Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,136 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04929951RecruitingPhase 1
Micro fat injection to treat shoulder arthritis
This Phase 1 study tests whether a micro-fragmented fat (MFAT) injection can reduce symptoms and improve shoulder function in people with shoulder osteoarthritis. It’s early research, so the goal is mainly to see if the treatment is safe and possibly helpful.
Stanford, CaliforniaAges 25–75 - NCT04933149Enrolling by invitationPhase 4
Ketamine infusion for nerve pain after shoulder nerve injuries
This trial tests whether a ketamine infusion can reduce nerve-related pain after traumatic brachial plexus (shoulder/arm nerve) injuries. It specifically targets people with pain caused by nerve damage who are scheduled for surgery to repair the nerve.
Rochester, MinnesotaAges 18 years+ - NCT04995224Recruiting
Study what causes long-term pain in new Crohn’s or colitis
This study looks at why some people develop long-term pain after being newly diagnosed with ulcerative colitis or Crohn’s disease. It may help researchers understand the pain process and improve future treatments.
LondonAges 18 years+ - NCT04992624RecruitingPhase 2
Cannabinoid treatment effects on knee pain and nerve signals
This Phase 2 study tests whether a cannabinoid-related treatment changes how pain works in people with knee osteoarthritis. It uses questionnaires, MRI, and gentle nerve testing to understand if treatment helps pain and pain-related signals.
Ann Arbor, MichiganAges 21–75 - NCT04918329Recruiting
Digestive symptom check-in study for adults
This study follows adults with long-lasting “functional” digestive symptoms as part of routine care. It may help researchers better understand these conditions and improve how they are managed.
RouenAges 18 years+ - NCT04867187Recruiting
Brain stimulation plus mirror therapy for nerve pain
This trial tests whether a noninvasive brain stimulation treatment (repeated TMS) combined with mirror therapy can reduce nerve pain. It may help people whose nerve pain has lasted for months and hasn’t improved enough with usual medicines.
BronAges 18–85 - NCT04909138Recruiting
Intermittent nerve stimulation instead of daily low-frequency therapy
This study tests whether switching from continuous implanted nerve stimulation to an intermittent schedule can keep pain relief for people with chronic back and/or leg pain. You would be compared in a structured study plan to see if the alternate dosing works for you and is safe.
Chicago, IllinoisAges 18–90 - NCT04864080Recruiting
Online study to measure brain-related signals in pain or depression
This trial uses an online study platform to look for “cognitive biomarkers,” which are measurable patterns in thinking or brain-related responses. It compares people with pain or depression to healthy controls to see how these patterns differ and could help future research or care.
Minneapolis, MinnesotaAges 18 years+ - NCT04894864RecruitingPhase 4
Opioid-free anesthesia for elective abdominal aortic aneurysm surgery
This trial studies an “opioid-free” anesthesia and pain plan during planned open surgery for an abdominal aortic aneurysm. The goal is to see whether this approach reduces surgical stress and pain compared with usual care.
Heraklion, CreteAges 40–85 - NCT03756961Recruiting
Opioid-free care plan for people having weight-loss surgery
This trial studies whether an opioid-free or opioid-sparing care pathway can improve comfort and outcomes for adults undergoing laparoscopic weight-loss surgery. It may help people avoid side effects from opioid pain medicines while still managing pain safely.
Lindesberg, Region ÖrebroAges 18 years+ - NCT03876054Recruiting
Tracking outcomes after Abbott neurostimulator implantation
This study follows people long-term after they get an Abbott device implanted to help with chronic pain. It aims to learn how well the therapy works in real-world care over time.
Phoenix, ArizonaAges 18 years+ - NCT04708808Recruiting
Music therapy during ultrasound-guided abortion procedure
This trial tests whether listening to music during an ultrasound-guided vacuum aspiration procedure can help make the procedure more comfortable or less stressful. It focuses on people having first-trimester pregnancy termination under local anesthesia.
Hong Kong, ShatinAges 18 years+ - NCT04733599Recruiting
Spinal cord stimulation for long-term arm nerve pain
This trial tests whether a high-frequency spinal cord stimulator can reduce long-term nerve pain in the arm after a brachial plexus injury. It may help people whose pain has lasted at least 3 months despite standard treatments.
Jacksonville, FloridaAges 18 years+ - NCT04734106RecruitingEarly Phase 1
Aloe vera for bladder pain and frequent urination
This early-stage study tests whether aloe vera can reduce symptoms of interstitial cystitis, such as bladder pain and frequent urination. You’d help researchers check both safety and symptom relief.
Winston-Salem, North CarolinaAges 18–80 - NCT04730700Recruiting
Radiofrequency treatment test for facet back pain
This study compares a nerve procedure (radiofrequency “neurotomy” using an expandable electrode) to non-procedure medical care for long-lasting low back pain from facet joints. It aims to see whether the procedure helps more safely than conservative treatment.
Kansas City, KansasAges 18 years+ - NCT04693377Recruiting
Freezing tumor treatment plus targeted radiation for painful bone spread
This study tests whether combining a “freezing” procedure (cryoablation) with focused external radiation (SBRT) can reduce pain from bone metastases. It’s for people with certain cancers that have spread to bone and are having significant pain in a specific bone spot.
Houston, TexasAges 18 years+ - NCT04679844Recruiting
Test bone putty for back fusion versus bone graft alternatives
This study compares a ready-to-use bone putty to standard bone graft materials (with or without your own bone) during back fusion surgery for unstable lower back problems. It looks at whether the putty works as well or better to help the bones fuse and heal.
Irvine, CaliforniaAges 18 years+ - NCT04605445Recruiting
One vs two dentist visits for infected root canals
This study compares whether treating an infected, dead tooth in one visit works as well as using two visits. It may help you and your dentist choose the simplest schedule while still clearing infection and supporting healing.
Vaxjo, Kronoberg CountyAges 18 years+ - NCT04653064Recruiting
Brain imaging study of how people feel heat and pain
This study uses MRI scans to understand how your brain responds to different feelings, including mild heat pain. It may help researchers learn more about pain and brain processing by comparing your responses during the tests.
Hanover, New HampshireAges 18 years+ - NCT04576078RecruitingPhase 2
Nefopam for less pain after knee replacement surgery
This Phase 2 study tests whether oral nefopam can reduce pain after total knee replacement done with spinal anesthesia. It looks at whether this medicine works better than the usual post-surgery pain plan and how safely it can be used.
Lyon, LyonAges 18–75 - NCT04526093Recruiting
Study of medical cannabis using patient symptom reports
This study looks at how medical cannabis affects symptoms like pain, epilepsy, sleep, and anxiety or depression, based on what patients report over time. It may help researchers understand what works in real life when people use verified medical cannabis products.
Toronto, OntarioAges 19 years+ - NCT04577690RecruitingPhase 4
PECS pain study for children getting a chest device implanted
This trial tests a pain-control method (PECS) during surgery for children who are having a small chest device implanted. It may help reduce discomfort during and after the operation.
Toronto, OntarioAges 3–18 - NCT04425395Recruiting
Sounds without words may change pain tolerance
This study looks at whether nonverbal vocal sounds (like certain tones or sounds) change how much pain you can tolerate. You might be asked to listen to or produce sounds while your pain response is measured.
Saint-EtienneAges 18–60 - NCT04457895Recruiting
Yoga and physical therapy program for hormone therapy breast cancer pain
This trial studies whether a combined physical therapy, yoga, and patient education program can reduce pain in people with non-metastatic breast cancer who are taking hormone therapy. It may help with pain and day-to-day comfort while you continue hormone treatment.
Libourne, AquitaineAges 18–99
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,136 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.