Overweight or Obese Adults clinical trials

How obesity affects movement and daily living in older adults

This study compares how obesity impacts physical abilities and everyday activities in people over 65. Researchers will measure strength, movement, and how well people manage daily tasks to better understand obesity's effects on aging.

How obesity medication affects your eating habits

This study tracks how your eating behavior changes when you take obesity medication. Researchers want to understand what happens to your appetite and food choices before, during, and after treatment to help improve how these medications work.

Genetic and Lifestyle Factors in Weight Management

This study explores how genetics, gut bacteria, and behaviors influence weight gain and obesity. Researchers will examine these factors in adults who are overweight or obese to better understand what drives weight changes.

Weight change study for adults with obesity

This study looks at how weight changes affect health in adults with obesity. You may qualify if you have a high BMI and are willing to try a weight loss program.

Probiotics and Prebiotics for Obesity

This trial tests whether adding probiotics and prebiotics to your diet can help with obesity and related health problems like prediabetes, diabetes, high cholesterol, or high blood pressure.

Testing Psiguavin for weight loss in obesity

This study tests a natural supplement made from guava (called Psiguavin) to see if it helps with weight loss in people who are overweight or have obesity. Participants will take the supplement and be monitored for weight changes and safety.

Redefining Evaluation of Adiposity and Leanness: Broadening Objective Diagnostics for Obesity

Probiotics for Digestion During Weight-Loss Treatment

This study tests whether taking a probiotic (a type of 'good' bacteria) can improve digestion and gut health in people who are starting a GLP-1 RA medicine for weight loss. You would take the probiotic daily and answer questions about your digestive symptoms.

Study of an experimental drug for obesity with or without type 2 diabetes

This study tests an experimental medication called ARO-INHBE in adults with obesity, including those who also have type 2 diabetes. The goal is to see if it helps with weight loss and is safe.

Digital treatment for weight and mood in adults 50+

This study tests a digital program that helps with weight loss and depression at the same time. It is designed for Black, Hispanic, and other adults over 50 who carry extra weight and feel down.

Study of an injected drug for adults with obesity

This study tests an injected medication called ABBV-295 for adults with obesity. The goal is to see how safe it is and how the body processes it. You may join if you have a BMI between 30 and 45 and are generally healthy, and you haven't been on other weight loss treatments recently.

Metformin for depression with obesity: a genetic study

This trial tests if adding metformin to antidepressants helps people who have both depression and obesity. It also looks at genetic factors that might affect treatment response.

Study of eloralintide for people with persistent obesity

This trial tests if adding eloralintide helps people who are still obese or overweight while taking weekly incretin therapy. It aims to support additional weight loss for those who haven't reached their goals.

Remote cooking workshops for adults with obesity

This study tests whether online cooking classes can help adults with obesity improve healthy eating habits. You would attend workshops from home by video and answer questionnaires during the study.

Semaglutide for teens and adults with genetic obesity

This study looks at how semaglutide works in real life for people with obesity caused by a single gene change. If you or your teenager have this type of obesity and are taking or about to start semaglutide, you may be able to join.

Omega-3 for Depression and Obesity

This study tests whether omega-3 fatty acids can improve depression in people with obesity. It looks at how these healthy fats might reduce inflammation and help mood.

Obesity risk factors study in adults

This study looks at how genes and lifestyle affect obesity risk. It includes adults aged 18 to 70 with different weight levels, from overweight to severe obesity.

Testing an adjustable headrest for painless abortion in overweight patients

This study tests whether a special adjustable headrest can help make painless abortion surgery safer and more comfortable for people who are overweight or obese. You may be able to join if you are planning this procedure, have a BMI over 24, and are otherwise healthy enough for anesthesia.

Best filling volume for stomach balloon in weight loss

This trial tests how much fluid should be used to fill a stomach balloon to help people with overweight or obesity lose weight. The goal is to find which volume works best and is safest.

Stable isotope study in adults with obesity

This study uses a special test (stable isotopes) to learn about how adults with obesity process food and energy. It may help researchers understand weight and metabolism better.

Early help for healthy weight in young children

This trial tests a program to help families with young children build healthy habits and prevent obesity. It focuses on families facing challenges like low income or housing issues.

Grape study for immune and gut health in obesity

This trial tests if eating grapes every day for 4 weeks can improve your immune system and gut health. It is designed for adults with obesity who are willing to keep their diet and activity stable during the study.

Safety study of HRS9531 injection for teen obesity

This study tests whether a new injectable medication called HRS9531 is safe and well-tolerated in teenagers aged 12–17 with obesity. Researchers will monitor how your body handles the medication and whether it affects your weight.

Bed scale weight loss program for wheelchair users

This study tests if using a special bed scale helps wheelchair users lose more weight during a weight loss program. Participants will follow a weight loss plan, and half will get the bed scale to track their weight at home.