Clinical trials
PFO clinical trials
Below are recruiting pfo clinical trials, each written for real people, not researchers. We’re tracking 23 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07698951Recruiting
Testing a new device to close PFO after stroke
This trial tests a new device to close a PFO (a small hole in the heart) in people who have had a stroke caused by a blood clot passing through that hole. The goal is to see if the device can prevent another stroke.
BelgradeAges 18–65 - NCT07172464Recruiting
Study of a new device to close a hole in the heart after a stroke
This trial tests a new device to close a PFO (a small hole between the upper chambers of the heart) in people who have had a stroke caused by a blood clot. The goal is to prevent future strokes by blocking the hole.
Los Angeles, CaliforniaAges 18–65 - NCT03821129Recruiting
Reduce recurrent stroke with a PFO closure device and antiplatelet pills
This study looks at whether closing a heart opening called a patent foramen ovale (PFO) with a special septal occluder, along with antiplatelet medications, can lower the risk of another stroke. It is for people who recently had a stroke thought to be caused by a clot that traveled from the heart but without another clear source.
Tucson, ArizonaAges 18–70 - NCT05387954RecruitingPhase 3
PFO closure or blood thinners after stroke in ages 60–80
This trial studies the best way to prevent another stroke after a recent stroke in people ages 60 to 80 who have a “PFO” heart connection. It compares closing the PFO vs taking mouth blood-thinners or antiplatelet medicine, based on what your doctors determine is safest for you.
AmiensAges 60–80 - NCT05537753Recruiting
PFO closure device test after recent unexplained stroke
This trial tests whether closing a hole in the heart (a PFO) with a special device can help prevent another stroke after an unexplained stroke. You may be a candidate if your stroke likely happened because blood can pass through this PFO.
Little Rock, ArkansasAges 18–60 - NCT06347276Recruiting
PFO closure and brain microemboli study
This trial looks at whether closing a small hole in the heart (PFO) can reduce tiny clots traveling to the brain. It includes people who have had a stroke or migraine, and also those without symptoms but with high-risk features.
Beijing, Beijing MunicipalityAges 18–65 - NCT06793969Recruiting
New method to close PFO hole in heart
This trial is testing a new way to close a small hole in the heart (called a PFO) using a thin tube and a guidewire to make the procedure smoother. It's for people who have had a stroke or mini-stroke and whose PFO is thought to be the cause.
ShanghaiAges 18–65 - NCT04339699Recruiting
PFO closure comparison trial for cryptogenic stroke
This trial studies ways to close a patent foramen ovale (PFO) to help prevent another stroke in people whose prior stroke had an unknown cause. If you qualify, you may receive one of the PFO closure approaches the study is comparing.
Tucson, ArizonaAges 18–60 - NCT05238610Recruiting
Registry for older adults with stroke of unclear cause and PFO
This study follows adults over 60 who had a stroke where the cause is unclear, and where a heart opening (PFO) may have contributed. It mainly collects information to better understand this stroke pattern and how these patients do over time.
SeoulAges 60 years+ - NCT06120270Recruiting
CeraFlex PFO closure study for migraine or stroke
This study tests a device called CeraFlex PFO Occluder to close a small hole in the heart (PFO) that may be causing migraines or strokes. If you have a PFO with related symptoms, the device might help prevent future events.
BremenAges 18–85 - NCT06156670Recruiting
A study of closing a PFO to prevent strokes
This trial looks at the safety and results of closing a PFO (a small hole in the heart) in people who have had a stroke or embolism with no other clear cause. If you qualify, doctors will close your PFO using a small tube inserted through a blood vessel and then follow your health over time.
MoscowAges 18–70 - NCT06203873Recruiting
Comparing biodegradable vs. metal heart-hole closures for migraine
This trial compares two types of devices (biodegradable vs. metal) to close a small hole in the heart (PFO) in people who have migraine not controlled by usual treatments. It aims to see which device works better to reduce migraine attacks.
Beijing, Beijing MunicipalityAges 18–65 - NCT07479147Recruiting
Stroke prevention in elderly by PFO closure vs blood thinners
This trial compares two treatments for preventing another stroke in older adults who have a PFO (a small hole in the heart). It tests whether closing the hole with a device works better than using blood-thinning medication.
TaichungAges 18–90 - NCT07724171Recruiting
Long-term results after PFO closure surgery
This study looks at how well patients do over time after having a hole in their heart (patent foramen ovale, or PFO) closed with a small device inserted through a vein. It may help doctors understand the benefits and risks of the procedure.
SeoulAges 19 years+ - NCT05907694Recruiting
Treatment of stroke from PFO, with or without closure
This study looks at whether treating a history of “cryptogenic” stroke (stroke with no clear cause) using a patent foramen ovale (PFO) closure, plus medical therapy, is better than medical therapy alone. It focuses on people over 60 with a heart shunt seen on an ultrasound of the heart.
Québec, QuebecAges 18 years+ - NCT06590467Recruiting
Abbott heart device registry study
This registry is a large, ongoing study that collects information about Abbott heart devices used in routine care. It helps doctors learn how well these devices work and how patients are doing over time, without changing your treatment plan.
New Brunswick, New JerseyAges Any age - NCT06863350Recruiting
Closing a heart hole to treat drug-resistant epilepsy
This trial tests if closing a small hole in the heart (called a PFO) can reduce seizures in people whose epilepsy isn't controlled by medication. It might offer a new treatment option for those who have both drug-resistant epilepsy and this heart condition.
Chengdu, SichuanAges 18–60 - NCT06983613Recruiting
New heart rhythm after PFO closure study
This study looks at whether closing a small hole in the heart (called a PFO) can cause new heart rhythm problems. It is for people who had a stroke caused by a PFO and are planning to have it closed.
PragueAges 18 years+ - NCT07170176Recruiting
PFO closure and migraine: can it help?
This trial tests if closing a common heart defect (PFO) can improve migraine symptoms and brain function. It compares people with migraine who get the closure procedure to those without migraine.
Luoyang, HenanAges 18–60 - NCT07349004Recruiting
Migraine with aura and PFO study
This study looks at the link between migraine with aura and a small hole in the heart called PFO. It may help researchers understand what causes migraines in some people.
Bologna, BOAges 18 years+ - NCT07414446Recruiting
Detecting lung blood flow issues with a new ultrasound device
This trial uses a non-invasive ultrasound device to detect abnormal blood flow connections in the lungs, which are common in people with hereditary hemorrhagic telangiectasia (HHT) or a type of stroke called cryptogenic stroke. The goal is to see if the device can find these issues safely and easily without needing an invasive procedure.
Nieuwegein, UtrechtAges 18 years+ - NCT07420400Recruiting
Detecting heart shunts without needles
This trial uses a specialized ultrasound test (TEE with bubble study) to find a small opening in the heart called a PFO. It may help people who need this test to check for causes of certain health problems.
La Jolla, CaliforniaAges 18 years+ - NCT07519876Recruiting
Blood Clots in the Lungs and Heart Shunts Study
This study looks at whether people with blood clots in their lungs have hidden holes in their hearts that let blood bypass normal circulation. Researchers will use imaging tests to understand this connection and see if it affects how patients do.
Boston, MassachusettsAges 18 years+
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Common questions
- Are there clinical trials for pfo?
- Yes. Clin2 currently lists 23 recruiting pfo studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pfo trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pfo trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.