Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,138 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06808022Enrolling by invitation
Back exercises before spine surgery
This trial studies whether doing back exercises before spine surgery helps improve recovery. If you are having spine surgery and can safely do physical therapy, you may be able to join.
La Jolla, CaliforniaAges 18 years+ - NCT06807866RecruitingPhase 4
Duloxetine for pain after hip replacement surgery
This trial tests if duloxetine, a medication that helps with nerve pain, can reduce pain after hip replacement surgery. It may help patients who are having a first-time total hip replacement.
Miami, FloridaAges 18 years+ - NCT06812247Recruiting
Therapy dog visits for hospitalized trauma patients
This study looks at whether visits from therapy dogs can help people who are in the hospital after a traumatic injury feel better. You must be able to talk to the research team and not be afraid of dogs.
Boston, MassachusettsAges 18 years+ - NCT06800703Recruiting
Opioid use, pain, and the brain
This study uses brain scans (MRI) to understand how pain affects people with opioid use disorder or regular opioid use, compared to healthy volunteers. It aims to find better ways to treat both pain and opioid addiction.
New Haven, ConnecticutAges 21–60 - NCT06799052Recruiting
Cervical preparation for same-day abortion procedure
This study compares two methods of preparing the cervix (the opening to the uterus) on the same day as a dilation and evacuation (D&E) procedure for abortion at 16 to 18 weeks of pregnancy. The goal is to see which preparation approach works best and is safest.
Boston, MassachusettsAges 16 years+ - NCT06800846Enrolling by invitationPhase 4
Pain relief after knee replacement: injection methods compared
This study compares two ways to give pain medicine during knee replacement surgery: one is injected into the bone, the other around the joint. Researchers want to see which works better and may help you recover with less pain.
Khlong Luang, Changwat Pathum ThaniAges 50–80 - NCT06803485RecruitingPhase 4
Comparing two antidepressants for pain-related somatic symptom disorder
This trial tests whether venlafaxine or dosulepin works better for people whose main problem is pain from a condition called somatic symptom disorder. You may join if you are 18–65, have not recently taken similar medication, and do not have other serious health issues.
Bhubaneswar, OdishaAges 18–65 - NCT06796985RecruitingPhase 1
Botox for Chronic Pelvic Pain in Women
This study tests whether a Botox injection into the pelvic floor muscles can reduce chronic pelvic pain. It is for women who have had pelvic pain for at least 6 months, with tender muscle knots in the pelvic area.
Miami, FloridaAges 18–75 - NCT06641102Recruiting
Healing track for chronic back pain
This trial tests a non-drug, talk-based therapy approach for chronic back pain. It may help you manage pain without medication, and all study activities can be done from home using your smartphone.
New York, New YorkAges 21–70 - NCT06789861RecruitingPhase 1
First test of TT5 in healthy volunteers and surgical patients
This is a first-in-human study testing a new medicine (TT5) in healthy people and patients recovering from surgery. It checks how the body handles the drug and whether it is safe to use for pain.
Adelaide, South AustraliaAges 18–55 - NCT06788717Enrolling by invitation
Study on Hip Revision Stem Performance
This study is checking how well a specific hip implant (the Comprehensive Revision Stem) works in people who need hip replacement. It helps make sure the implant is safe and effective over time.
Los Angeles, CaliforniaAges 18–100 - NCT06782464Recruiting
Freezing nerves for shoulder pain after stroke or brain injury
This trial tests if freezing certain nerves in the upper arm (cryoneurolysis) works as well as standard care for reducing shoulder pain and muscle tightness after a stroke or brain injury. It aims to improve function and ease caregiving tasks.
LuxembourgAges 18 years+ - NCT06424743Recruiting
Strength training volume for women with fibromyalgia
This study tests whether different amounts of strength training (resistance exercise) help women with fibromyalgia feel better. It compares three different workout volumes to see which one women prefer and which works best for their symptoms.
Natal, Rio Grande do NorteAges 18–65 - NCT06778447Recruiting
Trial of disc tissue injection for degenerative disc disease
This study tests an experimental treatment that injects donated disc tissue (called an allograft) into damaged discs in your lower back. It's designed for people with chronic low back pain from disc degeneration who haven't found relief from non-surgical treatments.
Napa, CaliforniaAges 22–85 - NCT06776159Recruiting
Standardizing blood thinner shots for heart patients
This study tests whether a standard way of giving blood thinner shots (LMWH) to people with heart disease in the cardiac care unit improves care. It is for Chinese patients who are awake and can make their own decisions.
Hong KongAges 18 years+ - NCT06778005Recruiting
Ultrasound of leg nerves in type 2 diabetes with nerve damage
This study uses ultrasound (an imaging test) to measure the nerves in the legs of people with type 2 diabetes who have nerve damage. It helps doctors learn more about how diabetes affects nerves.
Istanbul, ÜsküdarAges 18–65 - NCT06777381Enrolling by invitation
Pain after root canal treatment in lower molars
This study compares how much pain people feel after a single root canal treatment on a lower back molar. It may help find a way to reduce discomfort after the procedure.
CairoAges 25–45 - NCT03976180Recruiting
High-flow oxygen for painful sickle cell episodes
This trial tests whether giving high-flow oxygen can help treat a painful sickle cell “vaso-occlusive crisis” (VOC) and lower the risk of a serious lung complication. You may be eligible if you’re an adult with sickle cell disease experiencing an opioid-requiring pain flare and have higher risk for lung trouble.
CréteilAges 18 years+ - NCT06770634Recruiting
Pain sensitivity and related factors in lipedema
This study looks at how pain sensitivity (central sensitization) affects people with lipedema. It aims to understand what factors are linked to increased pain in this condition, which might help improve care.
Istanbul, ÜsküdarAges 18–65 - NCT06762275Recruiting
New way to diagnose appendicitis in children with belly pain
This study looks at a new way for general practitioners (GPs) to diagnose appendicitis in children with belly pain. It aims to find out if a special checklist or test can help GPs decide which children need to go to the hospital, potentially saving unnecessary trips.
Groningen, Provincie GroningenAges 4–18 - NCT06754111Enrolling by invitation
Can the birth environment help with pain and fear?
This study looks at how the birth environment (like a calm, comfortable room) affects pain, fear, how you give birth (vaginal or C-section), and how long labor lasts. It's for first-time mothers who are healthy and not high-risk.
Burdur, BucakAges 18–35 - NCT06757075RecruitingPhase 4
Managing pain after children's dental surgery
This study tests different ways to manage pain in young children after dental surgery done under general anesthesia. It aims to find the best method to keep children comfortable and reduce discomfort.
Brighton, MassachusettsAges 4–6 - NCT06758973Enrolling by invitation
Turkish pain anxiety scale study
This study is testing a short Turkish questionnaire about how pain affects your emotions. If you have chronic pain (lasting at least 3 months) that happens 4 or more days a week and is at least a 3 out of 10 in intensity, you may be able to help.
Kırşehir, MerkezAges 18–65 - NCT06087510RecruitingPhase 4
Different doses of esketamine and dexmedetomidine for pain after scoliosis surgery
This trial tests two different doses of esketamine and dexmedetomidine to see which provides better pain relief after scoliosis correction surgery. It aims to improve your recovery and long-term outcomes.
Beijing, Beijing MunicipalityAges 18 years+
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,138 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.