Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,138 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06032559RecruitingPhase 3
Mindfulness and methadone for chronic pain
This study tests if adding a mindfulness program (MORE) to regular methadone treatment helps people with long-term pain. It may improve pain and support recovery.
New Brunswick, New JerseyAges 18 years+ - NCT06448923RecruitingPhase 2
CBD for Pain and Opioid Reduction After Fracture
This trial tests if cannabidiol (CBD) can help reduce pain and the need for opioids after a broken arm or leg. If you recently broke a bone and are between 18 and 70, you might be able to join.
Montreal, QuebecAges 18–70 - NCT06748976Recruiting
Brain activity study during attention tasks
This study looks at how your brain controls attention by measuring brain activity while you perform tasks. It may help researchers understand attention better.
Oro Verde, Entre Ríos ProvinceAges 18–60 - NCT05762250Recruiting
Ear acupuncture for symptom relief in advanced cancer
This study tests whether auricular (ear) acupuncture can reduce ongoing symptoms and daily limitations in people with advanced cancer. It may help with discomfort and other side effects related to the disease or its treatment.
StuttgartAges 18–70 - NCT06744816RecruitingEarly Phase 1
Can capsaicin cream ease nerve pain after chemotherapy?
This study tests whether a capsaicin cream (made from chili peppers) can help reduce pain in the legs caused by nerve damage from past chemotherapy. It's for people who still have pain 3 months or more after finishing chemo.
Houston, TexasAges 18 years+ - NCT06745388RecruitingPhase 4
Magnesium for cramping during hysteroscopy or D&C
This study tests whether magnesium can reduce cramping during a hysteroscopy or D&C. If you are having one of these procedures and are not on certain medications, you may qualify.
Royal Oak, MichiganAges 18 years+ - NCT06744257Recruiting
Online education for kneecap pain while waiting for physio
This trial tests whether an online education program is helpful for people with kneecap pain who are waiting for in-person physiotherapy. It aims to see if this approach is practical and beneficial.
ColchesterAges 16–44 - NCT06740214RecruitingPhase 3
Different doses of liposomal bupivacaine for knee replacement pain
This trial tests different doses of a long-acting painkiller (liposomal bupivacaine) injected into a nerve block in the thigh to see which dose works best for pain after knee replacement surgery. It may help you have better pain control and recover faster.
Hong Kong, Hong KongAges 18–80 - NCT06266611RecruitingPhase 2
Cannabis for cancer symptom relief
This trial tests whether cannabis can help cancer patients manage symptoms like sleep trouble, pain, and mood changes. It's for people who are new to using cannabis for these issues.
Aurora, ColoradoAges 25 years+ - NCT06736795Recruiting
Online support for Achilles tendon loading exercises
This study tests whether extra support from a clinician during a progressive exercise program helps people with Achilles tendon pain improve faster. You'll do exercises that gradually increase the load on your tendon, with guidance from a physical therapist via video visits.
Iowa City, IowaAges 18–60 - NCT06729294Recruiting
Does music help during knee replacement surgery?
This study tests if listening to music during knee replacement surgery under spinal anesthesia can lower anxiety, pain, and stress hormone levels. It may help make the experience calmer for patients.
Kocasinan, KayseriAges 18 years+ - NCT06731998Recruiting
Improving pain control after cancer surgery
This study compares different methods of managing pain after minimally invasive surgery for abdominal cancers. It aims to find which approach works best to reduce pain and improve recovery.
Pittsburgh, PennsylvaniaAges 18–89 - NCT06729437Recruiting
Transcranial brain stimulation for patellar tendon pain
This trial tests whether a gentle brain stimulation technique called transcranial direct current stimulation (tDCS) can improve knee function and reduce pain in people with long-term patellar tendinopathy (jumper's knee). It may help by calming pain signals in the brain.
Valencia, ValenciaAges 18–50 - NCT06736483RecruitingPhase 2
Dexmedetomidine for children’s groin surgery recovery
This trial tests whether adding a sedative called dexmedetomidine to a numbing shot (nerve block) helps children aged 1–7 recover better after groin surgery. The goal is to improve comfort and reduce side effects.
Montpellier, FranceAges 1–7 - NCT06012097RecruitingPhase 4
Aromatherapy gel for De Quervain's wrist pain
This trial tests if a gel made with essential oils can help reduce pain from De Quervain's disease, a painful wrist condition. If it works, it could be a natural option to relieve discomfort.
StrasbourgAges 18–75 - NCT06265636Recruiting
Nerve stimulation for jaw pain and function in TMD
This trial tests whether gentle electrical stimulation of a nerve in your jaw can reduce pain and improve chewing, talking, and mouth opening for people with temporomandibular joint disorder (TMD).
Alcorcón, MadridAges 18–65 - NCT06717308Recruiting
Testing a gentler adhesive drape for wound therapy
This trial compares a special adhesive drape (the switchable one) with the standard drape during negative pressure wound therapy (a treatment that uses suction to help heal wounds after surgery). The goal is to see if the new drape causes less pain when removed.
Los Angeles, CaliforniaAges 18 years+ - NCT06718296Recruiting
Photographic Shoulder Pain Scale Study
This study is creating a new way to measure shoulder pain using pictures. It is for people who have had shoulder pain for more than 3 months, whether from an injury or other causes.
IstanbulAges 18–64 - NCT06721000Enrolling by invitation
Patient-controlled vs. standard epidural pain relief
This trial compares two types of epidural pain management during surgery. It tests whether letting you control your pain medication yourself works better than the standard method.
Karachi, SindhAges 19 years+ - NCT06723158Recruiting
Virtual reality glasses for oral surgery with sedation
This trial tests if wearing virtual reality (VR) glasses during oral surgery helps patients relax while under IV sedation. It may be a good option if you need sedation for a tooth extraction or other mouth procedure.
Boston, MassachusettsAges 16–65 - NCT06718569Recruiting
Pain in Inflammatory Joint Diseases
This study looks at pain in people with inflammatory joint diseases. It aims to understand how pain changes when you start or switch to a newer type of arthritis medication.
OsloAges 18 years+ - NCT06721819RecruitingPhase 3
Sleep and brain training before heart surgery to prevent delirium
This study tests whether a combination of sleep therapy, brain games, and light exercise before heart surgery can help prevent confusion or disorientation (delirium) after the operation. Participants will be asked to use a tablet and fitness tracker daily for about an hour before their surgery.
Boston, MassachusettsAges 60 years+ - NCT06718413RecruitingPhase 2
Study on shoulder pain after stroke
This study tests a treatment for shoulder stiffness and pain caused by muscle tightness after a stroke. It focuses on people who still have some limited shoulder movement and may help improve range of motion and comfort.
Baltimore, MarylandAges 18 years+ - NCT05969561Recruiting
Ultrasound-guided nerve block for hip-fracture pain in the ER
This trial tests whether an emergency doctor can safely and effectively place a pain-relieving nerve block in the thigh using ultrasound for people with hip fractures. It may help reduce pain while you are in the emergency department.
Douliu, Yunlin CountyAges 20 years+
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,138 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.