Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07377370Recruiting
Pain after gum graft surgery study
This study looks at factors that affect pain after a gum graft procedure. If you need gum surgery to cover exposed tooth roots or add gum tissue, you may be able to join.
Barcelona, Sant Cugat Del VallesAges 18 years+ - NCT07382297Recruiting
Knee tumor pain study with extra nerve block
This study tests if adding an ultrasound-guided nerve block (IPACK) behind the knee to a standard nerve block (adductor canal block) can better control pain after knee tumor surgery. If you are having knee tumor removal and are in fair to poor health, this may help improve your recovery.
CairoAges 18–65 - NCT07383558Recruiting
Adding nerve treatment for chronic heel pain
This trial tests if adding a nerve treatment (pulsed radiofrequency of the sural nerve) to standard care helps people with long-lasting heel pain. It may reduce pain and improve function.
AnkaraAges 18–65 - NCT07386353RecruitingPhase 4
Comparing two ways to give pain medicine after C-section
This trial tests two different ways of giving morphine for pain relief after a planned cesarean section: one is injected into the spinal fluid and the other into the space around the spinal cord. The goal is to see which method works better and is safer.
Funchal, MadeiraAges 18 years+ - NCT07391930Recruiting
High intensity exercise for period pain
This study tests if high-intensity interval training (short bursts of intense exercise) can help reduce period pain. It is for people who have not given birth and experience regular period pain.
Alcalá de Henares, MadridAges 18–40 - NCT07392099Recruiting
Comparing a single pain relief class vs. usual care after orthopedic surgery
This study tests whether a single, 1-hour class on pain management (called Empowered Relief) can help people recover better after orthopedic surgery (like hip or knee replacement) compared to usual care. It is for people who have had moderate to severe pain for at least 3 months and are fluent in French.
Sherbrooke, QuebecAges 18 years+ - NCT07394673Recruiting
Nerve block for pain after shoulder surgery
This trial tests a new ultrasound-guided nerve block for pain relief after shoulder surgery. It aims to improve comfort and reduce the need for pain medications.
BursaAges 18–65 - NCT07395934Recruiting
Comparing two epidural methods for labor pain relief
This study compares two ways of giving epidural pain relief during labor: a programmed intermittent bolus (PIEB) versus a continuous infusion (CEI). The goal is to see which method works better for managing pain in vaginal delivery.
Da NangAges 18–40 - NCT07396233Recruiting
Knee Osteoarthritis Therapy: Diagonal Movement Patterns
This trial tests a type of physical therapy called proprioceptive neuromuscular facilitation for people with knee osteoarthritis. It may help reduce pain and improve how well your knee works.
Karachi, SindhAges 40–60 - NCT07396545Recruiting
Comparing two types of nerve blocks for pain after stomach cancer surgery
This trial looks at two different pain-blocking injections (nerve blocks) to see which one works better for pain after keyhole stomach cancer surgery. If you are having this type of surgery, joining could help us learn which block gives you better pain relief.
Yinchuan, NingxiaAges 18 years+ - NCT07396753Recruiting
Nerve block to reduce opioid use after kidney donor surgery
This study tests a nerve block called Transversalis Fascia Plane Block to see if it lowers the amount of strong pain medicine (opioids) needed after a kidney donor surgery. It may help you have less pain and fewer side effects.
Istanbul, ZeytinburnuAges 18–80 - NCT00515060Recruiting
Study pain testing in cancer patients and healthy volunteers
This trial uses controlled, short-term pain testing (a “pain study”) to better understand how pain works during and after certain cancer treatments. It may help researchers improve how cancer therapy pain is measured and managed.
Houston, TexasAges 18 years+ - NCT00804154RecruitingPhase 1
Capsaicin-like drug for severe cancer pain
This Phase 1 trial tests a new drug related to capsaicin (resiniferatoxin) to reduce severe nerve pain from advanced cancer. It is given through a small catheter near the spinal fluid space and is meant for people whose pain medicines and other options have not worked well enough.
Bethesda, MarylandAges 18–99 - NCT01719055Recruiting
Long-term follow-up for Boston Scientific pain nerve stimulation
This study looks at how well a Boston Scientific nerve stimulation device works over the long term for pain in everyday care. You may be able to join if you’re already being set up to use one of these approved systems and can reliably report your pain outcomes.
Phoenix, ArizonaAges 18 years+ - NCT01765777Recruiting
Osteopathic hands-on therapy and light treatment for long-term low back pain
This trial studies whether hands-on osteopathic treatment and a type of light (phototherapy) can reduce chronic low back pain. It may help people who have had non-specific low back pain for at least 3 months.
Old Westbury, New YorkAges 18–65 - NCT02502162Recruiting
Low-dose naltrexone for complex regional pain syndrome
This trial tests whether low-dose naltrexone can reduce symptoms of complex regional pain syndrome (CRPS), a long-lasting pain condition in an arm or leg. It may help by targeting pain signaling, but you must meet specific CRPS diagnosis and medication rules to join.
Palo Alto, CaliforniaAges 18–70 - NCT02346396Recruiting
At-home brain stimulation trial for long-lasting nerve pain
This study tests a device that delivers mild electrical stimulation to the brain from home to help reduce chronic nerve pain. It focuses on people whose pain has not improved enough despite stable pain medicines.
BronAges 18–80 - NCT03137472Recruiting
Brain stimulation to treat complex regional pain syndrome
This trial studies whether noninvasive brain stimulation (TMS) can reduce pain in people with complex regional pain syndrome (CRPS). It may help if your CRPS has lasted at least a few months and you can safely undergo the stimulation and study tasks.
Redwood City, CaliforniaAges 18–70 - NCT02991625Enrolling by invitation
Brain scan study to find markers for chronic back pain
This study uses brain imaging (MRI scans) to look for “biomarkers” (measurable signs) that may relate to chronic low back pain. It compares people with long-lasting back pain to healthy volunteers to understand what brain patterns are linked to pain.
Halifax, Nova ScotiaAges 18–75 - NCT02352116Recruiting
Pain treatment plan after outpatient surgery for young children
This study tests a pain-management plan right after surgery for children ages 1–6 who go home the same day. It aims to see whether the plan improves comfort after anesthesia without requiring longer hospital recovery.
New York, New YorkAges 1–6 - NCT07399860RecruitingPhase 2
Botox before hemorrhoid surgery to reduce pain after surgery
This trial tests whether injecting botulinum toxin (Botox) into the anal muscle before hemorrhoid removal surgery can lower pain after the operation. It is for people with advanced hemorrhoids that have not gotten better with other treatments and who are already planning to have surgery.
Moscow, MoscowAges 18 years+ - NCT07401147Recruiting
TENS for pain relief during first labor
This trial tests a gentle electrical device (TENS) to help manage pain during labor. It's for women having their first baby, with a healthy, single pregnancy, and no major health issues.
Tegucigalpa, Francisco Morazán DepartmentAges 18–45 - NCT07410000Recruiting
Block for pain after hip replacement
This trial tests a nerve block to reduce pain after hip replacement surgery. It may help you need fewer painkillers and recover more comfortably.
BursaAges 18–80 - NCT07411417Recruiting
Acupressure for pain and lung function after chest surgery
This trial tests if acupressure can help reduce pain and improve lung function after a first-time chest surgery. It may offer a non-drug way to support recovery.
IstanbulAges Any age
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.