Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,136 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05640232RecruitingPhase 3
Test medicine CDE100 for severe menstrual cramp pain
This Phase 3 study tests whether CDE100 can reduce menstrual cramp pain in people with primary dysmenorrhea (cramps that are not caused by another medical condition). It also checks how safe the treatment is and how it’s tolerated over time.
Hortolândia, São PauloAges 16–35 - NCT05658575RecruitingPhase 2/Phase 3
Tablets to treat sudden gout flare pain
This trial studies dapansutrile tablets (OLT1177) to see how well they work for people in the first 4 days of an acute gout flare. It may help reduce pain and inflammation in the specific joint where your gout is flaring.
Birmingham, AlabamaAges 18 years+ - NCT05661903RecruitingPhase 2
Spinal cord stimulator study for nerve pain and brain effects
This Phase 2 study looks at how spinal cord (or nerve-root) stimulation affects pain signals in the brain and body. You may qualify if you already have a stimulator set to a comfort mode that avoids “tingling” sensations.
Boston, MassachusettsAges 18–80 - NCT05657964Recruiting
Study of a back pain exercise program for chronic low back pain
This trial tests whether a structured exercise/education program can help people with chronic lower back pain. You may qualify if your pain and disability scores are high enough and you can complete study activities in English.
Redwood City, CaliforniaAges 18–65 - NCT05635929Recruiting
Topical treatment to reduce mouth sores during or after radiation
This study tests a new cream/gel applied to the mouth to lower the chance of severe mouth sores in people receiving radiation for head and neck cancer. It also looks at how treatment affects quality of life using patient questionnaires.
Madrid, MadridAges 18 years+ - NCT05618392Recruiting
Pain check after feeding tube placement
This trial studies how much pain people feel after a radiology-guided feeding tube is placed through the skin while you’re awake with local numbing medicine. It also looks at factors that might help predict pain, to improve comfort for future patients.
ValenceAges 18 years+ - NCT05636137Enrolling by invitation
Study links internet habits with pain and body awareness
This study asks high school students about internet use, musculoskeletal pain (pain in muscles and bones), and body awareness (how well you notice your body). It aims to understand whether these things are connected and may help guide future supports for teens.
Muğla, MenteşeAges 15–18 - NCT05596591Recruiting
Shockwave treatment for knee arthritis pain with MRI-confirmed lesions
This trial tests whether focused shockwave therapy (a non-surgical treatment) can reduce knee arthritis pain. It specifically targets people whose MRI shows a small bone problem in one area of the knee.
Cedar Knolls, New JerseyAges 30–80 - NCT05602636RecruitingPhase 4
Nerve-block pain options during forearm surgery
This trial compares three ways to control pain during forearm surgery: different nerve blocks versus using a PCA pain pump. It may help find the approach that gives better pain relief and comfort after surgery, especially for longer procedures.
DamiettaAges 18–70 - NCT05592132Recruiting
Virtual reality to help children handle cancer treatment pain
This trial studies whether virtual reality can reduce pain and discomfort during painful medical procedures for children getting care for benign (non-cancerous) tumors or cancer. It may help make treatments feel easier for you and your child during procedures.
Saint-DenisAges 6–18 - NCT05556902Recruiting
Testing how epidural spinal cord stimulation may help chronic pain
This study looks at how a device that sends mild signals to the area around your spinal cord may work for long-lasting (chronic) pain. You may be asked to visit a research lab, have blood taken, and follow the study plan so researchers can understand the treatment’s effects.
Birmingham, AlabamaAges 18–89 - NCT05555485Recruiting
Check if ear stimulation can help chronic pain and reduce opioids
This study tests whether a device that stimulates the ear (through the skin) can reduce chronic pain and help people lower their opioid pain medicine. It may help you manage pain with less opioid use if you meet their safety and medication criteria.
Galveston, TexasAges 18–65 - NCT05585788Recruiting
Opioid pain device test for cancer surgery patients
This study tests a device that helps you safely use opioid (strong pain) medicine after major cancer surgery. It may help improve post-surgery pain control while tracking how people use the medicine.
New York, New YorkAges 18–99 - NCT05508360Recruiting
Testing an artificial spacer implant for one-level low back pain
This study tests whether inserting a small artificial implant into a single painful disc can reduce long-term low back pain and disability. It’s for people who tried non-surgical treatments for at least 6 months but still have significant symptoms from degenerative disc disease.
Medellín, AntioquiaAges 22 years+ - NCT05543785Recruiting
Ketorolac pain block for lower-limb surgery with a tourniquet
This trial looks at whether a ketorolac pain medicine given directly to the leg during surgery can reduce pain after lower-limb orthopedic operations. It may help people who are having one leg operated on with spinal anesthesia and a tourniquet, but it has several safety limits.
Al MansurahAges 19–60 - NCT05532865Recruiting
Biobank study for adults with systemic sclerosis
This study follows adults with systemic sclerosis who are being seen at a specific hospital and asks for consent to store blood and other samples for future research. It may help researchers better understand the disease and develop better tests or treatments over time.
BrestAges 18 years+ - NCT05543694RecruitingPhase 4
Testing epidural pain relief for labor
This study is testing how well a combination of two medicines (bupivacaine and lidocaine) works for epidural pain relief during early labor. The goal is to find the best dose to help manage labor pain.
Boston, MassachusettsAges 18–50 - NCT00389142Recruiting
Find genes linked to bladder pain and urinary symptoms
This study looks for genetic (inherited) causes of bladder pain syndrome (IC/BPS), using information from people who have typical urinary symptoms. It may help doctors understand why IC/BPS happens, which could guide better future care.
Boston, MassachusettsAges 1 year+ - NCT05494684Recruiting
Nature-based relaxation for children during blood tests
This study tests whether a nature-based activity can help children aged 5 to 9 feel calmer and less stressed during a blood draw. It aims to make the experience more comfortable for children with long-term illnesses.
OuluAges 5–9 - NCT04938245Recruiting
Testing improvements to spinal cord stimulation with ECAPS
This study looks at a method (ECAPS) to improve how spinal cord stimulation works. It may help people who are already scheduled to have a spinal cord stimulator trial started.
Minneapolis, MinnesotaAges 22 years+ - NCT05459402RecruitingPhase 2/Phase 3
Methadone dose testing for opioid use disorder pain relief
This study compares taking methadone as one dose versus split into two doses to see which approach works better for people who have pain. It’s meant for adults already on a steady methadone program and who can follow study visits and procedures.
Baltimore, MarylandAges 18–100 - NCT05421416RecruitingPhase 2
Loratadine to prevent bone pain after stem cell transplant treatment
This trial tests loratadine (an allergy medicine) to see if it can prevent bone pain caused by a growth-factor injection used during lymphoma or multiple myeloma treatment. It may help reduce pain around the time you get that injection and your upcoming stem cell transplant.
Edmonton, AlbertaAges 18 years+ - NCT05444361Enrolling by invitation
Ultrasound freezing treatment for pain after mastectomy
This trial tests a “freezing” nerve procedure guided by ultrasound to help reduce pain after mastectomy. It aims to lessen postoperative pain by temporarily calming specific nerves involved in chest wall sensation.
Los Angeles, CaliforniaAges 18 years+ - NCT05437575RecruitingPhase 3
Testing pain medicine given before arrival to a trauma center
This study tests whether giving pain medicine soon after an injury (before you reach the trauma center) improves comfort and care. You might be eligible if you’re transported to a participating trauma center and meet specific shock and pain levels.
San Diego, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,136 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.