Clinical trials
Pain, Chronic Disease clinical trials
Below are recruiting pain, chronic disease clinical trials, each written for real people, not researchers. We’re tracking 469 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06874816Recruiting
Neck pain, teeth grinding, and mouth behaviors study
This trial looks at how chronic neck pain is linked to teeth grinding (bruxism) and other mouth-related habits. It aims to see if muscle thickness in your jaw is related to your neck pain.
Istanbul, BeylikdüzüAges 18–65 - NCT07021586Recruiting
Tongue pressure in adults with chronic neck pain
This study looks at how tongue pressure might be related to chronic neck pain in people aged 50 to 65. If you have ongoing neck pain, it could help researchers understand how your muscles work.
TaipeiAges 50–65 - NCT02991625Enrolling by invitation
Brain scan study to find markers for chronic back pain
This study uses brain imaging (MRI scans) to look for “biomarkers” (measurable signs) that may relate to chronic low back pain. It compares people with long-lasting back pain to healthy volunteers to understand what brain patterns are linked to pain.
Halifax, Nova ScotiaAges 18–75 - NCT07544108Recruiting
Understanding What Affects Neck Pain Recovery
This study helps researchers understand which patients with long-term neck pain recover better and why. By learning more about your neck pain and how it affects your daily life, the study may help doctors predict outcomes and improve treatment.
Kütahya, KütahyaAges 18–65 - NCT07352384Enrolling by invitation
Brain stimulation for chronic face and mouth pain
This trial tests if a non-invasive brain stimulation technique (called TMS or tDCS) can help reduce long-lasting pain in the face, jaw, or mouth. It's for people who have tried other treatments without enough relief.
Almada, Setúbal DistrictAges 18–75 - NCT06100926Enrolling by invitation
Virtual reality for chronic muscle pain
This study tests whether virtual reality (VR) can help reduce chronic muscle pain that is not caused by cancer. If you have fibromyalgia or similar long-lasting muscle pain, you may be able to join.
Udine, Friuli Venezia GiuliaAges 18–50 - NCT07368920Recruiting
TENS for low back pain in adults
This study tests if a non-invasive device called TENS (which uses gentle electrical pulses) can help relieve low back pain that comes from muscle knots or tight bands. The device is applied to the skin over the painful area.
Xi'an, ShaanxiAges 18–65 - NCT04995224Recruiting
Study what causes long-term pain in new Crohn’s or colitis
This study looks at why some people develop long-term pain after being newly diagnosed with ulcerative colitis or Crohn’s disease. It may help researchers understand the pain process and improve future treatments.
LondonAges 18 years+ - NCT05152264Recruiting
TENS device study for endometriosis-related chronic pain
This study tests whether a skin-applied electrical nerve pain-relief device (TENS) can help with long-lasting pain from endometriosis. It mainly looks at people who have confirmed endometriosis and are on stable hormone treatment.
GothenburgAges 18–100 - NCT06214923Recruiting
Virtual reality for jaw pain caused by TMD
This study tests whether immersive virtual reality can reduce chronic jaw pain from Temporomandibular Disorder (TMD). It uses EEG to see how VR affects brain activity related to pain.
Baltimore, MarylandAges 18–88 - NCT06690060Recruiting
Mind-body program for chronic migraine
This study tests whether a mind-body program, done remotely, can help people with chronic migraines reduce headache impact. It is for adults who have migraines at least 5 days a month and are willing to learn relaxation and stress-management techniques.
Boston, MassachusettsAges 18 years+ - NCT07057063Recruiting
Light therapy for knee pain and swelling
This study tests if light therapy can reduce knee pain and swelling (synovitis) caused by arthritis. If you have long-lasting knee pain and arthritis, this treatment might offer a non-drug option to help you feel better.
ShenzhenAges 40–80 - NCT05851196Recruiting
Personalized exercise for recurrent low back pain
This study looks at how back muscle features can help tailor an exercise program for people with recurring, non-specific low back pain. It may help by matching exercises to your specific back function and symptoms.
DiepenbeekAges 18–60 - NCT06763653Recruiting
Low-frequency device for chronic low back pain
This trial tests a new device that uses very low-frequency electrical pulses to treat chronic low back pain. It is for people whose pain hasn't improved with other treatments and who are not candidates for stronger therapies.
Norwood, South AustraliaAges 22 years+ - NCT05811624Recruiting
Lifestyle program for weight and chronic low back pain
This trial studies whether a lifestyle change program (often diet and activity habits) can reduce long-lasting low back pain in overweight or obese adults. It also aims to see if people can keep their usual care while adding the lifestyle program.
BrusselsAges 18–65 - NCT07742111Recruiting
Virtual reality for long-term low back pain
This study tests whether virtual reality exercises can help people with chronic low back pain feel better and move more comfortably. You might join if you have had low back pain for a while, your pain is moderate, and you have some fear of movement.
AmaranteAges 18 years+ - NCT06502873Recruiting
Study of colon samples in IBD and healthy people
This study is gathering information from people with active Crohn's disease or ulcerative colitis, and from people without IBD. Researchers will look at samples from the colon to learn more about these conditions.
LiègeAges 18 years+ - NCT07264270RecruitingPhase 1
A new injection for long-term sciatica pain
This trial tests a new medicine called C-1101, given as a shot into the spine, to see if it safely reduces pain from chronic sciatica. It is for people who have not gotten enough relief from standard treatments.
Broadmeadow, New South WalesAges 18–65 - NCT07491315Recruiting
Do ME/CFS patients react differently to exercise?
This study looks at whether people with ME/CFS have a different reaction to exercise compared to people with heart conditions who also feel tired. It involves filling out online questionnaires and may help doctors better understand ME/CFS.
MarseilleAges 18 years+ - NCT06008704Recruiting
PET scan study of pain in Parkinson's disease
This study uses a special brain scan (PET) to look at the serotonin system in people with Parkinson's who have chronic pain. The goal is to understand why some people feel pain and how the brain chemical serotonin might be involved.
Toulouse, Haute-GaronneAges 40–80 - NCT05843890Recruiting
Personalized pain guide for chronic low back pain
This study tests a tailored (personalized) pain guide to help people with long-lasting lower back pain. It may help by teaching strategies to reduce how pain interferes with daily life.
Ann Arbor, MichiganAges 18 years+ - NCT02653079Recruiting
Blood testing and low-dose radiation for painful joint conditions
This study collects blood samples and treats certain painful joint/soft-tissue problems with low-dose local radiation therapy. It aims to understand disease features and how patients may respond to this treatment.
Erlangen, BavariaAges 18 years+ - NCT06374238Recruiting
Peer Support for Young People with Sickle Cell Pain
This study is testing a peer support program for teens and young adults (ages 16–30) with sickle cell disease who have chronic pain. You'll connect with a trained peer supporter through your smartphone to learn pain coping skills and get support.
Mobile, AlabamaAges 16–30 - NCT03877653Recruiting
Freedom-1 treatment for long-term knee pain in adults
This study tests a procedure called Freedom-1 to reduce long-term, limiting knee pain from knee arthritis. It may help if other non-surgical options didn’t work and you meet specific knee and health requirements.
Placentia, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for pain, chronic disease?
- Yes. Clin2 currently lists 469 recruiting pain, chronic disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain, chronic disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain, chronic disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.