Clinical trials
Peripheral Arterial Disease clinical trials
Below are recruiting peripheral arterial disease clinical trials, each written for real people, not researchers. We’re tracking 215 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06260488Recruiting
Using AI to study leg arteries before amputation
This trial uses artificial intelligence to analyze CT scans and microscope images of the main leg artery. It aims to improve understanding of artery structure. Participation is only for patients who are already scheduled for a leg amputation as part of their medical care.
Strasbourg, Bas-RhinAges 18 years+ - NCT06687590Recruiting
Serranator POINT FORCE registry for leg and dialysis access
This registry study is following patients whose blocked leg or dialysis access arteries are treated with a special balloon (Serranator) that helps open the vessel. The goal is to see how well the device works in real-world use.
Scottsdale, ArizonaAges 18 years+ - NCT06271590Recruiting
Drug-coated balloon for small heart artery blockages
This trial tests a special balloon coated with a drug (sirolimus) to treat blockages in small heart arteries. If the balloon is successful, it may help keep the artery open without needing a permanent stent.
Gilbert, ArizonaAges 18–80 - NCT05055297Recruiting
Drug-coated balloon for severe leg artery blockage in lower legs
This trial studies a “drug-coated balloon” procedure to improve blood flow in people with severe, long-lasting poor circulation in the lower leg arteries. It may help reduce repeat blockage after treatment for selected artery lesions below the knee.
Chandler, ArizonaAges 18 years+ - NCT07524335RecruitingPhase 3
Aspirin for early coronary artery disease without symptoms
This trial tests whether taking aspirin can help people who have early signs of coronary artery disease (buildup in heart arteries) but have never had a heart attack or stroke. The goal is to see if aspirin prevents future heart problems in these patients.
Montreal, QuebecAges 40 years+ - NCT06277362Recruiting
New Leg-Saving Treatment for Critical Limb Ischemia
This study tests a new way to restore blood flow to the leg in people who have wounds or dead tissue on their foot and have run out of other treatment options. It's for those who have already tried angioplasty twice without success or have severely hardened small arteries.
Ancona, AnconaAges 18 years+ - NCT03195556Recruiting
Test ultrasound contrast to improve blood flow in legs
This study checks whether using a special ultrasound with contrast can improve blood flow in people with peripheral artery disease (PAD). If you have leg circulation problems, it may help doctors measure and potentially enhance how well blood reaches your limb.
Portland, OregonAges 19–99 - NCT05749250Recruiting
Ultrasound treatment for severe leg artery disease ulcers
This trial studies a specific ultrasound-based treatment aimed at improving healing of severe circulation-related ulcers in the legs. It may help if you have poor blood flow and a wound that hasn’t improved despite usual care.
Charlottesville, VirginiaAges 18 years+ - NCT05612945Recruiting
High-intensity versus easier walking exercise for PAD symptoms
This study tests whether harder interval exercise works better than easier, moderate exercise to improve walking symptoms in people with peripheral artery disease (PAD). It may help you compare which exercise level improves your ability to walk comfortably.
Lausanne, Canton of VaudAges 18 years+ - NCT04885985Recruiting
Check a new treatment for blocked leg arteries after procedures
This post-market study follows people with significant below-the-knee artery blockages to see how a treatment performs over time. It may help patients by confirming the safety and ongoing effectiveness of the device used for these leg artery problems.
Beijing, Beijing MunicipalityAges 18–75 - NCT04393389Recruiting
Follow-up study for a drug-coated balloon in leg arteries
This is a post-market follow-up study of a drug-coated balloon used to open blocked leg arteries. It checks how safe the device is and how well it works over time after your procedure.
Halle, Saxony-AnhaltAges 18 years+ - NCT06566976Recruiting
Exercise before and after stent for PAD
This study tests a program of exercise before and after a stent procedure for people with peripheral artery disease who have leg pain while walking. The goal is to see if this helps improve walking ability and recovery.
Palo Alto, CaliforniaAges 18 years+ - NCT06237621Recruiting
Using a special camera to check leg circulation
This study tests a special camera (SnapshotNIR) that takes pictures of blood flow in your legs while you move them into different positions. It may help doctors better understand your circulation and diagnose peripheral artery disease (PAD) without needles or dye.
San Antonio, TexasAges 35–99 - NCT07619885RecruitingPhase 1
Testing a New Blood Thinner Called CG-0255 in Healthy People
This study tests how a new blood-thinning medication (CG-0255) works in the body and compares it with Plavix, a common blood thinner. Researchers will measure how much of the drug enters your bloodstream and what effects it has on your blood clotting ability.
Miami, FloridaAges 18–55 - NCT06713850Recruiting
Balloon treatment for leg artery blockages with calcium
This trial uses a special balloon (Shockwave IVL) to break up calcium in leg artery blockages, improving blood flow and reducing pain. It's for people with moderate to severe calcium buildup in the femoropopliteal artery.
Wuhan, HubeiAges 18 years+ - NCT07385573Recruiting
Testing a drug-coated balloon for leg artery blockages
This trial tests a special balloon that releases medication to help keep leg arteries open. It's for people with narrowed or blocked arteries in the leg, either above or below the knee.
AalstAges 18–99 - NCT07181434Recruiting
Virtual reality for pain relief during leg artery repair
This trial tests whether using a virtual reality headset during a leg artery repair procedure can reduce pain. If you have peripheral artery disease and are having a minimally invasive leg artery surgery under local anesthesia with sedation, you may be able to participate.
PoitiersAges 18 years+ - NCT07161583Recruiting
Advanta VXT and Flixene Graft Registry
This registry follows people who have already received an Advanta VXT or Flixene graft to repair or replace a peripheral artery. It collects information from medical records to see how the grafts perform over time.
Boston, MassachusettsAges 18 years+ - NCT07130526Recruiting
Distrupt Stiffness: studying a new treatment for hardened leg arteries
This trial tests a new approach to treat severe, hardened blockages in the leg arteries. It may help people with painful leg symptoms or wounds that won't heal.
Essen, North Rhine-WestphaliaAges 18–85 - NCT07076082RecruitingPhase 4
Vascular trial registry for leg artery procedures
This study is a registry that collects information on people who have or will have a leg artery procedure to open blocked blood vessels. It helps doctors learn more about how well these procedures work and how to improve care.
Detroit, MichiganAges 45 years+ - NCT02842424RecruitingPhase 4
Ramipril for walking pain from blocked leg arteries
This study tests whether ramipril (a blood-pressure medicine) can improve leg muscle problems linked to poor blood flow in people with chronic claudication—pain that limits walking. It’s mainly looking at changes related to oxidative stress and muscle scarring (fibrosis).
Omaha, NebraskaAges 18–90 - NCT07016698Recruiting
Real-world registry study of the Rotarex device for clearing leg blockages
This study collects information on people who are treated with a device called Rotarex that uses a spinning tool to remove plaque from blocked leg arteries. It aims to understand how well the device works in real-world use to help patients with reduced blood flow to their legs.
Lakeland, FloridaAges 22 years+ - NCT06952998RecruitingPhase 4
Platelet-rich plasma for diabetic foot ulcers with artery disease
This trial tests if a special treatment made from your own blood (platelet-rich plasma) can help heal foot ulcers in people with diabetes and poor circulation in their legs. The goal is to see if it improves wound healing compared to standard care.
Bilbao, BizkaiaAges 18 years+ - NCT06263322Recruiting
Recovery tracking after leg artery surgery
This study tests a mobile app to track your recovery after surgery for severe leg artery disease. The goal is to see if using the app helps improve your recovery and quality of life.
Gainesville, FloridaAges 60–100
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Common questions
- Are there clinical trials for peripheral arterial disease?
- Yes. Clin2 currently lists 215 recruiting peripheral arterial disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a peripheral arterial disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a peripheral arterial disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.