Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06414356RecruitingPhase 4
Ketamine for nerve pain and PTSD in military personnel
This study tests whether ketamine infusions can help with ongoing nerve pain and PTSD symptoms. It's for active-duty service members, veterans, and retirees who have had moderate nerve pain for at least 3 months.
San Antonio, TexasAges 18–70 - NCT06415240Recruiting
Comforting Touches for Newborn Pain in the NICU
This study tests whether gentle touch or wrapping your baby cozily (facilitated tucking) can reduce pain during a first-time arterial blood draw in the NICU. It may help find simple ways to comfort newborns during procedures.
IslamabadAges 1 day–4 weeks - NCT06419439RecruitingPhase 2
Ketamine for Veterans with Chronic Back Pain and Depression
This study tests whether ketamine, combined with talk therapy, can help veterans with both chronic low back pain and depression. The goal is to reduce pain and improve mood.
Ann Arbor, MichiganAges 18 years+ - NCT06420141Recruiting
Nerve pain after ankle fracture surgery
This study looks at why some people develop nerve pain (neuropathic pain) after breaking their ankle and having surgery. If you have an ankle fracture that needs surgery, you may be able to join and help researchers understand this type of pain better.
Indianapolis, IndianaAges 18–85 - NCT06421350Recruiting
Closed-loop spinal cord stimulation for complex regional pain syndrome
This trial tests a new type of spinal cord stimulator that automatically adjusts to your pain signals. It may help people with complex regional pain syndrome (CRPS) who have not tried this kind of therapy before.
La Jolla, CaliforniaAges 18 years+ - NCT06426875Recruiting
Isometric training for shoulder pain in bowlers
This trial tests if isometric muscle training (holding still muscle contractions) can reduce shoulder pain and improve function and bowling performance in male bowlers. It may help if your pain affects your game and causes emotional distress.
Rawalpindi, Punjab ProvinceAges 18–30 - NCT06436378Recruiting
Music Therapy for Chronic Pain Patients
This study tests whether listening to music can help people with chronic pain feel better. It is for people who are already being treated at the pain clinic at CHU de Québec-Université Laval and can attend a few sessions at the university.
Québec, QuebecAges 18 years+ - NCT06442566RecruitingPhase 1/Phase 2
Enhancing opioid therapy for chronic pain with buprenorphine, counseling, and brain stimulation
This study is testing whether adding a medication (buprenorphine), counseling, and a type of brain stimulation (TMS) can improve long-term opioid therapy for chronic pain. If you have been taking prescription opioids daily for at least 3 months and have extra risk factors for opioid-related problems, this trial may offer you new ways to manage pain and reduce risks.
Charleston, South CarolinaAges 18 years+ - NCT06446596Recruiting
Phone-based exercise coach vs. standard home exercises for low back pain
This study compares doing exercises at home with a video coach on your phone versus doing standard exercises you get from a doctor. The goal is to see if the video program helps people with low back pain more than regular home exercises.
Valencia, Select OneAges 18–65 - NCT06450483Recruiting
Acupuncture for neck pain in college athletes
This study tests whether a type of acupuncture (called auricular vagus nerve stimulation, or AVNS) can help college athletes with neck pain. It looks at how the treatment affects pain, balance, and heart rate. If you’re a healthy college athlete with mild to moderate neck pain and no recent injuries, you may be a good fit.
Sharjah cityAges 18–26 - NCT06452030Recruiting
Testing a new exercise for trunk muscles in low back pain
This study is testing a special training program for the muscles that support your spine. It is for people who have had frequent but mild episodes of low back pain that have recently calmed down. The goal is to see if changing how these muscles work can prevent future pain.
GhentAges 18–65 - NCT06452615Recruiting
Shock wave therapy for nerve pain after mastectomy
This study tests if a treatment called extracorporeal shock wave therapy (using sound waves from outside the body) can help relieve nerve pain that some women have after a mastectomy. It may be an option if you have burning, tingling, or numbness in your chest, armpit, or upper arm that started after your surgery.
CairoAges 40–65 - NCT06456268Recruiting
VibraCool to reduce pain and opioid use after ACL surgery
This trial tests a device called VibraCool to see if it can reduce pain and the need for opioid painkillers after ACL reconstruction surgery.
New York, New YorkAges Any age - NCT06457828Recruiting
Root canal methods for painful molars: open tip vs steroid
This trial is testing two methods during a root canal on a painful molar: one that keeps the tip of the root open and one that uses a steroid medicine inside the tooth. The goal is to see which approach causes less pain afterward.
IsmailiaAges 21–60 - NCT06467409RecruitingPhase 2
Study of LPM3480392 for pain after knee surgery
This trial tests an injection called LPM3480392 to see if it safely reduces moderate to severe pain after knee replacement or ligament repair surgery. It aims to help people who need strong pain relief after this type of surgery.
WuhanAges 18 years+ - NCT06469632Recruiting
Radiofrequency for pelvic pain after first vaginal birth
This trial tests whether a non-surgical treatment called radiofrequency can help relieve pelvic pain that starts after a first vaginal birth. The study focuses on a type of muscle pain called myofascial pain syndrome.
Alcalá de Henares, MadridAges 18–45 - NCT06471348Recruiting
Pain control after scoliosis surgery: comparing two numbing medicines
This study compares two types of numbing medicine used during scoliosis surgery to see which provides better pain relief after the operation. One is a long-acting version (liposomal bupivacaine) and the other is a standard short-acting mix (bupivacaine with epinephrine). If you are a teen having surgery for Adolescent Idiopathic Scoliosis, this trial may help find a way to reduce pain and possibly lessen the need for opioids afterward.
Boston, MassachusettsAges 10–17 - NCT06472622RecruitingEarly Phase 1
Brain imaging study of pain and effort
This study uses brain scans to understand how people experience pain and effort. It compares healthy volunteers to people with ME/CFS to see if there are differences in brain activity.
Bethesda, MarylandAges 18–50 - NCT06473389Recruiting
A treatment for shoulder pain after stroke
This trial tests a treatment called suprascapular radiofrequency ablation (a targeted heat procedure) to help relieve shoulder pain after a stroke. It is for people who have had a stroke at least 3 months ago and still have severe shoulder pain.
Ankara, YenimahalleAges 18 years+ - NCT06477965Recruiting
Registry for artery embolization to treat chronic pain
This is a registry study that gathers information from people who have had an artery embolization procedure to treat long-term pain from conditions such as arthritis. The goal is to track outcomes and better understand the procedure's effectiveness.
Cary, North CarolinaAges 18 years+ - NCT06480175Recruiting
Neck Pain Relief: Radiofrequency Plus Nerve Block
This study tests whether a procedure that uses radiofrequency (a type of heat) plus a nerve block can reduce neck pain from arthritic joints in the spine. It is for people who have not gotten enough relief from other treatments.
CairoAges 30–70 - NCT06483035Recruiting
Treating phantom limb pain with visual simulation therapy
This study tests a computer-based therapy that uses visual exercises to help reduce phantom limb pain after amputation. If you have chronic pain in a missing limb, this treatment might offer relief without medication.
OsloAges 18 years+ - NCT07693634Recruiting
Online rehab for knee pain in active adults
This study tests a home-based tele-rehabilitation program for people with front knee pain (patellofemoral pain syndrome) who are recreational athletes. It aims to see if online guided exercises can reduce pain and improve function.
Faisalābad, PunjanAges 18–35 - NCT07691840Recruiting
Intrathecal therapy vs. standard care for severe cancer pain
This trial compares a treatment that delivers pain medicine directly to the spinal cord (intrathecal therapy) with usual pain control. It is for people with severe cancer pain that is not helped by oral or intravenous opioids.
JetteAges 18 years+
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.