapy
This Phase 1/2 study tests pembrolizumab (an immune-based cancer treatment) either alone or with chemotherapy in people newly diagnosed with stage IV non-small cell lung cancer (NSCLC). It looks at how well the treatments work and whether they are safe, especially in people who haven’t had treatment yet for metastatic disease.
Gilbert, ArizonaAges 18 years+ - NCT04198766RecruitingPhase 1/Phase 2
New OX40 immunotherapy for advanced solid tumors
This trial tests a new immunotherapy drug (INBRX-106) alone or with Keytruda (pembrolizumab) for adults with advanced solid tumors that have not responded to standard treatments. The goal is to see if the drug can help the immune system fight cancer.
Duarte, CaliforniaAges 18 years+ - NCT03917043RecruitingPhase 1
Testing a new targeted drug for ALK or ROS1 lung cancers
This Phase 1 trial tests APG-2449, a new drug, in people with advanced solid tumors—especially certain lung cancers that have ALK or ROS1 gene fusions. Because it’s an early safety-and-dose study, it may help learn how well the drug works and what doses are safe.
Beijing, Beijing MunicipalityAges 18 years+ - NCT03953144RecruitingPhase 1/Phase 2
3D lung surgery planning with a dye to find tumors
This trial tests a new way to plan and guide lung cancer surgery using a special dye that shows the tumor area during the operation. It may help surgeons remove the cancer more accurately while targeting only a small section of lung for certain early-stage patients.
Hamilton, OntarioAges 18 years+ - NCT03958565Recruiting
Study how targeted drugs affect bone tumors in lung cancer
This trial studies how tyrosine kinase inhibitor (TKI) medicines work against non-small cell lung cancer that has spread to the bone. It’s for people with specific “actionable” gene changes, to see how well these treatments reduce or change bone metastases.
Aurora, ColoradoAges 18–100 - NCT03948100Recruiting
Yoga coaching for lung or esophageal cancer during radiation
This study tests whether a guided yoga program helps people with lung or esophageal cancer improve strength, daily functioning, and quality of life while they receive radiation therapy. It also involves a family caregiver, to support the patient during treatment.
Houston, TexasAges 18 years+ - NCT03851445RecruitingPhase 2/Phase 3
Lung cancer screening trial using tumor and blood test results
This trial helps sort people with previously treated lung cancer into the best next treatment options by using new tumor tissue (and sometimes blood) test results. It may help you get matched to therapies based on features like PD-L1 and other biomarkers.
Birmingham, AlabamaAges 18 years+ - NCT03819296RecruitingPhase 1
Fecal transplant to treat cancer immunotherapy bowel side effects
This early-phase study tests whether changing your gut bacteria with a fecal transplant can improve diarrhea or colitis caused by cancer immunotherapy. It may help people whose symptoms have not fully settled with standard treatments like steroids and other immune-blocking medicines.
Houston, TexasAges 18 years+ - NCT03774758Recruiting
Blood tests to estimate lung cancer risk over 3 years
This study looks for blood “biomarkers” (measurable signs in blood) that may help predict who is at higher or lower risk related to lung cancer. You would have blood samples taken and then be followed with visits for up to 3 years.
San Francisco, CaliforniaAges 40 years+ - NCT03808337RecruitingPhase 2
SBRT radiation plus standard treatment for spread cancer
This trial looks at adding a focused radiation treatment called SBRT to standard care for cancers that have spread to a limited number of spots. It aims to control those spread-out tumors while still using the usual cancer treatment plan.
San Carlos, CaliforniaAges 18 years+ - NCT03706027Recruiting
Compare two radiation timing plans for early lung cancer
This trial tests whether two different schedules (timing) of radiation have different side effects in people with early-stage non-small cell lung cancer. It may help reduce or better understand treatment toxicity while still treating the cancer.
Rochester, New YorkAges 18 years+ - NCT03412877RecruitingPhase 2
Personalized immune-cell therapy for advanced metastatic cancers
This trial tests a personalized cell therapy made from your own immune cells, changed to recognize “neoantigens” on cancer cells. It’s designed for people with metastatic (advanced spread) solid cancers or certain other cancers who have tried standard treatments but cancer is still growing.
Bethesda, MarylandAges 18–72 - NCT03191149RecruitingPhase 2
Osimertinib for lung cancer with an EGFR exon 20 change
This Phase 2 study tests osimertinib (a targeted lung cancer pill) in people with advanced non-small cell lung cancer (NSCLC) whose tumors have an EGFR exon 20 insertion. It aims to see how well osimertinib works for this specific EGFR mutation and how safe it is.
Anchorage, AlaskaAges 18 years+ - NCT03042221Recruiting
Early re-biopsy to find why tumors survive targeted drugs
This study takes a small tumor sample early after starting targeted treatment (or uses blood if a biopsy isn’t possible) to look for clues—called biomarkers—about why some tumor cells survive. The results may help improve how future patients’ treatments are chosen for certain lung cancer gene mutations.
Aurora, ColoradoAges 18–85 - NCT03199651Recruiting
Study for people with stage IV lung cancer
This study focuses on improving outcomes for people with stage IV non-small cell lung cancer by gathering health, treatment, and lifestyle information. It may help researchers understand what supports survival and care planning, especially for people who are current smokers or recent quitters.
Columbus, OhioAges 18 years+ - NCT02682667Recruiting
Providing blood samples for cancer immunotherapy research
This study collects and stores blood/tissue samples (called biospecimens) to support immunotherapy research at the cancer center. If you may qualify, your samples help researchers test new immune-based cancer treatments.
Bethesda, MarylandAges 18–120 - NCT02978521Recruiting
Pulmonary rehab program for advanced lung cancer
This trial studies whether a structured breathing and activity program (pulmonary rehabilitation) can help people with advanced non-small-cell lung cancer. It may help improve breathing and daily function alongside standard cancer treatment.
Mexico City, Mexico CityAges 18–70 - NCT02838836Recruiting
Checking for cancer DNA and tumor cells in bodily samples
This study looks for cancer-related material in blood, urine, and sometimes bone marrow. It may help researchers understand how to detect cancer activity and track it over time using less invasive tests.
Columbia, MissouriAges 18 years+ - NCT02622581Recruiting
Lung cancer research registry for treatment and outcomes
This study collects information from people with lung cancer to understand how different treatments work and what outcomes they have. It includes patients with non-small cell lung cancer (NSCLC) or small cell lung cancer (SCLC) at various stages.
OldenburgAges 18 years+ - NCT02468024RecruitingPhase 3
Surgery or focused radiation for early lung cancer
This study compares two treatments—removing only part of the lung (sublobar resection) versus a focused radiation approach (stereotactic ablative radiotherapy)—for early-stage non-small cell lung cancer. It aims to see which option works better with fewer problems for the right patients.
La Jolla, CaliforniaAges 18 years+ - NCT02570815RecruitingPhase 1
Fluorescent-guided robotic lung surgery for early lung cancer
This early-stage trial tests a robotic lung surgery that uses a special dye with near-infrared light to help the surgeon remove only the tumor area. If you have a small, early lung cancer, this approach may help improve accuracy while limiting how much lung is removed.
Hamilton, OntarioAges 18 years+ - NCT02133196RecruitingPhase 2
T-cell treatment for lung cancer that has spread
This Phase 2 study tests a T-cell–based immunotherapy for people with metastatic non-small cell lung cancer that has grown despite prior treatment. It may help your immune system recognize and fight your cancer using cells made from your tumor.
Bethesda, MarylandAges 18–72
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Common questions
- Are there clinical trials for non-small lung cancer?
- Yes. Clin2 currently lists 1,091 recruiting non-small lung cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a non-small lung cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a non-small lung cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Non Small Cell Lung Cancer
- Non-squamous Non-small Cell Lung Cancer
- Lung Cancer Non-Small Cell Cancer (NSCLC)
- Metastatic Non-squamous Non Small Cell Lung Cancer
- Advanced Non-squamous Non-small-cell Lung Cancer
- NSCLC (Advanced Non-small Cell Lung Cancer)
- Non Small Cell Lung Cancer Metastatic
- Lung Cancer, Non-Small Cell
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.