Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,136 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04134702Recruiting
Acupuncture for less pain after outpatient knee surgery
This study tests whether acupuncture can reduce pain after outpatient arthroscopic knee surgery done under general anesthesia. It may help by improving pain control while avoiding certain medicine side effects, but you must meet several specific safety and medication limits.
Greifswald, VorpommernAges 19–55 - NCT04109638Recruiting
PEMF therapy to reduce pain after shoulder or knee surgery
This trial studies whether PEMF, a type of non-surgical device that uses pulsed electromagnetic fields, can reduce pain after shoulder or knee surgery. If you join, you’ll also be expected to do post-surgery physical therapy exercises and report your pain and function.
Redwood City, CaliforniaAges 18 years+ - NCT03906422Recruiting
Study of pain after placing braces archwire
This study compares how much pain people feel after their braces archwire is first put in. It may help orthodontists choose approaches that make the early pain experience easier.
Aurora, ColoradoAges 12 years+ - NCT03912519Enrolling by invitation
Testing two ways to numb lumbar back pain with radiofrequency
This study compares two needle-based techniques to treat long-lasting low back pain by stopping overactive pain signals from specific back joints. If you’ve already tried physical therapy and pain medicines without enough relief, this trial may test which technique works better for pain reduction.
Nashville, TennesseeAges 40 years+ - NCT03737292RecruitingPhase 4
Numbing medicine for chest surgery pain after small lung operations
This trial tests whether a long-lasting numbing shot (liposomal bupivacaine) works better than a regular numbing shot (plain bupivacaine) for pain after minimally invasive chest surgery. It may help you have less post-surgery pain and potentially use less pain medication.
Hershey, PennsylvaniaAges 18 years+ - NCT03794466Recruiting
Study pain relief after blocking gonadal veins for pelvic congestion
This study looks at how much pelvic pain improves after a procedure called gonadal vein embolization (blocking problem veins). It mainly applies to people diagnosed with pelvic congestion syndrome caused by venous (vein) problems, treated during a specific time window.
Kansas City, KansasAges 18 years+ - NCT03823534RecruitingPhase 3
Study pain control after preventive femur bone surgery
This Phase 3 study tests a pain medicine plan used after preventive surgery to place a metal rod inside the thigh bone (femur) before a fracture happens. The goal is to find an approach that controls post-surgery pain while being safe for the right patients.
St Louis, MissouriAges 18 years+ - NCT03858205Recruiting
Low-dose radiation to relieve pain from bone tumors
This trial studies whether low-dose radiation can reduce pain from a specific bone lesion caused by multiple myeloma. It may help people whose main problem is painful bone metastasis, with targeted treatment to the painful spot.
Duarte, CaliforniaAges 18 years+ - NCT03836248Recruiting
Osteopathic care added to standard treatment for chronic low back pain
This study tests whether adding osteopathic treatment to usual medical care can improve chronic low back pain. It focuses on people whose back pain has no clear structural cause and has lasted more than 3 months.
ToulouseAges 18–64 - NCT03695887RecruitingEarly Phase 1
Disposable nitrous oxide for pain during burn dressing changes
This early-stage study tests whether using disposable nitrous oxide canisters can better control pain when you need burn dressing changes. It may help by making dressing changes more comfortable, but eligibility depends on your burn size, health, and breathing ability.
Winnipeg, ManitobaAges 18 years+ - NCT03705598Recruiting
Tai chi for older adults with chronic pain
This study tests whether practicing Tai Chi can reduce pain and improve balance in older adults who have chronic pain in multiple areas. Tai Chi is a gentle form of exercise that involves slow movements and breathing, and it may help you feel better and reduce your risk of falling.
Boston, MassachusettsAges 65 years+ - NCT03415620Recruiting
Music listening during surgery to reduce anxiety and pain
This study tests whether listening to music around the time of surgery can lower anxiety and pain, reduce how much pain medicine you need, and improve satisfaction. You may be asked to fill out brief questionnaires before and after your procedure.
SingaporeAges 21–70 - NCT03446456RecruitingPhase 1/Phase 2
Vasopressin and pain perception study
This trial tests whether vasopressin, a nasal spray, changes how your brain processes pain. You will receive either the spray or a placebo and have an MRI scan to see brain activity.
Baltimore, MarylandAges 18–65 - NCT03184545RecruitingPhase 3
Electrical stimulation vs physical therapy for knee pain
This trial compares an electrical stimulation treatment to standard physical therapy for people with long-lasting pain in the front of the knee. It aims to see which approach better improves symptoms and function for patellofemoral pain syndrome.
New York, New YorkAges 18–40 - NCT03137472Recruiting
Brain stimulation to treat complex regional pain syndrome
This trial studies whether noninvasive brain stimulation (TMS) can reduce pain in people with complex regional pain syndrome (CRPS). It may help if your CRPS has lasted at least a few months and you can safely undergo the stimulation and study tasks.
Redwood City, CaliforniaAges 18–70 - NCT02991625Enrolling by invitation
Brain scan study to find markers for chronic back pain
This study uses brain imaging (MRI scans) to look for “biomarkers” (measurable signs) that may relate to chronic low back pain. It compares people with long-lasting back pain to healthy volunteers to understand what brain patterns are linked to pain.
Halifax, Nova ScotiaAges 18–75 - NCT02352116Recruiting
Pain treatment plan after outpatient surgery for young children
This study tests a pain-management plan right after surgery for children ages 1–6 who go home the same day. It aims to see whether the plan improves comfort after anesthesia without requiring longer hospital recovery.
New York, New YorkAges 1–6 - NCT01719055Recruiting
Long-term follow-up for Boston Scientific pain nerve stimulation
This study looks at how well a Boston Scientific nerve stimulation device works over the long term for pain in everyday care. You may be able to join if you’re already being set up to use one of these approved systems and can reliably report your pain outcomes.
Phoenix, ArizonaAges 18 years+ - NCT00515060Recruiting
Study pain testing in cancer patients and healthy volunteers
This trial uses controlled, short-term pain testing (a “pain study”) to better understand how pain works during and after certain cancer treatments. It may help researchers improve how cancer therapy pain is measured and managed.
Houston, TexasAges 18 years+ - NCT00804154RecruitingPhase 1
Capsaicin-like drug for severe cancer pain
This Phase 1 trial tests a new drug related to capsaicin (resiniferatoxin) to reduce severe nerve pain from advanced cancer. It is given through a small catheter near the spinal fluid space and is meant for people whose pain medicines and other options have not worked well enough.
Bethesda, MarylandAges 18–99 - NCT07878273Recruiting
Tibial nerve size in chronic plantar fasciitis
This study compares the size of a nerve in the foot (the tibial nerve) between people with chronic plantar fasciitis and healthy individuals. It aims to understand if nerve changes are linked to this condition, which might help improve future treatments.
IstanbulAges 18–65 - NCT07877376Recruiting
How thinking problems affect pain in breast cancer survivors
This study looks at whether mild memory or thinking issues after breast cancer treatment are linked to ongoing pain. If you join, you will help doctors understand this connection, which may lead to better pain care.
Boulogne-Billancourt, IDEAges 35–65 - NCT07878533RecruitingPhase 2
Ear surgery pain relief with added medication
This study tests whether adding a sedative medicine to the numbing shot around the ear nerve can improve pain control during and after middle ear surgery. It aims to make the procedure more comfortable and reduce the need for strong painkillers.
MinyaAges 18–70 - NCT03427736Recruiting
Anesthetics and pain medicines study for children
This study looks at how children process certain anesthetics and pain medicines. It aims to find the best doses for safety and effectiveness.
Stanford, CaliforniaAges 6 months–17 years
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,136 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.