Clinical trials · California
Obesity clinical trials in California
We’re tracking 118 recruiting obesity studies with a site in California — including Phase 1, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT07654374RecruitingPhase 3
Study of a new pill for weight loss and diabetes
This study tests a new daily pill (aleniglipron) to help adults with excess weight and type 2 diabetes lose weight and improve blood sugar control. It may be a good fit if you have a BMI of 27 or higher and your diabetes is managed with A1c between 6.5% and 10%.
Escondido, CaliforniaAges 18–79 - NCT07654361RecruitingPhase 3
A new pill for weight loss in obesity and overweight
This study tests an investigational pill called aleniglipron to see if it helps people with obesity or overweight who also have a weight-related health problem (like high blood pressure) lose weight safely. It is a Phase 3 trial, meaning it is in the final stages before seeking approval.
Escondido, CaliforniaAges 18–79 - NCT05165706Recruiting
Study of how obesity affects insulin resistance over time
This study follows adults over time to understand how weight and body chemistry relate to insulin resistance. It may help researchers learn why insulin resistance happens and what could prevent or improve it.
Stanford, CaliforniaAges 35–65 - NCT05912621RecruitingPhase 2
Tirzepatide for fat-related body dysfunction in overweight adults
This Phase 2 study tests whether tirzepatide can improve how your body handles fat (especially in people with overweight or obesity) and reduce fat-related “lipotoxicity.” It may help with body fat function and related health markers, but you must meet specific health and medication rules.
Palo Alto, CaliforniaAges 18–70 - NCT07594093RecruitingPhase 1
A study of REGN20934 for adults with overweight or obesity
This trial tests a new medication, REGN20934, to see how safe it is and how it works in the body for adults who are overweight or have obesity. It may help if you are looking for new treatment options.
Glendale, CaliforniaAges 18–65 - NCT07589608RecruitingPhase 2
Weight Loss Study With Two New Injectable Medications
This study tests two new injectable drugs (macupatide and eloralintide) alone or together to help adults with obesity or excess weight lose weight. The goal is to see if these medications are safe and effective for weight management.
Greenbrae, CaliforniaAges 18–75 - NCT07575399RecruitingPhase 3
Switching to a New Weight-Loss Medication From Current GLP-1
This trial tests whether switching from your current GLP-1 medication (like Ozempic or Wegovy) to a new drug called maridebart cafraglutide works as well or better for weight management. You must have already lost at least 10% of your body weight on your current GLP-1 and be doing well with it.
Palm Springs, CaliforniaAges 18–99 - NCT07567001RecruitingPhase 3
Testing NNC0487-0111 for Heart Failure and Obesity
This study tests whether a new medication called NNC0487-0111 can help people with heart failure who also have obesity. Researchers will compare it to a placebo (inactive pill) to see if it improves heart function and overall health.
Northridge, CaliforniaAges 18 years+ - NCT07566390RecruitingPhase 1
Testing a new weight-loss medicine in healthy adults
This early-stage study tests a new experimental medicine (NNC0113-5840) to see how it works in people who are overweight or have obesity. Researchers want to understand how the body processes this medicine and whether it's safe before testing it more widely.
Glendale, CaliforniaAges 18–55 - NCT07564414RecruitingPhase 3
Weight Loss Study Comparing Two Doses of CagriSema
This study tests whether a new combination medication called CagriSema (in two different doses) helps people with obesity lose weight. You may qualify if you're 18 or older, have a BMI of 35 or higher, and either don't have type 2 diabetes or have it well-controlled.
Northridge, CaliforniaAges 18 years+ - NCT07511205RecruitingPhase 1
Study of AZD1043 for overweight or obesity
This trial tests a new medicine called AZD1043 in healthy adults who are overweight or have obesity. It aims to see if the medicine is safe and how the body handles it.
Glendale, CaliforniaAges 18–65 - NCT07392190RecruitingPhase 3
Study of eloralintide for people with persistent obesity
This trial tests if adding eloralintide helps people who are still obese or overweight while taking weekly incretin therapy. It aims to support additional weight loss for those who haven't reached their goals.
San Diego, CaliforniaAges 18 years+ - NCT07395687RecruitingPhase 2
Study of UBT251 for people with overweight or obesity
This trial tests different doses of UBT251, a new medicine, to see how well it helps people lose weight. It may be an option if you have overweight or obesity and meet certain age and BMI requirements.
Cypress, CaliforniaAges 18–65 - NCT07369011RecruitingPhase 3
Study of eloralintide for sleep apnea with obesity
This study tests an investigational medication called eloralintide to see if it can improve sleep apnea in people who are overweight or have obesity. You will receive either the study drug or a placebo (inactive shot), and your sleep and weight will be monitored over time.
Long Beach, CaliforniaAges 18 years+ - NCT07353931RecruitingPhase 3
Study of eloralintide for knee osteoarthritis pain in people with overweight or obesity
This trial tests an investigational drug called eloralintide to see if it can reduce knee pain in people with osteoarthritis who also have overweight or obesity. You may be able to join if you have knee osteoarthritis, a BMI of 27 or higher, and have tried to lose weight with diet before.
Fountain Valley, CaliforniaAges 18 years+ - NCT07351058RecruitingPhase 3
Enicepatide for weight loss in people with type 2 diabetes
This trial tests an investigational medication, Enicepatide, to see if it helps people with obesity or overweight and type 2 diabetes lose weight and improve blood sugar control. You will receive weekly injections and regular check-ups.
Irvine, CaliforniaAges 18 years+ - NCT07351045RecruitingPhase 3
Study of enicepatide for weight loss in obesity or overweight
This study tests a new injectable medication called enicepatide for people with obesity or overweight who have not been able to lose weight through diet and exercise alone. It may help you lose weight and improve health conditions linked to excess weight.
Irvine, CaliforniaAges 18 years+ - NCT07321886RecruitingPhase 3
Study of eloralintide for people with obesity or overweight
This trial tests if an investigational drug called eloralintide can help people with obesity or overweight lose weight. It is for people who do not have type 2 diabetes and who have tried but struggled to lose weight on their own.
Escondido, CaliforniaAges 18 years+ - NCT07291232RecruitingPhase 1
Study of an injected drug for adults with obesity
This study tests an injected medication called ABBV-295 for adults with obesity. The goal is to see how safe it is and how the body processes it. You may join if you have a BMI between 30 and 45 and are generally healthy, and you haven't been on other weight loss treatments recently.
Anaheim, CaliforniaAges 18–65 - NCT07282600RecruitingPhase 3
Study of eloralintide for type 2 diabetes and weight
This study tests a new medicine called eloralintide for people with type 2 diabetes who are overweight or have obesity. It aims to see if the drug can help with weight loss and blood sugar control.
Canoga Park, CaliforniaAges 18 years+ - NCT05419726Recruiting
Semaglutide study to see how brown fat responds in weight loss
This trial studies how brown fat (a type of body fat) changes after starting semaglutide for weight loss. You may help researchers understand how this medication affects the body’s energy use, which could improve weight-loss treatments.
Los Angeles, CaliforniaAges 18 years+ - NCT07090005Recruiting
Endoscopic weight loss: comparing EndoZip and Apollo ESG
This study compares two different endoscopic procedures (EndoZip and Apollo ESG) to help obese patients lose weight. Both are done through the mouth without cutting the skin, and the goal is to see which works better and is safer.
Los Angeles, CaliforniaAges 21–65 - NCT07037459RecruitingPhase 3
A study of a new drug for heart failure with obesity
This trial tests a medication called maridebart cafraglutide for people with heart failure (where the heart doesn't pump as well as it should) and obesity. The goal is to see if it can help improve symptoms and outcomes.
Beverly Hills, CaliforniaAges 18–99 - NCT07037433RecruitingPhase 3
Heart protection study for people with heart disease and overweight
This study tests a new weekly injection (maridebart cafraglutide) to see if it helps lower the risk of heart problems in people with heart disease and overweight. It is for adults who have had a heart attack, stroke, or artery blockages and also have a BMI of 27 or higher.
Covina, CaliforniaAges 45–99
Obesity trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting obesity studies listed above.
- Diablo Clinical Research · 5 studies
- Ark Clinical Research · 4 studies
- Desert Oasis Healthcare Medical Group · 4 studies
- Encompass Clinical Research · 4 studies
- Peninsula Research Associates · 4 studies
- Artemis Institute for Clinical Research · 3 studies
- Pacific Clinical Studies · 3 studies
- Southern California Clinical Research · 3 studies
What taking part in a obesity study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Obesity trials in other states
Common questions
- Are there obesity clinical trials in California?
- Yes. We're currently tracking 118 recruiting obesity studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a obesity study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a obesity trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New obesity studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.