Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,136 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06535178Recruiting
Sleep and heart health in fibromyalgia
This study looks at how sleep affects heart health in people with fibromyalgia (a condition causing widespread pain). Researchers will test if improving sleep can help your heart work better.
Portland, OregonAges 18–50 - NCT06539741Recruiting
Ibuprofen response study for wisdom tooth removal
This study looks at how people respond to ibuprofen after having one or more impacted wisdom teeth removed. It aims to understand why pain relief varies between individuals.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06538246Recruiting
Coping skills training for heart and lung failure survivors
This study tests a coping skills training program to help people who recently survived a serious heart or lung problem feel less anxious, depressed, or stressed. If you were in the ICU and now feel distressed at home, you may be able to join.
Durham, North CarolinaAges 18 years+ - NCT03725527Recruiting
Nerve block test to improve breathing after belly surgery
This trial studies whether a numbing injection near the abdominal muscle (rectus sheath block) helps your breathing and diaphragm function after elective upper belly surgery. If you qualify, you may receive or not receive this pain/nerve block as part of the study.
Asyut, Assiut GovernorateAges 18–50 - NCT06507293Recruiting
Pain relief methods comparison for lung surgery
This trial tests two numbing injections to see which reduces pain medicine use during lung surgery. A special pain monitor guides the treatment. It may help you need fewer opioids during your procedure.
KocaeliAges 18–65 - NCT06527183Recruiting
Fibromyalgia and small fiber nerve study
This study looks at whether people with fibromyalgia or long-term chronic pain have damage to the small nerve fibers in their skin. Understanding this could help develop better treatments.
Boulogne-BillancourtAges 18 years+ - NCT06525740RecruitingPhase 4
Comparing two pain medicines for gynecologic cancer surgery
This trial compares two different pain medicines (methadone given by mouth or IV vs. hydromorphone given through a spinal injection) after surgery for gynecologic cancer. It aims to find which option provides better pain relief with fewer side effects.
Rochester, MinnesotaAges Any age - NCT06529432RecruitingPhase 2
Study of a long-acting painkiller for lung surgery recovery
This trial tests a long-acting pain medication (bupivacaine liposome injection) to control pain after lung surgery done through a small cut. It may help you feel more comfortable and reduce the need for other pain medicines.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06224933Recruiting
Augmented reality for MRI-guided procedures in children
This study tests if augmented reality (a type of computer overlay) can help doctors perform MRI-guided needle procedures more accurately in children and young adults. It may lead to safer and more precise treatments.
Washington D.C., District of ColumbiaAges 3–21 - NCT06507748Recruiting
Measuring pain with a finger device in NF1
This study tests a new way to measure pain and other sensations in people with NF1 using a device that clips onto a finger or toe. The device looks at how your pupil reacts to mild pulses, which may help doctors better understand your pain.
Washington D.C., District of ColumbiaAges 1–120 - NCT06497712Recruiting
Hypnosis for pain during emergency room stitches
This trial tests if hypnosis can reduce pain when getting stitches in the emergency room. If you have a stitchable wound and are at least 18 years old, you may be able to join.
Clermont-FerrandAges 18 years+ - NCT06511401Recruiting
Pain treatment guided by your genes
This study looks at whether knowing your genetic makeup can help doctors choose the safest and most effective pain medicine for you before you start taking opioids. If you are being treated for cancer and may need opioid pain medication soon, this trial might be a fit.
Chicago, IllinoisAges 18 years+ - NCT06505187RecruitingPhase 2
Celecoxib for Pain After Parotid Gland Surgery
This trial is testing whether the pain reliever celecoxib (Celebrex) can help control pain after a specific type of salivary gland surgery called superficial parotidectomy. If you're having this surgery, you may be able to join and take celecoxib for pain rather than other common pain medicines.
Madison, WisconsinAges 18 years+ - NCT06513208RecruitingPhase 4
Ketorolac for pain after lower back fusion surgery
This trial tests if a non-steroidal anti-inflammatory drug (NSAID) called ketorolac can help reduce pain after lower back fusion surgery. It is for people who are having elective surgery to fuse one or two bones in their lower back.
Towson, MarylandAges 18–85 - NCT06511765RecruitingPhase 3
Nerve block for acute lower back pain: a pilot study
This study tests whether a single injection of a numbing medicine (ropivacaine) into the muscles of the lower back can quickly relieve sudden, severe back pain that has lasted less than a week. The goal is to see if this nerve block can help when standard pain pills aren't working.
Saint-HerblainAges 18 years+ - NCT06477796Recruiting
Improving sleep in veterans with TBI and sleep problems
This study tests a new way to help Veterans with both a traumatic brain injury (TBI) and sleep problems get better rest. If you are a Veteran with sleep trouble and a history of TBI, this program may help improve your sleep without needing extra medication.
Portland, OregonAges 18–89 - NCT06464146RecruitingPhase 3
Comparing nose and mouth pain medicines for broken bones in kids
This study compares three different fast-acting pain medicines given through the nose or by mouth to children with a suspected broken arm or leg in the emergency room. The goal is to find which medicine works best for pain relief within the first hour.
Boulogne-BillancourtAges 2–17 - NCT06446960RecruitingPhase 3
Nerve blocks for stroke-related central pain
This study tests whether numbing the nerves in your painful arm or leg (with a nerve block) can help reduce central pain after a stroke. It aims to find out how the nerves outside your brain and spinal cord may be involved.
Boulogne-BillancourtAges 18 years+ - NCT06453447Recruiting
Prednisone to prevent CRPS after wrist fracture surgery
This trial tests whether a short course of the steroid prednisone can prevent or reduce complex regional pain syndrome (CRPS) after wrist surgery. It is for people who had a broken wrist fixed with a plate and screws and have a higher chance of developing CRPS.
Vancouver, British ColumbiaAges 19 years+ - NCT06348719Recruiting
Robot vs. standard laparoscopy for early endometrial cancer
This trial compares two types of minimally invasive surgery (robot-assisted vs. conventional laparoscopy) for removing the uterus in people with early-stage, low- to intermediate-risk endometrial cancer. The goal is to see which approach offers the best value and outcomes.
LilleAges 18 years+ - NCT04893954Recruiting
Study of spine changes after weight loss from bariatric surgery
This study looks at how rapid weight loss after bariatric surgery may affect your spine over the following year or more. It may help doctors better predict who gets spine-related problems or improvements after surgery.
ParisAges 18 years+ - NCT06427356Recruiting
Team care for veterans with chronic pain at Salem VA
This study tests a team-based approach to help veterans with long-lasting pain. It looks at whether working with a group of specialists (like doctors, nurses, and mental health providers) can improve pain and daily life. It is for veterans already receiving care at the Salem VA who are part of the PREVAIL program.
Salem, VirginiaAges 18 years+ - NCT06368492Recruiting
Psilocybin for fibromyalgia pain
This trial tests whether psilocybin, a substance found in certain mushrooms, can help reduce pain in people with fibromyalgia. You would receive the drug and be monitored closely to see if it improves your pain levels.
Maastricht, LimburgAges 18–65 - NCT06425016Recruiting
Robot-assisted vs. traditional sleeve gastrectomy
This study compares two types of weight-loss surgery: one done with the help of a robot and the other done by hand (laparoscopic). Both are types of sleeve gastrectomy, where the stomach is reduced in size. If you qualify for sleeve gastrectomy, this trial may help doctors learn which method works better.
Cleveland, OhioAges 18–70
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,136 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.