Clinical trials
Opioid clinical trials
Below are recruiting opioid clinical trials, each written for real people, not researchers. We’re tracking 443 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06856733Recruiting
Better opioid management for long-term non-cancer pain
This study tests a new way to help people who have been taking opioids for chronic pain (not caused by cancer) for at least 90 days. The goal is to improve treatment and reduce risks, such as developing tolerance or side effects, while still managing pain effectively.
Strängnäs, SörmlandAges 18–70 - NCT06870110Recruiting
Brain training for opioid use disorder
This trial tests a brain-training program for people with opioid use disorder. It uses an EEG headset to measure brain activity while you do computer exercises, and aims to see if this training can help recovery.
Minneapolis, MinnesotaAges 18–65 - NCT06877858RecruitingPhase 1
MethaLoad dose-finding study for opioid use disorder
This study tests a new way to start methadone treatment (called 'MethaLoad') for people with opioid use disorder who have used fentanyl. If you qualify, you will receive methadone to help manage withdrawal and reduce cravings, and the doctors will closely monitor your safety and response.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06909851Recruiting
Comparing nerve blocks for pain after knee arthroscopy
This study compares two different types of nerve blocks to see which provides better pain relief after arthroscopic knee surgery. You will receive one of the blocks after your surgery, and your pain levels will be tracked.
IstanbulAges 18–72 - NCT06961058Recruiting
Telehealth vs. in-person follow-up for opioid addiction treatment
This study compares follow-up care after an emergency department visit for opioid addiction: either through telehealth (video visits) or in-person appointments. The goal is to see which method helps people stay in treatment after they leave the ED.
El Centro, CaliforniaAges 18 years+ - NCT06963476Recruiting
Magnetic brain stimulation for substance use
This study uses a gentle magnetic stimulation (rTMS) to help people who are already in treatment for alcohol or opioid addiction. The goal is to see if adding rTMS can reduce cravings and improve recovery.
Hartford, ConnecticutAges 18–60 - NCT06967259RecruitingPhase 1
Testing ENA-001 for Opioid-Related Breathing Problems
This study tests a new medicine (ENA-001) that helps restore normal breathing when it has slowed down too much due to opioid painkillers. Healthy volunteers will receive the drug to see how safe it is and how the body handles it.
Miami, FloridaAges 18–55 - NCT06992427RecruitingPhase 3
Gabapentin to prevent opioid use for mouth pain during cancer treatment
This trial tests if taking gabapentin during chemoradiation for head and neck cancer can reduce the need for strong painkillers like opioids. It may help manage mouth pain caused by treatment.
Gilbert, ArizonaAges 18 years+ - NCT07006675RecruitingPhase 3
NSAIDs for Tibia Fracture Pain and Healing Study
This study tests whether NSAID pain relievers (like ibuprofen) affect bone healing after a broken tibia and if they can help reduce the need for stronger painkillers. If you qualify, you could help doctors learn the safest way to manage pain after this common injury.
Indianapolis, IndianaAges 18–80 - NCT07010978Recruiting
Testing recovery community centers for people on medication for opioid use disorder
This study tests whether recovery community centers (RCCs) help people who are taking medication for opioid use disorder (MOUD) stay in recovery. If you are on MOUD and live near a center that serves a Black community, you may be able to join.
Boston, MassachusettsAges 18 years+ - NCT07024498Recruiting
Buprenorphine follow-up after emergency care
This study helps coordinate ongoing care for people who start buprenorphine, a medication for opioid use disorder, while in the emergency department. It aims to connect you with continued treatment to support your recovery.
El Centro, CaliforniaAges 14 years+ - NCT07032987Recruiting
Improving sedation with a new care plan for ICU patients
This trial tests a new sedation protocol for adults in intensive care who need strong pain relief or sedation medicines. It aims to make sedation safer and more comfortable, and includes people on ECMO (a heart-lung machine) or a ventilator (breathing machine) for severe breathing problems.
London, LondonAges 18–100 - NCT07085377Recruiting
Nurse-led methadone program for opioid use disorder
This trial tests a system where nurses can adjust your methadone dose without a doctor's order. It's for people starting methadone treatment for opioid use disorder and willing to be followed at a CSAPA center for 3 months.
BayonneAges 18 years+ - NCT07160075RecruitingPhase 4
HIV prevention with PrEP for people on opioid therapy
This trial tests if daily PrEP medication can help prevent HIV in people receiving opioid replacement therapy. You must be HIV-negative and regularly attend your opioid treatment program to join.
Calgary, AlbertaAges 16 years+ - NCT07166991RecruitingPhase 3
Anesthesia study for organ donation after brain death
This trial compares different anesthesia strategies used during organ donation surgery after brain death to see which one helps preserve organs better for transplant. It is for brain-dead adult patients in the ICU whose families agree to organ donation and research participation.
GrenobleAges 18 years+ - NCT07202039Recruiting
E-Cigarettes for Smokers on Buprenorphine
This study tests whether switching to electronic cigarettes can help reduce harm for people with opioid use disorder who are on buprenorphine and smoke daily. The goal is to see if e-cigarettes are a safer option than continuing to smoke regular cigarettes.
Greenville, South CarolinaAges 21 years+ - NCT07211828Recruiting
Brain activity and pain signals during anesthesia study
This study looks at how opioids and sedatives affect brain activity and pain signals in patients getting anesthesia for an ERCP procedure.
MiaoliAges 18 years+ - NCT07214389Recruiting
Measuring outcomes for opioid treatment program quality
This trial is testing ways to improve quality at opioid treatment programs (OTPs). It may help if you receive care at a BayMark OTP.
Research Triangle Park, North CarolinaAges 18 years+ - NCT07222072RecruitingPhase 4
Methadone to reduce opioid use after spine surgery
This study tests whether giving methadone during and after major spine surgery can help reduce the need for other opioid pain medicines later. It is for adults having multilevel fusion in the lower or mid-back.
Cleveland, OhioAges 18–72 - NCT07226076RecruitingPhase 3
Methadone for knee replacement pain and less opioids
This trial tests if adding methadone during knee replacement surgery can better control pain after the operation and reduce the need for opioid painkillers. It may help you recover with less discomfort and fewer side effects from strong pain medicines.
Charleston, South CarolinaAges 18–75 - NCT07227064RecruitingPhase 3
Methadone for pain relief after hip replacement surgery
This study tests whether a single dose of methadone given during hip replacement surgery can better control pain and reduce the need for other opioid painkillers afterward. It may help you recover with less pain and fewer side effects.
Charleston, South CarolinaAges 18–75 - NCT07228377Recruiting
Virtual reality for cancer pain and opioid use
This study tests if using virtual reality can help manage chronic cancer pain and reduce the amount of opioid pain medicine needed. You would use a VR headset at home and report how you feel.
Washington D.C., District of ColumbiaAges 18 years+ - NCT07262190Recruiting
NavSTAR program for opioid use disorder
This trial tests a program to help people with opioid use disorder start or continue treatment while in the hospital. It aims to connect patients to care after they leave.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07265557Recruiting
Comparing two pain plans after orthopedic surgery
This trial compares two different pain medication plans after major orthopedic surgery. It aims to find which plan helps you recover with less pain and fewer side effects.
Boston, MassachusettsAges 18 years+
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Common questions
- Are there clinical trials for opioid?
- Yes. Clin2 currently lists 443 recruiting opioid studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.