Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07706348RecruitingPhase 1/Phase 2
Pain relief with ondansetron and lidocaine after abdominal cancer surgery
This trial tests if rinsing the belly with ondansetron (a nausea medicine) and lidocaine (a numbing medicine) during surgery can reduce pain afterward. It is for people having major lower abdominal cancer surgery who are otherwise healthy.
AsyutAges 20–70 - NCT03184545RecruitingPhase 3
Electrical stimulation vs physical therapy for knee pain
This trial compares an electrical stimulation treatment to standard physical therapy for people with long-lasting pain in the front of the knee. It aims to see which approach better improves symptoms and function for patellofemoral pain syndrome.
New York, New YorkAges 18–40 - NCT03489499Recruiting
Genetic testing study of pain after planned surgery
This study looks at whether genetic differences can help predict how much pain you may have after an elective (planned) operation. If you qualify, you may be asked to give consent and share information so researchers can compare pain experiences across people.
BernAges 18 years+ - NCT03612193Recruiting
Study how gut bacteria relates to complex regional pain
This study looks at differences in gut bacteria (from a stool sample) in people with complex regional pain syndrome (CRPS) and in people who live with them. The goal is to understand whether gut microbes might play a role in CRPS and improve understanding of the condition.
St Louis, MissouriAges 18 years+ - NCT03695887RecruitingEarly Phase 1
Disposable nitrous oxide for pain during burn dressing changes
This early-stage study tests whether using disposable nitrous oxide canisters can better control pain when you need burn dressing changes. It may help by making dressing changes more comfortable, but eligibility depends on your burn size, health, and breathing ability.
Winnipeg, ManitobaAges 18 years+ - NCT03737292RecruitingPhase 4
Numbing medicine for chest surgery pain after small lung operations
This trial tests whether a long-lasting numbing shot (liposomal bupivacaine) works better than a regular numbing shot (plain bupivacaine) for pain after minimally invasive chest surgery. It may help you have less post-surgery pain and potentially use less pain medication.
Hershey, PennsylvaniaAges 18 years+ - NCT03794466Recruiting
Study pain relief after blocking gonadal veins for pelvic congestion
This study looks at how much pelvic pain improves after a procedure called gonadal vein embolization (blocking problem veins). It mainly applies to people diagnosed with pelvic congestion syndrome caused by venous (vein) problems, treated during a specific time window.
Kansas City, KansasAges 18 years+ - NCT03823534RecruitingPhase 3
Study pain control after preventive femur bone surgery
This Phase 3 study tests a pain medicine plan used after preventive surgery to place a metal rod inside the thigh bone (femur) before a fracture happens. The goal is to find an approach that controls post-surgery pain while being safe for the right patients.
St Louis, MissouriAges 18 years+ - NCT03836248Recruiting
Osteopathic care added to standard treatment for chronic low back pain
This study tests whether adding osteopathic treatment to usual medical care can improve chronic low back pain. It focuses on people whose back pain has no clear structural cause and has lasted more than 3 months.
ToulouseAges 18–64 - NCT03852381Recruiting
Spinal cord stimulation for nerve pain after back surgery
This study looks at how spinal cord stimulation (a device that sends mild signals to the spinal cord) affects nerve pain after lumbar surgery. It also aims to help predict who is most likely to improve and why, comparing patients with and without certain sensory symptoms.
Toronto, OntarioAges 18–80 - NCT03858205Recruiting
Low-dose radiation to relieve pain from bone tumors
This trial studies whether low-dose radiation can reduce pain from a specific bone lesion caused by multiple myeloma. It may help people whose main problem is painful bone metastasis, with targeted treatment to the painful spot.
Duarte, CaliforniaAges 18 years+ - NCT03862365Recruiting
Study genetics in people with nerve pain
This study looks at genetic differences in people being checked for a common type of nerve problem called distal symmetric polyneuropathy (nerve damage that usually affects the hands and feet). By understanding genetics, researchers hope to learn more about why neuropathic (nerve) pain happens and how it may differ between people.
BergenAges 18–70 - NCT03877653Recruiting
Freedom-1 treatment for long-term knee pain in adults
This study tests a procedure called Freedom-1 to reduce long-term, limiting knee pain from knee arthritis. It may help if other non-surgical options didn’t work and you meet specific knee and health requirements.
Placentia, CaliforniaAges 18 years+ - NCT03906422Recruiting
Study of pain after placing braces archwire
This study compares how much pain people feel after their braces archwire is first put in. It may help orthodontists choose approaches that make the early pain experience easier.
Aurora, ColoradoAges 12 years+ - NCT03984565RecruitingPhase 2
Study of a new cannabinoid for long-term body pain
This Phase 2 study tests how a new cannabinoid product affects people with ongoing musculoskeletal pain (like arthritis or injuries). It’s meant to see whether the product can improve pain for eligible adults who are not already using CBD regularly.
Belmont, MassachusettsAges 21 years+ - NCT07703293Recruiting
Testing nerve branches for chronic knee pain relief
This study tests a procedure targeting specific nerve branches in the thigh to treat long-lasting knee pain from osteoarthritis. It may help people who haven't found relief from standard treatments like pain relievers or physical therapy.
AnkaraAges 45–80 - NCT04059172RecruitingEarly Phase 1
Ibuprofen plus acetaminophen for braces pain
This early study compares braces pain relief using: ibuprofen alone, ibuprofen plus acetaminophen together, or placebo (no active pain medicine). It may help find which approach works best and is safest for people starting orthodontic treatment.
Aurora, ColoradoAges 12–80 - NCT04074798Recruiting
Breathing over fast and slow movements for back pain
This study tests how breathing changes (hyperventilation) might affect people with long-lasting low back pain. It may help researchers understand triggers or symptoms, and compare them to people who do not have back pain.
HasseltAges 20–60 - NCT04102566RecruitingPhase 4
Better pain control during TURP surgery
This trial tests whether a pain-control approach can make TURP (prostate surgery through the urine tube) more comfortable. It may help you manage pain with the study medicines during and after your procedure.
Seattle, WashingtonAges 18 years+ - NCT04109638Recruiting
PEMF therapy to reduce pain after shoulder or knee surgery
This trial studies whether PEMF, a type of non-surgical device that uses pulsed electromagnetic fields, can reduce pain after shoulder or knee surgery. If you join, you’ll also be expected to do post-surgery physical therapy exercises and report your pain and function.
Redwood City, CaliforniaAges 18 years+ - NCT04130464RecruitingPhase 4
Analgesic placed inside the belly for after-surgery pain
This study tests whether placing a pain medicine inside the abdomen during hysterectomy can reduce postoperative pain. It targets people having specific types of minimally invasive hysterectomy for non-cancer reasons.
Washington D.C., District of ColumbiaAges 18–65 - NCT04134702Recruiting
Acupuncture for less pain after outpatient knee surgery
This study tests whether acupuncture can reduce pain after outpatient arthroscopic knee surgery done under general anesthesia. It may help by improving pain control while avoiding certain medicine side effects, but you must meet several specific safety and medication limits.
Greifswald, VorpommernAges 19–55 - NCT04164225Recruiting
Testing how qigong affects brain activity in chronic low back pain
This study looks at how doing qigong may change brain activity and physical symptoms in adults with long-lasting low back pain. It’s mainly to see whether the brain and symptom measures can be identified and tracked after qigong practice.
Minneapolis, MinnesotaAges 18–70 - NCT04166877RecruitingPhase 4
Magnesium drip to reduce pain in ICU trauma patients
This trial tests whether a magnesium infusion can better control pain in adults who have serious injuries and need intensive care. It compares magnesium as part of pain treatment to standard pain care to see if pain improves and stays controlled.
Sacramento, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.