Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,138 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06875895Recruiting
Motor imagery training for partial rotator cuff tears
This trial tests whether mental practice of shoulder movements can reduce pain and improve function in people with a partial rotator cuff tear. If you have shoulder pain that hasn't gone away after 4 weeks, this could be an option.
KütahyaAges 18–65 - NCT06860867Recruiting
Nucleus replacement for single-level discogenic low back pain
This trial tests a new device called PerQdisc for people with chronic low back pain from a single damaged disc in the lower spine. The goal is to see if the device can safely replace the inner gel of the disc without major surgery.
Glendale, ArizonaAges 22–70 - NCT06859697Enrolling by invitation
Herbal medicine for obesity with spine or joint pain
This trial tests whether herbal medicine can safely help with pain and weight loss in people who have both obesity (BMI 25 or higher) and back or joint pain. It aims to see if the treatment works and is safe.
Seoul, Gangnam-GuAges 19–69 - NCT06859723RecruitingPhase 1
Effects of high potency cannabis on daily users
This study tests how high potency cannabis affects mood, thinking, and pain sensitivity in people who smoke cannabis almost every day. It will help researchers understand both immediate and long-lasting effects.
Los Angeles, CaliforniaAges 21–55 - NCT06862609Recruiting
Pain relief block for inguinal hernia surgery
This study tests a nerve block called QIPB to reduce pain after laparoscopic inguinal hernia repair. It is for adults having planned surgery on one side under general anesthesia.
KonyaAges 18–65 - NCT06861387Recruiting
Cryo nerve block for lung surgery pain
This trial tests a freezing technique to numb nerves around the lungs during minimally invasive lung surgery. It may help reduce pain after surgery, so you need less pain medication.
Nieuwegein, UtrechtAges 18 years+ - NCT06859710RecruitingPhase 1
THC and CBD as a harm reduction strategy
This study looks at whether different types of cannabis (containing THC and/or CBD) might help people who use cannabis regularly reduce potential harms. You will be asked to take cannabis in a controlled setting and complete tasks and questionnaires.
Los Angeles, CaliforniaAges 21–55 - NCT06866054Recruiting
A block for shoulder surgery pain relief
This trial tests a nerve block to reduce pain after arthroscopic shoulder surgery. It might help you have less pain and recovery time after the procedure.
Istanbul, BagcilarAges 18–75 - NCT05141591Recruiting
Anxiety before ENT surgery and opioid use after surgery
This trial looks at whether people’s anxiety before ear, nose, and throat (ENT) surgery affects how much pain medicine (opioids) they need after surgery. It may help doctors better plan pain control based on anxiety level and possibly gender-related patterns.
Vienna, State of ViennaAges 18 years+ - NCT06851910Recruiting
Lacosamide IV for acute trigeminal neuralgia pain
This trial is testing a medication called lacosamide, given through an IV, to treat sudden, severe facial pain attacks in people with trigeminal neuralgia who come to the emergency room. The goal is to see if it helps relieve pain quickly.
L'Hospitalet de Llobregat, BarcelonaAges 18 years+ - NCT06848023Enrolling by invitation
Shoulder replacement vs tendon repair in older adults
This study compares how well two different shoulder surgeries—reverse total shoulder replacement and rotator cuff repair—work for people 60 and older, at least one year after the operation. If you meet the age and surgery requirements, your results could help doctors decide which procedure is better for older adults.
Germantown, TennesseeAges 60–95 - NCT06852248Recruiting
Green dye vs. ureter stent for endometriosis surgery
This trial compares two ways of protecting the ureter during deep endometriosis surgery: placing a small tube (stent) versus using a green dye (indocyanine green) to see the ureter. The goal is to see if the dye works just as well but causes less pain and fewer side effects afterward.
Stoke-on-Trent, StaffordshireAges 18–50 - NCT05830279Recruiting
Personalized drug choices to better manage cancer treatment side effects
This trial tests a personalized approach to selecting drugs during cancer treatment. The goal is to improve how well your prescribed medicines work for symptoms and side effects while keeping you safe.
London, OntarioAges 18 years+ - NCT06837909Recruiting
Nerve block vs wound injection for breathing after kidney donation
This study compares two ways to manage pain after laparoscopic kidney donation surgery: a nerve block (injection near the belly muscles) versus injecting numbing medicine directly into the surgical wound. The goal is to see which method helps you breathe better after surgery.
Petah TikvaAges 18 years+ - NCT06837831Recruiting
Mepilex Lite Dressing for radiation skin damage on anal area
This trial tests a special wound dressing (Mepilex Lite) to treat skin burns from radiation therapy in patients with rectal cancer. It may help heal the skin around the anal canal more comfortably.
Jinan, ShandongAges 18 years+ - NCT06840262Recruiting
Nerve surgery for pain after cancer amputation
This study tests two surgical techniques—target muscle re-innervation and regenerative peripheral nerve interfaces—alone or together, to help reduce pain felt in the remaining limb or the missing limb (phantom pain) after amputation for cancer. The goal is to find the best way to manage pain and improve quality of life.
Houston, TexasAges 18 years+ - NCT04085406Recruiting
Deep brain stimulation for hard-to-treat low back pain
This trial studies deep brain stimulation (DBS) to reduce severe low back pain that hasn’t improved after many standard treatments and procedures. It may help people whose pain is long-lasting and not fixable with another surgery.
Los Angeles, CaliforniaAges 40–75 - NCT05427058Recruiting
Nerve blocks to treat hard-to-control cancer pelvic pain
This trial tests two types of pain-relieving nerve blocks for people with severe cancer pain in the pelvis or perineum that has not improved enough with standard stepwise pain medicines. It may help reduce pain and lessen bothersome side effects from pain pills.
Malang, East JavaAges 18 years+ - NCT06835582Enrolling by invitation
Checking Methadone and Its Breakdown Levels
This study is checking the levels of methadone and its breakdown products in your blood. It helps make sure the medication is working safely for conditions like opioid use disorder or chronic pain.
Lemon Grove, CaliforniaAges 18–70 - NCT06655675Recruiting
Blood flow changes after epidural pain relief in labor
This study looks at how a type of labor pain relief (combined spinal-epidural) affects blood flow in the mother and baby's main arteries. It may help doctors understand if this common pain relief method is safe for all labors.
Toronto, OntarioAges 18–50 - NCT05378841Recruiting
Surgery to reduce pain in finger osteoarthritis
This trial tests whether surgical “nerve disconnection” (joint denervation) can reduce pain from osteoarthritis in a finger joint. It focuses on people who have ongoing finger pain despite usual treatments for at least 3 months.
ParisAges 18 years+ - NCT06818396Recruiting
Pain relief for hip surgery: comparing two methods
This study compares two ways to manage pain during hip surgery: a nerve block in the groin area versus a spinal medication. The goal is to find which approach offers better pain control with fewer side effects.
CairoAges 21 years+ - NCT06814977Recruiting
Acupuncture for joint pain in cancer survivors
This study tests whether acupuncture can help reduce joint pain in cancer survivors. If you have bothersome joint pain that has lasted at least a month, acupuncture might offer relief.
New York, New YorkAges 18 years+ - NCT06812247Recruiting
Therapy dog visits for hospitalized trauma patients
This study looks at whether visits from therapy dogs can help people who are in the hospital after a traumatic injury feel better. You must be able to talk to the research team and not be afraid of dogs.
Boston, MassachusettsAges 18 years+
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,138 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.