Clinical trials
Pain Management clinical trials
Below are recruiting pain management clinical trials, each written for real people, not researchers. We’re tracking 349 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07316166RecruitingPhase 4
Nerve Block With or Without Extra Medicine for Hip Replacement
This trial compares two types of nerve blocks for pain relief after total hip replacement. One block uses a standard numbing medicine, and the other adds a medication (dexmedetomidine) that may extend the pain relief. The goal is to see which approach works better for managing pain after surgery.
Providence, Rhode IslandAges 18–80 - NCT07373210Recruiting
Placebo pills for hip surgery pain in teens and young adults
This study tests whether taking placebo pills (pills with no active drug) can help manage pain after a specific hip surgery, called Bernese Periacetabular Osteotomy (PAO), in people with a hip condition called developmental dysplasia. The goal is to see if using placebos can reduce the need for pain medications and help with recovery.
San Francisco, CaliforniaAges 13–40 - NCT07231926Recruiting
Spinal morphine for recovery after keyhole lung surgery
This trial tests whether giving a small dose of morphine into the fluid around the spinal cord (intrathecal) can improve pain relief and recovery after keyhole lung surgery. It aims to help patients feel better faster and have fewer complications.
ErzurumAges 18–70 - NCT07388745Recruiting
Comparing two pain blocks for heart bypass surgery
This study compares two different nerve-block injections (one near the spine, one under the shoulder blade) to see which provides better pain relief after heart bypass surgery. If you are scheduled for a planned bypass and are in reasonably good health, you might be able to join.
KütahyaAges 45–85 - NCT07716540Recruiting
Pain relief injection for hip fracture surgery
This study tests whether a special numbing injection (deep iliacus plane block) can better control pain after hip fracture surgery. If you're having hip surgery under spinal anesthesia, researchers want to see if this extra block helps you recover with less pain.
Istanbul, IstanbulAges 18 years+ - NCT07695987Recruiting
Nerve block for pain relief after back surgery
This trial tests a nerve block called Quadro-Iliac Plane Block to reduce pain after a single-level lumbar microdiscectomy (back surgery). The block is given before surgery and may help you need less pain medicine and recover more comfortably.
Istanbul, IstanbulAges 18–75 - NCT03353584Recruiting
Virtual reality for pain relief during sickle cell pain crises
This trial tests whether a virtual reality (VR) experience can help reduce pain during a sickle cell “vaso-occlusive crisis,” which is an episode of sudden, severe pain. It’s offered alongside the care team’s usual pain management to see if VR makes pain feel better.
Memphis, TennesseeAges 6–25 - NCT03834818Recruiting
Using a phone app to track pain after orthopedic surgery
This study collects information about pain and recovery after planned (elective) orthopedic surgery. It uses a smartphone to help understand outcomes and pain levels so care may improve.
Durham, North CarolinaAges 18–90 - NCT03867539RecruitingPhase 4
Numbing shot and education to reduce opioids after carpal tunnel surgery
This study tests whether giving a long-lasting numbing injection (Exparel) plus education about pain management can help people avoid taking opioid pain pills after carpal tunnel release surgery. It may help reduce opioid use while still supporting comfort during recovery.
Dayton, OhioAges 18 years+ - NCT04979338RecruitingPhase 3
Opioid-sparing pain control for gender-affirming surgery
This Phase 3 study tests ways to manage pain during and after gender-affirming surgery while using less opioid medicine. It may help improve comfort after surgery and reduce opioid-related side effects.
Los Angeles, CaliforniaAges 18 years+ - NCT04990713Recruiting
Compare two pain-blocking methods during lung surgery
This study tests two different ways of numbing the chest to reduce pain during video-assisted lung surgery (VATS). It may help some people have less pain after surgery while still allowing the surgeon to do the operation safely.
London, OntairoAges 18 years+ - NCT05427058Recruiting
Nerve blocks to treat hard-to-control cancer pelvic pain
This trial tests two types of pain-relieving nerve blocks for people with severe cancer pain in the pelvis or perineum that has not improved enough with standard stepwise pain medicines. It may help reduce pain and lessen bothersome side effects from pain pills.
Malang, East JavaAges 18 years+ - NCT05452694Recruiting
Personalized pain relief after back fusion surgery
This trial tests a personalized plan to manage pain after lumbar (lower back) fusion and decompression surgery. It may help reduce difficult pain while guiding safe use of opioids around the time of surgery.
Pittsburgh, PennsylvaniaAges 18–99 - NCT05525923Recruiting
Personalized pain plan after chest surgery in adults
This trial tests a personalized (tailored) plan to manage pain after thoracic (chest) surgery. It may help improve comfort and recovery by matching pain treatment to your situation after surgery.
Pittsburgh, PennsylvaniaAges 18–99 - NCT05592132Recruiting
Virtual reality to help children handle cancer treatment pain
This trial studies whether virtual reality can reduce pain and discomfort during painful medical procedures for children getting care for benign (non-cancerous) tumors or cancer. It may help make treatments feel easier for you and your child during procedures.
Saint-DenisAges 6–18 - NCT06067958RecruitingPhase 3
Nose spray medicine for pain during eye exams in preemies
This study tests a nose spray medicine (dexmedetomidine) to help reduce pain and discomfort in premature babies who need eye exams for retinopathy of prematurity (a condition that can affect vision). The goal is to see if the spray works better than the usual care for calming babies during the exam.
Be’er Ya‘aqov, CenterAges 4 weeks+ - NCT06406647Recruiting
Nerve block for arm surgery
This trial tests a nerve block to help with pain during and after upper arm surgery. The goal is to see if it works well and is safe for patients.
AsyutAges 20–65 - NCT06406712Recruiting
Nerve block for arm vascular surgery
This trial tests a nerve block to numb the arm during vascular surgery. It may help manage pain and reduce the need for general anesthesia.
AsyutAges 20–65 - NCT06429501RecruitingPhase 2
Numbing medicine for facial fracture surgery
This study tests numbing medicine (local anesthetic) given during surgery for broken facial bones, like the jaw or cheekbones. The goal is to see how well it works and if it helps recovery.
St Louis, MissouriAges 18 years+ - NCT06488183Recruiting
Pain relief study for laparoscopic weight loss surgery
This study compares two ways to manage pain after laparoscopic bariatric surgery: one method involves numbing medicine placed near the surgery site, and the other uses an ultrasound-guided injection near the back. It aims to find which option works better for recovery in people with moderate to severe obesity.
AlexandriaAges 20–50 - NCT06545409Recruiting
Nerve block for pain relief in robotic thymus surgery
This trial tests a nerve block to reduce pain after robotic thymus surgery. It may help patients with thymus growths or cysts have less pain and use fewer painkillers after their operation.
RomeAges 18 years+ - NCT07267052Recruiting
Nerve stimulation at acupoints for pain relief
This trial uses a gentle electrical device on acupuncture points to study how it affects pain signals in the body. Healthy adults can join to help researchers understand a possible drug-free way to manage pain.
Taichung, Beitun, TaiwanAges 20 years+ - NCT06600815Recruiting
Step-by-step numbing shots for pain relief in knee replacement
This study tests whether a special step-by-step numbing injection given before knee replacement surgery can provide better pain relief during and after the procedure. It may help you have less pain and use fewer painkillers after surgery.
Fuzhou, FujianAges 18 years+ - NCT06639022Recruiting
Pain relief after cervical spine surgery
This study compares two types of nerve blocks to see which provides better pain relief after neck surgery. It looks for patients scheduled for a specific neck procedure called anterior cervical discectomy.
Altındağ, AnkaraAges 18–80
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Common questions
- Are there clinical trials for pain management?
- Yes. Clin2 currently lists 349 recruiting pain management studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain management trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain management trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.