Clinical trials
Pain, Chronic Disease clinical trials
Below are recruiting pain, chronic disease clinical trials, each written for real people, not researchers. We’re tracking 470 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05537662Recruiting
Testing a wearable system to reduce diabetic nerve back pain
This study tests an Abbott device that uses sensing and electrical stimulation to help reduce chronic back and/or leg pain. It also tracks pain changes and diabetic control using wearables and regular questionnaires to see if the system improves outcomes.
Chicago, IllinoisAges 18 years+ - NCT05853640Recruiting
Education and exercise for long-term hip or groin pain
This trial tests whether a program of education plus exercise can reduce long-term hip or groin pain. It may help by improving movement and function, especially when pain has lasted more than 3 months.
MalmöAges 18–55 - NCT06263907Recruiting
Nerve block to prevent depression after mastectomy
This study tests whether a nerve block near the neck (stellate ganglion block) can help prevent depression after mastectomy for breast cancer. It is for women who are generally healthy and have no history of mood disorders.
Al MansurahAges 21–65 - NCT06404983Recruiting
Opioid-free anesthesia for breast cancer surgery
This study tests whether breast cancer surgery can be done safely without using opioid pain medicines during anesthesia. The goal is to see if avoiding opioids leads to fewer side effects and a smoother recovery.
Ioannina, EpirusAges 18–99 - NCT07677631Recruiting
Emotional allodynia in fibromyalgia: a questionnaire study
This study compares how people with fibromyalgia and those with other long-term pain conditions experience emotional pain (like feeling hurt by emotions). You will fill out a questionnaire about emotional sensitivity. The goal is to see if emotional allodynia (pain from emotions) is more common in fibromyalgia.
BariAges 18 years+ - NCT07448285RecruitingPhase 3
Platelet-rich plasma injection for chronic shoulder pain
This trial tests whether injecting platelet-rich plasma (a concentration of your own blood cells that may help healing) can reduce chronic shoulder pain. It's for people whose pain hasn't improved with standard painkillers and who have a specific shoulder tendon condition.
Barakaldo, BizkaiaAges 35–75 - NCT07507422Recruiting
Post-market study of Inceptiv spinal cord stimulation
This study follows people receiving Inceptiv, a spinal cord stimulator from Medtronic, to see how well it works over time. It is for adults with chronic back or limb pain who have not tried spinal cord stimulation before.
Phoenix, ArizonaAges 18 years+ - NCT07645859Recruiting
High-Intensity vs. Moderate Exercise for Chronic Lower Back Pain
This trial compares two types of exercise programs—one with short, intense bursts of activity and one with steady, moderate activity—to see which works better for people with long-lasting lower back pain that has no clear medical cause. You would participate in supervised exercise sessions over several weeks.
KarachiAges 20–48 - NCT07296653RecruitingEarly Phase 1
Prolotherapy for chronic low back pain
This trial tests a treatment called prolotherapy, which uses injections of a sugar solution into specific acupuncture points to help relieve chronic low back pain. It is for people who have had low back pain for at least 3 months, have not had previous back surgery, and have not received similar injections recently.
Athens, AtticaAges 35 years+ - NCT06892977Enrolling by invitation
How stress affects pain (brain scan study)
This study uses MRI scans to explore how stress changes your experience of pain. Researchers want to understand the link between stress and pain, which could help improve treatments for chronic pain.
GhentAges 18–45 - NCT04028687Recruiting
Study of a hip stem used in select adult hip replacements
This trial follows people who have had a hip replacement using a specific “Taperloc Complete” stem. It is meant to monitor outcomes after surgery and see how well the stem performs over time for certain non-infectious hip problems.
Henderson, NevadaAges 18 years+ - NCT05199870Enrolling by invitation
Long-term follow-up for specific hip implant parts
This study follows people who had a particular bipolar hip implant (RingLoc cup and/or Endo II head) placed during a hemi-hip replacement surgery at least 8 years ago. It checks how well the implants keep working over time and why.
Falls Church, VirginiaAges 18 years+ - NCT06771713Recruiting
Brief Pain Reprocessing Therapy for Veterans with Chronic Back Pain
This trial tests a type of talk therapy called Brief Pain Reprocessing Therapy for Veterans with long-term low back pain. The therapy is done over video calls, so you can join from home. It aims to help retrain how your brain processes pain signals.
Ann Arbor, MichiganAges 18 years+ - NCT06635902RecruitingPhase 2
Citrulline for sickle cell pain crisis
This trial tests if an intravenous medication called L-citrulline can help treat pain crises in children and young adults with sickle cell disease. Participants receive either the study drug or a placebo while in the hospital for a severe pain episode.
Washington D.C., District of ColumbiaAges 4–21 - NCT07630142Recruiting
Massage methods for chronic neck pain: an imaging study
This trial compares two types of massage—long, gentle strokes versus a handheld massager—for relieving long-lasting neck pain. Ultrasound imaging will be used to see how the muscles respond.
PoznanAges 18–60 - NCT07662733Recruiting
Acupuncture for better sleep and less pain after lung cancer surgery
This trial tests if acupuncture given before and after surgery can help patients sleep better and have less chronic pain after a lung cancer operation. You may join if you are having a specific type of lung cancer surgery, are in good general health, and do not have severe sleep problems already.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05812885Recruiting
TENS for long-lasting low back pain
This study tests whether transcutaneous electrical nerve stimulation (TENS), a non-drug pain treatment using small electrode pads on the skin, can help people with low back pain. You may be eligible if your back pain has lasted at least 3 months and your pain is at least moderate.
West Hartford, ConnecticutAges 18–60 - NCT05172739RecruitingPhase 4
Opioid-free anesthesia during lung surgery for early lung cancer
This study tests whether an opioid-free pain/anesthesia plan during elective lung surgery can reduce surgical “stress” on the body and affect the immune system. You may be eligible if you have early-stage non-small cell lung cancer and are scheduled for a specific type of surgery (VATS lobectomy).
Heraklion, CreteAges 18–80 - NCT06921694Recruiting
Exercise program for lower back pain
This trial tests a combined exercise program with stretching, strength, and aerobic exercises to help relieve chronic lower back pain. It looks at whether specific movements can reduce pain and improve daily function.
Nottingham, NottsAges 18–45 - NCT04556890Recruiting
Brain stimulation for treatment-resistant depression and chronic pain
This study tests a non-invasive brain stimulation treatment, called transcranial magnetic stimulation (TMS), to see if it can help people who have both major depression that hasn't improved with medication and chronic pain from fibromyalgia or chronic fatigue syndrome. It aims to reduce both depression and pain symptoms.
Los Angeles, CaliforniaAges 18–75 - NCT07109843Recruiting
Boswellia for pain and sensitivity in healthy volunteers
This trial tests whether a supplement called Boswellia serrata (frankincense) can change how your body processes pain and touch. It is for healthy people who do not have chronic pain or use certain medications.
Graz, StyriaAges 18 years+ - NCT07294651Recruiting
Needle treatment for chronic neck pain
This trial is testing a procedure called percutaneous electrolysis, where a tiny needle is used to treat painful trigger points in the upper neck muscles. It may help people with long-lasting neck pain.
SivasAges 18–70 - NCT06271447Recruiting
Pain questionnaire study for chronic low back pain
This study looks at how well pain questionnaires measure changes in chronic low back pain over time. If you have had long-term low back pain, researchers want to see if these surveys can accurately detect meaningful improvements.
Istanbul, None SelectedAges 18–65 - NCT06874816Recruiting
Neck pain, teeth grinding, and mouth behaviors study
This trial looks at how chronic neck pain is linked to teeth grinding (bruxism) and other mouth-related habits. It aims to see if muscle thickness in your jaw is related to your neck pain.
Istanbul, BeylikdüzüAges 18–65
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Common questions
- Are there clinical trials for pain, chronic disease?
- Yes. Clin2 currently lists 470 recruiting pain, chronic disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain, chronic disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain, chronic disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.