Clinical trials
Post Operative Pain clinical trials
Below are recruiting post operative pain clinical trials, each written for real people, not researchers. We’re tracking 186 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07517679RecruitingPhase 4
Methadone for Pain After Spine Surgery
This study tests whether methadone, an opioid medication, can safely manage pain after elective spine surgery. Researchers want to see if it works well and is safe for patients staying overnight in the hospital after their procedure.
Lexington, KentuckyAges 18–120 - NCT07041424Enrolling by invitation
Bonding methods for filling cavities to reduce tooth sensitivity
This trial tests two ways of bonding a tooth-colored filling to see which reduces tooth sensitivity after the procedure. It may help if you have a moderate cavity on a back tooth that causes brief pain or sensitivity.
Islamabad, FederalAges 18 years+ - NCT05204472Recruiting
Deep brain stimulation for ongoing nerve pain after stroke or facial nerve issues
This trial studies whether a special brain device (deep brain stimulation, or DBS) can reduce long-lasting nerve pain. It focuses on one-sided pain after certain brain injuries or specific facial nerve pain causes, especially when medicines haven’t helped enough.
BernAges 18–75 - NCT06908538Recruiting
Cryo nerve block for pain after amputation
This study is testing a treatment called a cryo nerve block to reduce pain after amputation, including phantom limb pain. It will look at whether freezing the nerve during surgery helps people feel less pain and use less pain medicine.
Pittsfield, MassachusettsAges 18 years+ - NCT06808022Enrolling by invitation
Back exercises before spine surgery
This trial studies whether doing back exercises before spine surgery helps improve recovery. If you are having spine surgery and can safely do physical therapy, you may be able to join.
La Jolla, CaliforniaAges 18 years+ - NCT07173413Recruiting
Quality of phone check-ins after spine surgery
This study checks how well telephone follow-ups work for patients who had lower back surgery at a Danish hospital. It may help improve future care.
Aalborg, AalborgAges 18 years+ - NCT06555107Recruiting
Pain before emergency surgery and long-term pain after
This study looks at whether pain you feel before emergency surgery affects long-term pain after the surgery. It may help doctors find ways to prevent chronic pain in patients who have emergency orthopedic (bone/joint) or abdominal (belly) surgery.
AmiensAges 18 years+ - NCT06956950RecruitingPhase 2/Phase 3
Magnesium Added to Numbing Medicine for Hip Replacement Pain
This study tests whether adding magnesium sulfate to a numbing medicine (bupivacaine) can provide better pain relief after hip replacement surgery. The medicine is given as a shot in the back near the hip muscles.
Tanta, El-GharbiaAges 18 years+ - NCT06350409Recruiting
Opioid use after surgery in teens
This study looks at how teens aged 12–17 use opioids after a scheduled surgery. It aims to understand outcomes and help improve pain management.
Aurora, ColoradoAges 12–17 - NCT04576078RecruitingPhase 2
Nefopam for less pain after knee replacement surgery
This Phase 2 study tests whether oral nefopam can reduce pain after total knee replacement done with spinal anesthesia. It looks at whether this medicine works better than the usual post-surgery pain plan and how safely it can be used.
Lyon, LyonAges 18–75 - NCT06077422Enrolling by invitationPhase 2/Phase 3
Comparing two pain blocks for heart surgery recovery
This trial compares two types of pain blocks (Exparel vs. Marcaine) given during heart surgery to see which one provides better pain relief. If you are scheduled for a heart surgery through a small or full chest incision, you may be able to join.
New Brunswick, New JerseyAges 18 years+ - NCT07215546Enrolling by invitation
Stopping pain after heart surgery with a special chest closure
This trial tests a new device to close the breastbone after open-heart surgery to see if it helps reduce the need for prescription pain medicine. The device is designed to hold the bone together more securely, which may lead to less pain and faster recovery.
Naples, FloridaAges 19–80 - NCT06949826RecruitingPhase 4
Buprenorphine for pain after ankle fracture surgery
This trial tests if buprenorphine, a non-opioid pain medicine, works well for people who have not used opioids before. After ankle fracture surgery, you would get buprenorphine instead of stronger opioids to see if it controls pain just as well with fewer side effects.
St Louis, MissouriAges 18 years+ - NCT06387914Recruiting
Deep brain stimulation for chronic stroke pain
This trial tests whether deep brain stimulation (using a device implanted in the brain) can help relieve severe, long-lasting pain caused by a stroke. It is for people who have tried other treatments without success.
Oxford, OxfordshireAges 21 years+ - NCT07715591Recruiting
Relaxing breathing during awake cataract surgery
This study tests a special breathing and pain education program to help you stay calm and comfortable during cataract surgery while you are awake. It may reduce pain and anxiety without extra medicine.
Los Angeles, CaliforniaAges Any age - NCT07329309Recruiting
Breathing exercises for pain after cesarean
This study tests if a gentle breathing technique called Pranayama can help reduce pain after a planned cesarean. It compares the breathing exercise to usual care to see if it improves recovery.
Konya, KonyaAges 18–35 - NCT07242170Recruiting
Comparing nerve blocks for pain after knee replacement surgery
This trial tests if adding extra nerve blocks (sciatic, BiFeS, or IPACK) to the usual adductor canal block can reduce pain after total knee replacement. The goal is to find a better way to manage pain and improve recovery.
Erzincan, MerkezAges 18–75 - NCT07564427Recruiting
Electromagnetic therapy to reduce pain after hip replacement
This study tests whether a special electromagnetic therapy, added to standard recovery exercises, can reduce pain and improve movement after hip replacement surgery. The therapy is non-invasive and may help you regain function faster.
TaipeiAges 18–99 - NCT07414706RecruitingPhase 3
Numbing medicines for faster recovery after keyhole colorectal surgery
This study tests whether giving a numbing medicine (lidocaine) through an IV plus a local anesthetic at the surgery site can help you recover faster and with less pain after keyhole surgery for colorectal cancer.
AmiensAges 18 years+ - NCT07514637RecruitingPhase 2
Pain relief medication after pancreas surgery
This study tests a new drug called Anricfen (ariceptin) to help reduce pain and speed recovery after pancreas removal surgery. Participants receive injections for three days after surgery to see if the medication safely controls pain better than standard care.
NanjingAges 18–80 - NCT07453498Recruiting
Nerve block for pain after hip replacement
This study tests if a specific nerve block (the psoas sheath block) helps reduce pain after hip replacement surgery. If you are having a hip replacement, you may be able to join and get this extra pain relief.
GalwayAges 18 years+ - NCT07435675Recruiting
Nerve block to prevent agitation after ear surgery in children
This study tests if a nerve block behind the ear can help children ages 5–14 stay calm and comfortable after middle ear surgery. It may reduce confusion and restlessness when waking up from anesthesia.
Al Fayyum, Faiyum GovernorateAges 5–14 - NCT07221682RecruitingPhase 2/Phase 3
Comparing two nerve block methods for lower leg surgery
This study compares two ways of giving a nerve block (fascia iliaca block) to help with positioning for spinal anesthesia and pain relief after lower leg surgery. The goal is to see which method works better for making patients more comfortable.
Sāhīwāl, Punjab ProvinceAges 30–60 - NCT07218289Recruiting
Green light therapy for recovery after surgery
This study tests if exposing patients to green light after laparoscopic or robotic surgery can help reduce pain and improve recovery. You may be eligible if you are staying in the hospital for at least two days after your surgery.
Pittsburgh, PennsylvaniaAges 18 years+
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Common questions
- Are there clinical trials for post operative pain?
- Yes. Clin2 currently lists 186 recruiting post operative pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a post operative pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a post operative pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.