Clinical trials
Peripheral Arterial Disease clinical trials
Below are recruiting peripheral arterial disease clinical trials, each written for real people, not researchers. We’re tracking 215 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06952543Recruiting
Ultrasound blood flow test for leg artery disease
This study uses ultrasound to measure blood flow in the legs of people with PAD symptoms and healthy volunteers. It aims to improve how doctors assess peripheral arterial disease without invasive tests.
Rochester, MinnesotaAges 18–75 - NCT06933992Enrolling by invitation
Chocolate balloon for blocked leg arteries
This trial tests a special balloon called the Chocolate Balloon Catheter to open blocked leg arteries. It may help people with peripheral artery disease avoid more invasive surgery.
HangzhouAges 18–80 - NCT06410521Recruiting
Personalized exercise program for peripheral arterial disease
This trial tests a personalized exercise program for people with peripheral arterial disease (PAD), a condition that causes leg pain when walking. The goal is to see if a tailored exercise plan can help reduce pain, improve walking distance, and boost quality of life.
Vila RealAges 18 years+ - NCT06631378Recruiting
Groin incision direction study for vascular surgery patients
This trial compares two different ways of making an incision (cut) in the groin during blood vessel surgery. It aims to find out if one direction leads to better healing or fewer complications.
KoldingAges Any age - NCT04511234Recruiting
Sirolimus-coated balloon vs standard balloon for leg artery narrowing
This trial compares two balloon treatments used during a procedure to open blocked or narrowed arteries in the thigh and behind the knee. It tests whether the sirolimus-coated balloon works better at keeping the artery open than a standard balloon.
SingaporeAges 21 years+ - NCT04511247Recruiting
Drug-coated balloon for artery disease below the knee
This trial tests a drug-coated balloon to open narrowed or blocked arteries in the lower leg (below the knee) and help them stay open. It’s meant for people with significant symptoms, to reduce re-narrowing after treatment.
SingaporeAges 21 years+ - NCT06782100Recruiting
MRI-Guided Treatment for Severe Leg Artery Blockages
This study uses MRI to guide treatment of blocked leg arteries below the knee, aiming to improve blood flow and reduce severe pain or sores.
Houston, TexasAges 18 years+ - NCT06686121RecruitingPhase 3
Walking recovery after leg artery treatment
This study tests whether a home-based exercise program or a special beetroot drink can help people walk better after having a procedure to improve blood flow in their legs. It aims to find ways to boost mobility and quality of life.
Tucson, ArizonaAges 18 years+ - NCT06542432Enrolling by invitation
Genetic risk test for heart disease prevention
This trial uses a polygenic risk score to see if knowing your genetic risk for coronary artery disease can help prevent a first heart attack. If you have an intermediate 10-year risk and no prior heart events, you may be eligible.
Rochester, MinnesotaAges 40–70 - NCT05854641RecruitingPhase 4
Stem cell treatment for poor blood flow in the leg ulcers
This trial tests whether a stem cell product (Stempeucel®) can improve healing and safety for people with critical limb ischemia caused by peripheral artery disease. It is for patients who cannot have (or have already tried) procedures to reopen blocked leg arteries and who have a leg ulcer and low blood-flow measurements.
Kuala LumpurAges 18–65 - NCT06480786Recruiting
Spinal cord stimulator for diabetic nerve and artery pain
This study tests if a spinal cord stimulator (a device that sends mild electrical pulses to the spine) can relieve severe leg pain caused by diabetic nerve damage and poor blood flow. It may help people who have not found enough relief from other treatments.
Omaha, NebraskaAges 19–89 - NCT06399900Recruiting
Light therapy plus exercise for better walking with PAD
This study tests whether adding light therapy to a walking program helps people with peripheral artery disease (PAD) walk further and feel better. You'll receive either light therapy or a placebo light while doing a supervised exercise program.
Chicago, IllinoisAges 50 years+ - NCT06399809RecruitingPhase 2
Fisetin for better walking in peripheral artery disease
This study tests whether a supplement called fisetin can help reduce leg pain and improve walking ability in people with peripheral artery disease (PAD). If you have PAD and are 50 or older, you may be able to join and help see if fisetin can make walking easier.
Chicago, IllinoisAges 50 years+ - NCT06321575Recruiting
New device for clearing leg artery blockages
This trial tests a new device called the Golazo® Atherectomy System that removes plaque from leg arteries to improve blood flow. It may help people with leg pain when walking or small wounds caused by blocked arteries.
Scottsdale, ArizonaAges 18 years+ - NCT06318767Recruiting
Foot Blood Flow Measurements to Predict Limb and Heart Events
This study measures how blood flows through your foot using ultrasound to see if it can predict serious problems with your leg or heart in people with severe circulation problems. The goal is to find a simple test that helps doctors decide the best treatment for you.
AmiensAges 18 years+ - NCT06319339RecruitingEarly Phase 1
Studying a drug to improve walking in peripheral artery disease
This trial tests whether a drug called diroximel fumarate (Vumerity) can improve blood flow and walking ability in people with peripheral artery disease (PAD). It compares people with PAD to healthy volunteers of the same age.
Omaha, NebraskaAges 50–75 - NCT06308562Recruiting
Fuzzy sock after leg amputation to help healing
This trial tests a fuzzy compression sock worn on the leg after amputation below the knee (transtibial amputation). The goal is to see if it helps the wound heal better in people with peripheral artery disease.
Rochester, MinnesotaAges 18 years+ - NCT06300450Recruiting
Alert test for cholesterol meds in PAD patients
This study tests whether a special alert in your electronic health record can help doctors start the right cholesterol-lowering medication for people with peripheral artery disease (PAD) who are not already on one. The goal is to see if the alert helps get treatment started more often.
Boston, MassachusettsAges 18 years+ - NCT06215248Recruiting
Heart function study in leg artery disease patients
This trial uses ultrasound to check how well the heart pumps in people with blocked leg arteries. It aims to find early signs of heart strain that standard tests might miss.
TartuAges 35–85 - NCT06182397Recruiting
Drug-coated balloon for leg artery blockages below the knee
This trial tests a special balloon coated with sirolimus (a drug that helps prevent arteries from re-closing) versus a standard balloon for opening blocked arteries below the knee in people with severe leg pain or foot wounds. The goal is to see if the drug-coated balloon works better to keep the artery open longer.
Scottsdale, ArizonaAges 21 years+ - NCT06033924Recruiting
Home Walking Program for Vets with Leg Artery Disease
This study tests a home-based walking program delivered through telehealth for Veterans with peripheral artery disease (PAD). It aims to help you walk farther with less pain.
Birmingham, AlabamaAges 21 years+ - NCT06041880Recruiting
Calf Stretching for Better Walking in PAD
This study tests whether a simple daily calf-stretching routine can improve walking ability and blood flow in people with peripheral artery disease. It offers a non-drug, non-surgical approach that you can do at home.
University Park, PennsylvaniaAges 40–85 - NCT06032065RecruitingPhase 3
Exercise for peripheral artery disease
This trial tests whether a home-based exercise program is as effective as supervised exercise for improving walking ability in people with peripheral artery disease (PAD). You will be randomly assigned to one of two exercise groups, and you may be asked to drink beetroot juice as part of the study.
Chicago, IllinoisAges 50 years+ - NCT05916950Recruiting
Study of a new treatment for blocked leg arteries
This trial studies a device-based treatment approach for people with blocked (narrowed or fully blocked) arteries in the thigh or behind the knee that reduce blood flow to the leg. It may help improve blood flow and walking ability, but you must meet specific artery and imaging requirements.
St. Helena, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for peripheral arterial disease?
- Yes. Clin2 currently lists 215 recruiting peripheral arterial disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a peripheral arterial disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a peripheral arterial disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.