Clinical trials · Pennsylvania
Oncology clinical trials in Pennsylvania
We’re tracking 112 recruiting oncology studies with a site in Pennsylvania — including Phase 1, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Pennsylvania
- NCT06377852RecruitingPhase 3
Dosing study for older adults with advanced breast cancer
This trial studies how well different doses of CDK4/6 inhibitors (palbociclib or ribociclib) work in people aged 65 or older with HR+/HER2- metastatic breast cancer. It aims to find the best starting dose to balance effectiveness and side effects.
Philadelphia, PennsylvaniaAges 65 years+ - NCT06418204Recruiting
Cannabis use study for cancer patients in community clinics
This study looks at the benefits and risks of using cannabis or cannabinoids for cancer patients. It aims to help understand how these products affect symptoms and quality of life during chemotherapy or immunotherapy.
York, PennsylvaniaAges 18 years+ - NCT06457503RecruitingPhase 4
Toripalimab plus chemo for advanced nasopharyngeal cancer
This trial tests whether adding the immunotherapy drug toripalimab to standard chemotherapy (cisplatin and gemcitabine) can help people whose nasopharyngeal cancer has come back or spread. It is for those who haven't yet received other treatments for this advanced stage.
Hershey, PennsylvaniaAges 12 years+ - NCT06500455RecruitingPhase 3
Standard vs longer radiation for brain metastases
This trial compares the usual short course of radiation therapy (one session) to a longer course (up to 5 sessions) for people with cancer that has spread to the brain. The goal is to see if the longer course works better and causes fewer side effects.
Allentown, PennsylvaniaAges 18 years+ - NCT06532279RecruitingPhase 2
Testing BMX-001 with chemoradiation for head and neck cancer
This trial tests whether adding BMX-001 (a drug that may protect healthy tissues) to standard chemoradiation can reduce side effects and improve outcomes for people with head and neck cancer. It's a randomized study, so you would have a 50/50 chance of getting BMX-001 or a placebo.
Chambersburg, PennsylvaniaAges 18 years+ - NCT06567743RecruitingPhase 2
Study of a new virus therapy for high-risk bladder cancer
This trial tests a new virus-based medicine, cretostimogene grenadenorepvec, given directly into the bladder for people with high-risk non-muscle-invasive bladder cancer. It may help prevent the cancer from coming back, especially for those who have not had BCG treatment or whose cancer did not respond to BCG.
Hershey, PennsylvaniaAges 18 years+ - NCT06588478RecruitingPhase 2
Study of pirtobrutinib for CLL or SLL
This trial tests a new drug called pirtobrutinib for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). It is for those whose cancer has come back or not responded to treatment, including a prior BTK inhibitor, and also for those who have never been treated but have a specific genetic change (17p deletion).
York, PennsylvaniaAges 18 years+ - NCT06625203Recruiting
Building a large cancer data collection from patients worldwide
This study is building a large collection of cancer data (like medical records, images, and genetic information) from many patients. It aims to learn more about different cancers and may lead to better treatments.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06626919RecruitingPhase 1
A cell therapy trial for generalized myasthenia gravis
This trial tests a new cell therapy called anitocabtagene autoleucel (anito-cel) for people with generalized myasthenia gravis (gMG) that is not well controlled with current treatments. The goal is to see if it can reduce symptoms and improve quality of life.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06655246RecruitingPhase 1
Ziftomenib and imatinib for advanced GIST
This trial tests a new drug, ziftomenib, combined with imatinib for people with advanced or spreading gastrointestinal stromal tumors (GIST) that have a KIT mutation. It may help if your GIST has gotten worse while on imatinib.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06657144RecruitingPhase 1
Study of CHS-114 and toripalimab for advanced solid tumors
This study tests a new drug combo (CHS-114 + toripalimab) for people with advanced solid tumors like stomach, esophageal, or colorectal cancer that have already been treated. It aims to see if adding these drugs can help control the cancer better.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06724237RecruitingPhase 3
High-dose chemo and stem cell transplant for T-cell lymphoma patients in remission
This trial tests whether high-dose chemotherapy followed by a stem cell transplant using your own cells can help people with certain types of peripheral T-cell lymphoma live longer. You would qualify if you have already finished your first round of chemotherapy and are in complete remission.
Chadds Ford, PennsylvaniaAges 18–75 - NCT06731998Recruiting
Improving pain control after cancer surgery
This study compares different methods of managing pain after minimally invasive surgery for abdominal cancers. It aims to find which approach works best to reduce pain and improve recovery.
Pittsburgh, PennsylvaniaAges 18–89 - NCT06872515Recruiting
Exercise before esophageal cancer surgery
This trial tests if doing supervised exercise before esophageal cancer surgery (called prehabilitation) helps people recover better. You would follow a personalized exercise plan for at least 2 weeks before your scheduled surgery.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06877884Recruiting
Cancer care data collection registry
This trial gathers information from your routine cancer care to help researchers learn more about real-world treatments and outcomes. No extra tests or procedures are required.
Paoli, PennsylvaniaAges 18–120 - NCT06892158Recruiting
Massage therapy for sleep in teens with cancer
This trial studies if massage therapy can help teenagers and young adults with cancer sleep better while they are in the hospital. Participants will receive massage sessions and answer questions about their sleep.
Philadelphia, PennsylvaniaAges 12–21 - NCT06958328RecruitingPhase 3
Testing higher dose radiation for locally advanced pancreatic cancer
This trial tests if a higher dose of radiation therapy can help people with locally advanced pancreatic cancer after they've had 4–6 months of chemotherapy. It aims to improve cancer control without significantly increasing side effects.
Chadds Ford, PennsylvaniaAges 18 years+ - NCT06992427RecruitingPhase 3
Gabapentin to prevent opioid use for mouth pain during cancer treatment
This trial tests if taking gabapentin during chemoradiation for head and neck cancer can reduce the need for strong painkillers like opioids. It may help manage mouth pain caused by treatment.
Dickson City, PennsylvaniaAges 18 years+ - NCT07097142RecruitingPhase 3
Shorter radiation for bladder cancer with chemo
This trial tests if a shorter course of radiation therapy works as well as the usual longer course for people with bladder cancer who are also receiving standard chemotherapy. The goal is to see if shorter treatment can reduce side effects while still being effective.
Chadds Ford, PennsylvaniaAges 18 years+ - NCT07166406RecruitingPhase 3
Immunotherapy with or without targeted radiation for advanced liver cancer
This trial tests whether adding a precise, targeted form of radiation (called SBRT) to standard immunotherapy (atezolizumab and bevacizumab) can help people with advanced liver cancer that has spread to the blood vessels or outside the liver. You may be asked to participate in one of two treatment groups to see which approach works better.
Chadds Ford, PennsylvaniaAges 18 years+ - NCT03150693RecruitingPhase 3
New treatment for young adults with CD22-positive ALL
This Phase 3 trial tests adding inotuzumab ozogamicin to standard chemotherapy for newly diagnosed CD22-positive B-cell acute lymphoblastic leukemia (ALL). It may help more patients achieve remission and reduce the risk of the leukemia coming back, while also checking safety and tolerability.
Allentown, PennsylvaniaAges 18–39 - NCT07000084RecruitingPhase 3
Testing gemcitabine with BCG for returning bladder cancer
This trial tests whether adding a chemotherapy drug called gemcitabine to the usual BCG therapy can help prevent bladder cancer from coming back again. If you have had BCG before and your cancer returned, this study might offer a more effective treatment option.
Danville, PennsylvaniaAges 18 years+ - NCT04242095Recruiting
Studies side effects after cancer immunotherapy
This study collects information and biological samples from people who have had significant side effects after immunotherapy for cancer. It aims to understand why these side effects happen and how to improve care for patients in the future.
Allentown, PennsylvaniaAges Any age - NCT05080673Recruiting
Colonoscopy planning for small, noncancerous colon polyps
This trial tests whether people with 1–2 small, noncancerous colon polyps should get their next colonoscopy after 5 years or after 10 years. It may help reduce unnecessary procedures or find cancers earlier if the shorter interval is safer for you.
Allentown, PennsylvaniaAges 45–70
Where these studies are running in Pennsylvania
Institutions with a site for the recruiting oncology studies listed above.
- Geisinger Medical Center · 8 studies
- Geisinger Wyoming Valley/Henry Cancer Center · 8 studies
- Geisinger Medical Oncology-Lewisburg · 6 studies
- Christiana Care Health System-Concord Health Center · 5 studies
- Geisinger Cancer Center Dickson City · 5 studies
- Thomas Jefferson University Hospital · 5 studies
- UPMC Hillman Cancer Center · 5 studies
- Geisinger Cancer Services-Pottsville · 4 studies
What taking part in a oncology study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Oncology trials in other states
Common questions
- Are there oncology clinical trials in Pennsylvania?
- Yes. We're currently tracking 112 recruiting oncology studies with a site in Pennsylvania, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a oncology study in Pennsylvania?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Pennsylvania to take part?
- Not necessarily. These studies have a site in Pennsylvania, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a oncology trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New oncology studies open in Pennsylvania regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.