Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,138 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06945263Enrolling by invitation
Comparing two freezing methods for pain after appendix removal
This study compares two ways of numbing the belly during laparoscopic appendix removal in children. It aims to find which method gives better pain relief after surgery.
Vancouver, British ColumbiaAges 4–18 - NCT06343714RecruitingPhase 1
Testing a new drug for knee osteoarthritis pain
This study tests a new antibody drug (FB1003) for people with knee osteoarthritis pain. It will check if the drug is safe and helps reduce pain. You may be eligible if you have moderate to severe knee pain and are willing to temporarily stop your usual pain medications.
Brisbane, QueenslandAges 18–75 - NCT06812832RecruitingPhase 4
Simethicone in bariatric surgery recovery
This trial tests if giving simethicone (a gas-relief medication) as part of a standard recovery plan helps patients feel better after weight-loss surgery. It may reduce bloating and discomfort after surgery.
Tacoma, WashingtonAges 18–89 - NCT06845215Recruiting
Pain block comparison for abdominoplasty recovery
This trial compares two types of nerve blocks (TAP and ESP) to see which provides better pain relief after tummy tuck surgery. Both are injections near the abdominal muscles that numb the area, and you'll also have a patient-controlled pain pump.
Ankara, KeçiörenAges Any age - NCT06933498Recruiting
Nerve block for less pain meds in back surgery
This trial tests whether a nerve block (called an erector spinae plane block) given before surgery can reduce the amount of pain medicine and anesthesia needed during lumbar disc surgery. It may help people have less pain and fewer side effects.
AnkaraAges 18–75 - NCT06931951Recruiting
Acupuncture with medicine for knee pain after a car accident
This trial tests a type of acupuncture that injects medicine into specific points (pharmacopuncture) to treat severe knee pain from a recent traffic accident. It looks at whether this treatment is safe and effective for people who are already in the hospital for their injury.
DaejeonAges 19–69 - NCT06936800Enrolling by invitation
Pinaverium Bromide to Prevent Pain After Shock Wave Treatment
This trial tests if a drug called pinaverium bromide can help prevent pancreatitis and reduce pain after a procedure that uses shock waves to break up large gallstones in the pancreas. It may be an option for people with chronic pancreatitis and stones that are at least 5 mm wide.
Jinan, Wenhuaxi RoadAges 18–85 - NCT06784882RecruitingPhase 4
Continuous vs. single-injection nerve block for outpatient knee replacement
This trial compares two types of nerve blocks for pain control after total knee replacement. You will receive either a one-time injection or a continuous block that delivers medication through a small tube. The goal is to see which method provides better pain relief while allowing you to go home the same day.
La Jolla, CaliforniaAges 18 years+ - NCT06931743Recruiting
Electrical stimulation for pain after thyroid surgery
This trial tests if electrical stimulation can help reduce pain after thyroid surgery. It is for people who have at least moderate pain after their operation.
Shanghai, Changning DistrictAges 18 years+ - NCT06926322Enrolling by invitation
Treating dead baby molars with special medicines
This study tests different medicines to treat dead (necrotic) baby molars in children. The goal is to safely clean the infection and save the tooth so it can stay until it falls out naturally.
CairoAges 4–8 - NCT06928740Recruiting
Music app vs. gas for anxiety during back injection
This trial tests whether listening to a digital music app can reduce anxiety as well as a standard gas (laughing gas) does in people getting a CT-guided back injection for low back pain.
NîmesAges 18 years+ - NCT06924268Enrolling by invitation
Art therapy for mood and symptoms in palliative care
This trial tests whether a single art therapy session can improve mood and reduce symptom burden for patients in a palliative care unit. It aims to see if creative expression can help you feel better emotionally and physically.
Halifax, Nova ScotiaAges 18 years+ - NCT06912438Enrolling by invitation
Emotional release after dry needling for jaw and head pain
This study tests whether a dry needling technique (trigger point needling) can help release emotional tension and reduce pain from muscle knots in the head and neck. It may be a good option if you have jaw or headache pain related to muscle tightness.
Tel Aviv, IsraelAges 18 years+ - NCT06915909Recruiting
Robotic prostate surgery with low pressure gas for less pain
This trial tests whether using lower gas pressure during robotic prostate surgery can reduce pain after the operation. It aims to help men recover more comfortably.
Stevenage, HertfordshireAges 18–75 - NCT06920459Recruiting
Zimmer Biomet Shoulder Replacement Study
This study is testing a shoulder replacement system made by Zimmer Biomet to see how well it works for people with severe shoulder problems, like arthritis or fractures. If you qualify, you would receive the implant and be asked to come back for regular checkups to track your recovery.
PforzheimAges 20 years+ - NCT06915363Recruiting
BioPoly implant for knee cartilage repair
This trial tests a BioPoly implant to repair a small damaged cartilage spot in your knee. If you have a specific type of cartilage injury that didn't get better with other treatments, this implant may help relieve pain and improve function.
Fort Wayne, IndianaAges 30–65 - NCT06912646Recruiting
Laser therapy for foot pain from idiopathic neuropathy
This trial tests a laser device for temporary relief of foot pain from peripheral neuropathy when the cause is unknown. It may help if you have constant foot pain and are not diabetic.
Miramar, FloridaAges 22 years+ - NCT06920485Enrolling by invitation
Mouthwash after wisdom tooth surgery
This trial tests whether a mouthwash with hypochlorous acid can help healing after impacted wisdom tooth removal. It may reduce discomfort and speed recovery.
AnkaraAges 18–45 - NCT06919640Enrolling by invitationPhase 1
Psilocybin and brain implant study
This trial tests whether psilocybin (the active ingredient in magic mushrooms) affects brain activity in people who already have a brain-sensing device implanted. It may help researchers understand how psilocybin works in the brain.
San Francisco, CaliforniaAges 21–75 - NCT06915012Recruiting
Test of light therapy for long-term severe arthritis pain
This study tests a non-drug therapy called biophoton therapy to see if it can reduce chronic severe arthritis pain. It may be an option if you've had pain for at least 3 months and are not using certain medical implants.
Butler, PennsylvaniaAges 18–80 - NCT06920095Enrolling by invitation
Relaxation exercises for better sleep and less pain in lymphoma
This trial tests if progressive muscle relaxation exercises can help lymphoma patients sleep better, feel less tired, and have less pain. You will be guided through simple exercises using your phone.
Küçükçekmece, IstanbulAges 18 years+ - NCT06911437Enrolling by invitation
Knee pain relief with Chinese formula and massage
This study tests if combining a Chinese herbal formula called Xiaoyu Zhitong with a gentle drainage massage can reduce knee pain and swelling. It may help people whose knee symptoms are worse in cold, damp weather.
BeijingAges 25–70 - NCT06908538Recruiting
Cryo nerve block for pain after amputation
This study is testing a treatment called a cryo nerve block to reduce pain after amputation, including phantom limb pain. It will look at whether freezing the nerve during surgery helps people feel less pain and use less pain medicine.
Pittsfield, MassachusettsAges 18 years+ - NCT06336733RecruitingPhase 3
Trial of anakinra for FMF attacks in patients who refuse daily shots
This trial tests if taking anakinra (a targeted medicine) only when you have a painful FMF attack can help, instead of taking it every day. It is for people with Familial Mediterranean Fever (FMF) whose attacks continue despite taking colchicine, and who do not want daily injections.
ParisAges 6 years+
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,138 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.