Clinical trials
Peripheral Arterial Disease clinical trials
Below are recruiting peripheral arterial disease clinical trials, each written for real people, not researchers. We’re tracking 215 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05880641Recruiting
Shockwave balloon treatment for very hard, blocked iliac arteries
This trial tests a device called Shockwave M5+/L6 intravascular lithotripsy to help deliver stent grafts when the iliac (pelvic) arteries are extremely calcified and hard to access. It may help people who are being evaluated for endovascular (through-the-blood-vessel) treatment but whose anatomy makes standard access difficult.
Ancona, AnconaAges 18 years+ - NCT05811364Recruiting
Stent versus bare-metal treatment for blocked leg arteries
This study compares a new balloon-expandable stent to standard bare-metal stenting to treat complex blockages in the iliac arteries (main blood vessels to the legs). It may help people with symptoms like leg pain with walking, pain at rest, or minor tissue injury by improving blood flow and reducing repeat procedures.
Little Rock, ArkansasAges 18 years+ - NCT05712395Recruiting
Pain-free exercise program for people with leg artery disease
This trial tests a new kind of exercise that is meant to be non-ischemic (not reduce blood flow) and pain-free, to see if it helps people with peripheral artery disease (PAD) who get leg pain when walking. You may be eligible if you have PAD confirmed by specific treadmill and blood-pressure measurements and meet the exercise and health safety requirements.
Oklahoma City, OklahomaAges 40 years+ - NCT05628948Recruiting
Donate blood for a heart and metabolism research biobank
This study builds a “biobank,” which is a collection of blood and related samples, to support future research on heart and metabolic (sugar/body-fat) conditions. It may help researchers better understand these diseases and improve future prevention and treatments.
Cleveland, OhioAges 18 years+ - NCT05465070Recruiting
Heat therapy trial for leg blood-flow problems
This trial studies whether applying heat to your legs can improve symptoms and function in people with peripheral artery disease (reduced blood flow to the legs). You may be tested with a simple blood-flow check and an MRI scan, depending on eligibility.
Indianapolis, IndianaAges 50 years+ - NCT05145478Recruiting
Real-world outcomes after Shockwave treatment for blocked leg artery
This study follows what happens in real life after using Shockwave’s device (intravascular lithotripsy) to treat a hard, calcified blockage in the common femoral artery, then completing standard treatment. It may help doctors understand which patients benefit and what results to expect.
New Haven, ConnecticutAges 18 years+ - NCT05134311Recruiting
3D ultrasound check for blood-flow problems in wound care
This study tests whether a 3D ultrasound scan can better assess blood-flow problems that may affect healing in the wound clinic. If you’re already scheduled for an ultrasound evaluation at the wound center, the trial may use an additional 3D ultrasound approach to help doctors understand your circulation.
Lake Success, New YorkAges 18 years+ - NCT04774159RecruitingPhase 3
Low-dose colchicine to lower risk in leg artery disease
This trial tests whether low-dose colchicine can reduce “residual” risk—future heart and blood-vessel problems—in people with peripheral artery disease (PAD). It targets PAD symptoms and complications like poor blood flow in the legs, even after certain procedures.
New Haven, ConnecticutAges 18 years+ - NCT04800276Recruiting
Exercise program for leg artery disease
This trial tests a supervised exercise program for people with leg pain when walking caused by narrowed leg arteries. The goal is to see if exercise can improve walking ability and quality of life.
Le MansAges 18 years+ - NCT04584632Recruiting
Stent-like device for blocked leg arteries in the thigh or knee
This trial studies a new stent-like vascular scaffold to improve blood flow in people with symptomatic blockage in the thigh/knee artery. It may help reduce symptoms from narrowed or blocked arteries, but you must meet several artery and health requirements.
Sydney, New South WalesAges Any age - NCT04347200Recruiting
Long-term blood-thinner therapy registry for heart disease
This study follows people with known coronary artery disease to understand how long-term “blood thinner” treatments are used and how they affect health over time. You may be asked to share medical information and come in for follow-up to help researchers compare outcomes.
MoscowAges 18 years+ - NCT03791970Recruiting
Compare stent post-dilation using drug balloon or regular balloon
This study looks at whether using a drug-coated balloon (DCB) versus a regular balloon (POBA) right after placing a stent works better in artery blockages in the thigh/knee area. It may help improve blood flow and reduce the chance the artery narrows again.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT03845036Recruiting
Diet and exercise study for leg circulation problems
This study looks at how diet changes and an exercise program may improve walking and leg symptoms in people with peripheral artery disease (PAD). You may be eligible if you have a history of claudication (leg pain with walking) and tests or treatment history show PAD.
Oklahoma City, OklahomaAges 40 years+ - NCT03663777Recruiting
Hand strength training for women with poor leg blood flow
This trial tests whether guided handgrip (hand strength) exercises can improve health in post-menopausal women who have reduced blood flow to the legs. It may help your circulation and overall function, as long as you can safely do the training and keep your current medications during the study.
São Paulo, São PauloAges 45 years+ - NCT03203239Recruiting
Red light treatment for circulation problems in leg arteries
This study tests whether a red-light therapy can improve symptoms or function in people with peripheral artery disease (poor blood flow to the legs). You may qualify if your leg circulation test is abnormal and you can safely take part in the study.
Milwaukee, WisconsinAges 18–85 - NCT01904851Recruiting
Registry for leg artery procedures and their outcomes
This study collects information about people who had a procedure to improve blood flow in certain leg arteries. It helps researchers understand which treatments work best and what outcomes to expect.
Little Rock, ArkansasAges Any age - NCT06274697Recruiting
Testing a magnetic sensor for artery blood flow
This study tests a new magnetic sensor that measures blood flow in your arteries, comparing it to the standard method. It takes place in the heart-lung unit at Montpellier University Hospital, and aims to see if the sensor is accurate for people with or without leg artery disease.
MontpellierAges 18 years+ - NCT05307263Recruiting
Atherectomy plus drug balloon versus drug balloon alone
This study compares two ways to treat complex blockages in the thigh/knee artery: using atherectomy followed by a medicated balloon versus using a medicated balloon by itself. It may help your care team learn which approach works best to open the artery and improve leg symptoms.
SeoulAges 19–85 - NCT06794359Enrolling by invitation
Comparing minimally invasive vs. traditional bypass for multi-vessel heart disease
This study compares two types of heart bypass surgery for people with blockages in multiple heart arteries: a newer, less invasive technique (minimally invasive CABG) versus the traditional open-chest approach. It aims to see which approach leads to better recovery and outcomes.
São Paulo, São PauloAges 18 years+ - NCT06206369Recruiting
Ai tool for predicting vascular disease risk
This study is collecting medical information from people with abdominal aortic aneurysms or peripheral artery disease to build an AI tool that can better predict how these conditions progress. The goal is to help doctors give more personalized care.
HelsinkiAges 40–90 - NCT04927156Recruiting
Check safety and use of Balt medical devices after treatment
This post-marketing study follows people after they receive Balt medical devices to make sure the devices are safe, work well, and are easy to use in real life. You may be considered if you can consent and your procedure matches their device-use rules.
AngersAges 2 years+ - NCT06315023Enrolling by invitation
A registry study for the DETOUR system
This study is collecting information from people who receive the DETOUR system, a treatment for blocked arteries. The goal is to see how well it works in real-world use.
Salinas, CaliforniaAges Any age - NCT07157475Recruiting
Blood vessel complications after leg artery procedures with SGLT2 inhibitors
This study looks at how a type of medicine called SGLT2 inhibitors (used for diabetes, kidney disease, or heart issues) affects blood vessel complications in people who have had a leg procedure to improve blood flow. It compares patients taking the medicine to those who are not.
Wroclaw, Lower Silesian VoivodeshipAges 18 years+ - NCT03395509Enrolling by invitation
Free screening program for diabetes and heart risks
This study looks at how well and how cost-effective a combined health screening is for diabetes and cardiovascular (heart and blood vessel) risks. You may be invited to attend screening around your 67th birthday.
ViborgAges 67–67
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Common questions
- Are there clinical trials for peripheral arterial disease?
- Yes. Clin2 currently lists 215 recruiting peripheral arterial disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a peripheral arterial disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a peripheral arterial disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.