Pediatric Patients clinical trials

Study of activity and muscle function in children with scoliosis

This study looks at how children’s activity levels and muscle performance change in different scoliosis treatments (surgery, bracing, or healthy peers). It uses motion sensors and an ultrasound-based test to better understand what treatments may do to the body’s muscles.

Blood-plasma study of botulism antitoxin in children

This trial studies how a botulism antitoxin (called BAT, heptavalent) moves through the body in children. It may help doctors better choose doses and timing for pediatric treatment by learning from blood samples after the first dose.

Lifestyle coaching for children at high cardiometabolic risk

This study tests a tailored lifestyle program (changes around food and activity) for children who have higher-than-average weight for their age. It may help improve health habits and reduce future risk related to heart and metabolic health.

Study for children with antiphospholipid syndrome and blood clots

This study is for children who have antiphospholipid syndrome (APS) and a history of blood vessel clots. Researchers want to learn more about APS in pediatric patients who have specific blood test signs and clot history.

Repotrectinib safety study in Japanese children with NTRK fusion tumors

This study tracks the safety and effects of the drug repotrectinib in children aged 4 to under 18 with certain tumors that have a specific genetic change (NTRK fusion). The goal is to see how well the drug works in everyday medical practice in Japan.

Comparing two pain blocks for children having testicle surgery

This study compares two pain-relief techniques (erector spinae plane block vs. caudal block) in children aged 1 to 7 years undergoing orchiopexy (surgery for an undescended testicle). The goal is to see which method provides better pain control after surgery. Your child must be generally healthy and meet specific criteria to participate.

Pain Relief for Perineal Surgery in High-Risk Children

This trial tests pain-relief methods for children with serious health conditions who need surgery in the perineal area (around the genitals and anus). The goal is to find safe, effective ways to manage pain for kids whose bodies are at higher risk during surgery.

Comparing two pain blocks for children after chest surgery

This study compares two types of nerve blocks to see which provides better pain relief for children after chest surgery. The goal is to reduce pain and improve recovery.

Evaluation of Aortic-Radial Blood Pressure Gradient in Pediatric Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass

Testing a robotic exoskeleton for children with walking difficulties

This trial tests a robotic exoskeleton called ABLE Kids to help children with walking difficulties due to neurological or muscle conditions. It checks if the device is safe and works well. Children who meet certain size and health requirements may be eligible to participate.

Adalimumab Safety and Effectiveness in Children With Crohn's Disease

This study tracks how well and how safely a medicine called adalimumab works in children ages 6–17 with moderate-to-severe Crohn's disease (a condition causing inflammation in the digestive tract). Your child's doctor has already decided adalimumab is appropriate for them, and this study simply collects information about how they respond to it.

Airway tubes and stomach fullness in children undergoing surgery

This study compares how much air enters the stomach during surgery when using three different breathing tubes in children ages 1–10. The goal is to understand which tube design is safest and causes the least stomach bloating during anesthesia.

Atrasentan for children with IgA nephropathy

This trial tests an experimental medicine called atrasentan for children aged 2 to under 18 with IgA nephropathy, a kidney disease. The study aims to see if the drug can help protect kidney function and reduce protein in the urine, with fewer side effects than current treatments.

Operation Calm virtual reality study for children and teens

This study tests a virtual reality (VR) tool called Operation Calm to help children and teens feel calmer during medical, dental, or other procedures. Parents and healthcare workers also try it and share their thoughts.

Follow-up study for children with primary hyperoxaluria type 1 treated with lumasiran

This study follows children who have primary hyperoxaluria type 1 (PH1) and are being treated with lumasiran. The goal is to monitor their health and treatment progress over time.

Nutrition assessment for children with protein metabolism disorders

This study looks at the nutrition, body composition, and diet of Filipino children with protein metabolism disorders. It aims to understand their current health to improve future care and treatment.

Comparing two airway devices for stomach air in children during short surgeries

This trial compares two devices used to help children breathe during surgery (LarySeal Pro and Ambu AuraGain). It measures how much air gets into the stomach, which can cause discomfort. It is for children aged 6–12 having short elective surgeries (1 hour or less).

IV Tylenol for Pain and Agitation After Throat Surgery in Young Children

This study tests whether giving acetaminophen (Tylenol) through an IV (a vein) instead of by mouth helps reduce pain and fussiness after tonsil and adenoid removal in children age 7 and under. The goal is to find better ways to keep children comfortable during recovery.

Online brain training and mindfulness for kids after leukemia treatment

This study tests if a computer-based training program focusing on thinking skills and mindfulness can help children and teens who have had leukemia treatment. It may help improve memory, attention, and emotional well-being.

Medicine via nose for less pain after tonsil surgery in kids

This trial tests whether giving two medicines (dexmedetomidine and esketamine) through the nose can help children ages 3-7 have less pain after their tonsil or adenoid surgery. The goal is to find a better way to manage pain without using strong drugs.

Dust mite allergy shot therapy for kids with rhinitis or asthma

This trial tests allergy shots for children with dust mite allergies causing rhinitis or asthma. It aims to see if guiding treatment with detailed allergy testing leads to better results.

IV catheter use study in children in the ER

This study looks at how IV catheters work in children who come to the emergency room and need an IV for at least 24 hours. It will help doctors understand the best ways to use and care for IVs in kids.

Laser therapy for mouth sores in children having a bone marrow transplant

This study tests whether a special kind of laser therapy (called high-level laser therapy) can help heal severe mouth sores in children who are having a bone marrow transplant. If your child has painful mouth sores from the transplant, this treatment might reduce pain and speed healing.

Helping Young Cancer Patients Talk with Their Care Team

This study works with teens and young adults (ages 15–25) who have cancer and are currently in treatment. It tests a way to help you talk better with your doctors and nurses about your care, so they can understand your needs and preferences more clearly.