Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,136 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06171659Recruiting
PET/MRI scan to find pain sources after joint surgery
This study uses a special type of scan called PET/MRI to look for areas in the body that may be causing ongoing pain after joint replacement or arthroscopy. It aims to better understand why some people have pain that lasts months after surgery.
Madison, WisconsinAges 18–85 - NCT06149819Recruiting
Chest pain nurse track for emergency care
This trial is testing a nurse-led care pathway for people who come to the emergency room with chest pain that is not caused by an injury. The goal is to see if this approach can improve care and speed up the process.
Grenoble, GrenobleAges 18 years+ - NCT06141720Recruiting
Mindfulness for endometriosis surgery
This trial tests if a mindfulness program can help people preparing for endometriosis surgery. It may reduce stress and improve recovery.
Hershey, PennsylvaniaAges 18 years+ - NCT06133933Enrolling by invitation
Shoulder replacement and pain medication study
This study looks at how your pain tolerance before a total shoulder replacement might relate to how much pain medication you need after surgery. The goal is to help doctors better manage pain medication after surgery.
Camden, New JerseyAges 18 years+ - NCT06106191Recruiting
Mindfulness program for chronic low back pain
This trial tests a mindfulness-based program designed to help people with long-term low back pain. It aims to see if combining mindfulness with a personalized approach can improve pain management and daily functioning.
Boston, MassachusettsAges 18 years+ - NCT06119698Recruiting
Improving Health for Older Adults With Pain Through Engagement
This study tests a program to help older adults with long-lasting bone, joint, or muscle pain become more active. Participants wear a smartwatch and get support to manage their pain and improve their health.
Boston, MassachusettsAges 55 years+ - NCT06113211RecruitingPhase 4
Non-opioid pain control after fracture surgery
This trial tests a combination of non-opioid medications to manage pain after surgery for a broken bone, aiming to reduce or avoid the use of opioids. It may help you control pain without the risks of strong painkillers.
Detroit, MichiganAges 18–80 - NCT05700279Recruiting
PTSD treatment to help prevent future chronic pain
This study tests whether treating post-traumatic stress disorder (PTSD) right when you come to the emergency room for new, acute pain can lower the chance you develop long-term (chronic) pain. It may help people whose pain and trauma symptoms start around the same time.
Chicago, IllinoisAges 18–70 - NCT06094257Recruiting
Study on sensation and satisfaction after mastectomy
This study looks at how people feel after mastectomy, including transgender patients and those having nipple-sparing surgery. It aims to understand sensation and satisfaction to improve future care.
Boston, MassachusettsAges 18 years+ - NCT06101303Recruiting
Endometriosis pain study using surgery and surveys
This study looks at pain in people with or without endometriosis who are having laparoscopic surgery. Researchers want to understand more about pelvic pain by collecting information before, during, and after surgery.
St Louis, MissouriAges 12–45 - NCT06038240Recruiting
Pain self-management program for knee replacement
This study is testing a program to help people manage pain on their own before and after total knee replacement surgery. It aims to improve recovery and reduce reliance on pain medications.
Charlottesville, VirginiaAges 18–85 - NCT06027099RecruitingPhase 3
Testing tizanidine to help reduce opioids after surgery
This study tests whether adding a low-dose muscle relaxant (tizanidine) to your pain plan after surgery can help you safely lower your opioid use. It's for people who have been on long-term opioids and are having surgery at specific hospitals.
Stanford, CaliforniaAges 18–75 - NCT06019793Enrolling by invitation
Recording brain signals during deep brain stimulation for pain
This study tests whether recording brain activity during deep brain stimulation (DBS) for chronic pain can help improve future treatments. It is for people with long-lasting, severe pain that hasn't been helped by other treatments.
Phoenix, ArizonaAges 22 years+ - NCT06023225Recruiting
Sex hormones, pain, and opioid use in girls after surgery
This study looks at how sex hormones affect pain and the use of pain medicine after orthopedic surgery in girls. It might help explain why some people need more pain relief than others.
St Louis, MissouriAges 11–16 - NCT05986292RecruitingPhase 2
Study of new pain treatments for chronic pain
This study tests new treatments for people with chronic pain that has lasted at least 12 weeks. It aims to find better ways to reduce pain and improve quality of life.
Birmingham, AlabamaAges 18 years+ - NCT06001749RecruitingPhase 2
Psilocybin for cancer pain study
This trial tests whether psilocybin (a psychedelic drug) can help with severe cancer pain. You may qualify if your pain is high despite strong medications and you are willing to be monitored closely.
Boston, MassachusettsAges 18 years+ - NCT05963607Recruiting
Weighted blanket trial to reduce chronic pain
This study tests whether using a 15-pound weighted blanket can lower pain and improve sleep for Veterans with long-lasting, non-cancer musculoskeletal pain. It may help by reducing discomfort during rest and sleep.
San Diego, CaliforniaAges 18 years+ - NCT05961800Recruiting
Study ways to evaluate lumbar back pain blocks
This study looks at how well different methods can evaluate a common procedure used for chronic low back pain (lumbar medial branch blocks). If you have long-lasting, everyday back pain and are having this procedure, you may help researchers compare evaluation approaches.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05961501Enrolling by invitationPhase 2/Phase 3
CBD and CBN for long-lasting facial pain and muscle headaches
This trial tests whether CBD and CBN can reduce facial pain and headaches caused by muscle-related problems that have lasted more than 3 months. It may help people who have ongoing symptoms find a new treatment option.
WroclawAges 18 years+ - NCT05146778Recruiting
Opioid-free anesthesia to reduce long-term post-mastectomy pain
This study tests whether a pain-control approach without opioids (strong pain medicines) can lower persistent pain after mastectomy. It may help people avoid long-term pain and opioid side effects.
SeoulAges 19–80 - NCT05909709RecruitingPhase 1
Tested injections for chronic facet-related back pain
This Phase 1 study tests the safety of an injection called Alocyte in adults with long-lasting back pain coming from the facet joints. If you qualify, you may be followed closely to check side effects and how you respond over multiple visits.
North Miami, FloridaAges 18 years+ - NCT05851196Recruiting
Personalized exercise for recurrent low back pain
This study looks at how back muscle features can help tailor an exercise program for people with recurring, non-specific low back pain. It may help by matching exercises to your specific back function and symptoms.
DiepenbeekAges 18–60 - NCT05716321Recruiting
Study of pain and function after limb amputation surgery
This study looks at pain and day-to-day functioning after someone has a limb removed due to surgery. The results may help doctors better understand what to expect and how to improve comfort and mobility after amputation.
Hershey, PennsylvaniaAges 18–89 - NCT05721027RecruitingPhase 4
Ibuprofen alone or with a steroid for new sciatica pain
This trial compares ibuprofen alone versus ibuprofen plus dexamethasone (a steroid) for short-term relief of acute nerve-related low back pain that shoots into the buttock or leg. It aims to see which approach reduces pain and improves function after an emergency visit.
The Bronx, New YorkAges 18–70
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,136 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.