Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,136 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05415384Recruiting
Cryotherapy plus surgery for broken ribs
This trial tests whether adding cryotherapy (freezing treatment to the injury area) to standard surgery for broken, displaced ribs can improve recovery. It’s for adults with multiple broken ribs who are getting a surgical stabilization procedure soon after injury.
Winston-Salem, North CarolinaAges 18–80 - NCT05400707Recruiting
Tracking symptoms and other clues in emergency room visits
This study follows people who come to the emergency department to see what symptoms and other factors can help predict what happens next. It may help improve how emergencies are quickly triaged and managed.
BaselAges 18 years+ - NCT05411523Recruiting
Spinal cord stimulation study for long-term chemotherapy nerve pain
This trial tests whether spinal cord stimulation can reduce pain and improve quality of life in people with long-lasting nerve pain from chemotherapy (CIPN). You must already have tried at least two nerve-pain medicines and still have significant pain, and you must have had a successful spinal cord stimulator test before joining.
Rochester, MinnesotaAges 18 years+ - NCT05351229RecruitingPhase 4
Spinal morphine for pain control after lung surgery
This trial tests whether putting morphine into the spinal area during lung surgery can reduce pain after surgery for people having certain minimally invasive lung operations. It aims to improve comfort and possibly reduce the need for other pain medicines.
Chicago, IllinoisAges 18–80 - NCT05260320Recruiting
Testing the best anesthesia plan for teens having jaw surgery
This study looks at whether a standardized anesthesia plan works best for kids and teens having Le Fort jaw surgery at Johns Hopkins. If you qualify, the team may use or adjust anesthesia to improve safety and comfort during surgery.
Baltimore, MarylandAges 14 years+ - NCT05272488Recruiting
Manual therapy plus vagus nerve stimulation for jaw muscle pain
This trial tests whether combining hands-on jaw treatment with a vagus nerve stimulator can reduce jaw muscle pain and improve jaw movement. It may help people whose jaw pain has been present recently and who have not had recent physiotherapy.
Alcalá de Henares, MadridAges 18 years+ - NCT05285566RecruitingPhase 4
Pain control during rib cartilage nose surgery
This trial studies a way to better control pain for people who need nasal surgery that uses rib cartilage. It may help reduce discomfort during the procedure and recovery.
Rochester, MinnesotaAges 18 years+ - NCT05303415Recruiting
Low-intensity ultrasound study during brain MRI
This study tests how low-power focused ultrasound changes brain signals measured during MRI. You may help researchers understand how ultrasound can affect brain activity, even if you don’t have a known brain condition.
Roanoke, VirginiaAges 18–65 - NCT05199870Enrolling by invitation
Long-term follow-up for specific hip implant parts
This study follows people who had a particular bipolar hip implant (RingLoc cup and/or Endo II head) placed during a hemi-hip replacement surgery at least 8 years ago. It checks how well the implants keep working over time and why.
Falls Church, VirginiaAges 18 years+ - NCT05245695Recruiting
Endometriosis test using deep computer learning during surgery
This trial studies whether a computer (deep neural network) can better identify endometriosis in people with long-lasting pelvic pain using information from surgery. It may help doctors sort who has endometriosis more accurately when surgery is already planned.
Chandler, ArizonaAges 14–50 - NCT05224726Recruiting
Platelet-rich plasma for healing after C-section
This study tests whether a treatment made from your own platelets (platelet-rich plasma) can help the uterus heal after an elective C-section. You may be considered if you are full-term and having a planned C-section.
Ramat Gan, CenterAges 18–52 - NCT05247255Enrolling by invitationEarly Phase 1
Nerve block during hip replacement surgery
This early-stage study tests whether a specific nerve block to numb the lower back area can make total hip replacement surgery more comfortable. It looks at patients who are having planned (elective) hip replacement and whether the nerve block is safe and works well.
Santa Monica, CaliforniaAges 18 years+ - NCT05179928Recruiting
Numbing injections for less pain after belly surgery
This trial compares two different numbing injection techniques to help control pain after surgery above the belly button. It may help people who qualify have better or longer-lasting pain relief with fewer side effects.
Damanhūr, El-BeheiraAges 21–60 - NCT05149573Recruiting
PEMF therapy for women with painful bladder symptoms
This trial studies whether a device that uses gentle pulsed electromagnetic waves (PEMF) can reduce symptoms in women with interstitial cystitis/bladder pain syndrome (IC/BPS). It may help if your symptoms are currently fairly severe and ongoing.
Winston-Salem, North CarolinaAges 18–80 - NCT05110989Recruiting
Registry study of pain relief after freezing intercostal nerves
This study collects real-world information about how well freezing (cryoablation) of the intercostal nerves helps with pain after a procedure. It may help doctors understand outcomes and improve care for future patients.
Jacksonville, FloridaAges 12 years+ - NCT05127265Recruiting
AI and sensors to monitor patients in the ICU
This study uses AI and sensor data to better monitor people while they are in an intensive care unit (ICU). It may help teams notice changes sooner and improve care for ICU patients.
Gainesville, FloridaAges 18 years+ - NCT05072314RecruitingPhase 3
Lidocaine drip after breast surgery to improve long-term pain
This Phase 3 study tests whether a long-running lidocaine (a numbing medicine) drip given around the time of breast surgery can improve long-term post-surgery pain and recovery. It may help people who have pain after mastectomy or breast-conserving surgery.
Kingswood, New South WalesAges 18 years+ - NCT05068791RecruitingEarly Phase 1
Psilocybin-assisted treatment for long-term body pain
This early trial studies whether psilocybin, given in a supported setting, can reduce long-term widespread musculoskeletal pain (including fibromyalgia-like symptoms). You would be monitored closely and need someone to take you home after the medicine session.
Birmingham, AlabamaAges 25–65 - NCT05024344Recruiting
Nerve block to reduce pain after kidney stone surgery
This trial tests whether an “ESP block” (a targeted local anesthetic injection near nerves) works better than standard care to control pain after percutaneous kidney stone removal. If it helps with pain, it could reduce the need for stronger pain medicines after surgery.
Knoxville, TennesseeAges 18 years+ - NCT05023369RecruitingPhase 4
Hip replacement patients may get an added steroid injection
This trial tests whether a steroid injection placed around the hip after hip replacement can reduce pain and shorten hospital stay. It is meant for older adults who are having hip replacement due to a broken femoral neck bone.
LuganoAges 50–90 - NCT05020028RecruitingPhase 2/Phase 3
CBD to reduce knee pain from osteoarthritis
This study tests cannabidiol (CBD) to help lower pain from knee osteoarthritis. It may be an option if you have ongoing knee pain and meet age, safety, and medication guidelines.
New York, New YorkAges 40–75 - NCT04984291Recruiting
Study of shoulder replacement implants for eligible adults
This trial looks at a specific shoulder replacement implant and follow-up care for people who need a shoulder arthroplasty (shoulder replacement) for certain joint problems or fractures. You may be a candidate if you can take part in required visits and your shoulder muscles and bone are suitable.
Irvine, CaliforniaAges 20 years+ - NCT04964206Recruiting
Epidural pain relief in labor and baby brain development
This trial studies how epidural pain relief during vaginal labor may affect a child’s early brain and development. It’s for first-time, term pregnancies where you plan a vaginal birth.
Beijing, Beijing MunicipalityAges 18–35 - NCT04939623RecruitingPhase 2
Probenecid to ease opioid withdrawal symptoms while tapering
This Phase 2 study tests whether probenecid can lessen discomfort from opioid withdrawal in adults who are gradually lowering their opioid pain medicine. If it works, it may make tapering feel more tolerable and safer.
Calgary, AlbertaAges 18–80
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,136 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.