Clinical trials
Prediabetes clinical trials
Below are recruiting prediabetes clinical trials, each written for real people, not researchers. We’re tracking 140 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05866406Recruiting
Time-restricted eating to improve heart and sugar health
This study tests whether eating only within a set daily time window can improve cardiometabolic health (things like blood sugar and heart-related measures). You may be eligible if you have overweight and borderline/high-risk blood sugar but do not have diabetes and can follow the eating and testing rules.
CambridgeAges 25–75 - NCT05951660Recruiting
Study sexual side effects in schizophrenia with diabetes
This study looks at how sexual functioning is affected in people with schizophrenia, especially in those who also have diabetes or weight-related risk. It also examines how psychiatric medicines and diabetes/weight factors may be connected, which could help improve care for patients.
SlagelseAges 18 years+ - NCT06019624Recruiting
Fresh food boxes for diabetes or prediabetes
This study gives free fresh food boxes to people with diabetes or prediabetes who have had trouble getting enough food. The goal is to see if regular access to healthy food can help improve blood sugar control.
The Bronx, New YorkAges 18–75 - NCT06055036Recruiting
Stress reduction for heart health in Black men
This study looks at how reducing stress can improve cardiovascular health in Black men. It involves lifestyle changes and support to help lower your risk of heart disease.
Columbus, OhioAges 18 years+ - NCT06067139Recruiting
Sleep therapy to lower diabetes risk in prediabetes
This study tests if a sleep-focused therapy (cognitive behavioral therapy for insomnia, or CBT-I) can lower diabetes risk in people with prediabetes and insomnia. Participants will receive online therapy sessions and wear a monitor to track blood sugar and sleep.
Portland, OregonAges 22–79 - NCT06116149Recruiting
Healthy lifestyle program for new mothers in WIC clinics
This trial tests a lifestyle program for new mothers (up to 1 year after giving birth) who have obesity or had gestational diabetes. It runs in WIC clinics and aims to help you improve your health after pregnancy.
New Orleans, LouisianaAges 18 years+ - NCT06115876Recruiting
Kuwait diabetes long-term follow-up study
This study checks in on people with prediabetes or type 2 diabetes who were part of an earlier Kuwait diabetes study. It aims to understand how their condition has changed and what health care they may need.
Kuwait CityAges 21–75 - NCT06252038Recruiting
Rural Diabetes Prevention Program
This study tests a diabetes prevention program designed for people in rural Kansas. It helps those with pre-diabetes make healthy lifestyle changes to prevent or delay type 2 diabetes.
Kansas City, KansasAges 18 years+ - NCT06112418Recruiting
Personalized vs standard care to prevent heart attacks
This trial compares two ways to prevent heart attacks and strokes: one uses a special heart CT scan to guide care, the other uses standard risk factors like blood pressure and cholesterol. You may be eligible if you are older (men over 55, women over 65) and have diabetes, prediabetes, or metabolic syndrome.
Chandler, ArizonaAges 55 years+ - NCT06354088RecruitingPhase 1
Study of alpelisib for insulin resistance
This study tests a single dose of a drug called alpelisib (a PI3K inhibitor) to see how it affects insulin and blood sugar in people who are either insulin sensitive or insulin resistant. The goal is to understand why some people become resistant to insulin, which may help find new treatments for diabetes and related conditions.
New York, New YorkAges 18–70 - NCT06384313Recruiting
Butyrate supplement for preventing diabetes
This study tests if a special type of fat (butyrate) can help prevent diabetes in people who are overweight and have early signs of blood sugar problems. You would take a supplement for several weeks to see if it improves how your body handles sugar.
Maastricht, LimburgAges 20–70 - NCT06412536Recruiting
Heart, weight, and hormone trial screening survey
This trial is a quick survey to find out if you may be eligible for future studies on heart health, weight, or hormone-related conditions. It helps researchers match you with the right treatment options.
Brooklyn, New YorkAges 18 years+ - NCT06413069Recruiting
Can almonds help with prediabetes and fatty liver?
This study tests whether eating almonds daily can improve blood sugar and liver health in adults with prediabetes and non-alcoholic fatty liver disease (NAFLD). It might help if you have these conditions and want a natural way to support your health.
BerlinAges 35–70 - NCT06417840Recruiting
Testing a plant compound for blood sugar in pre-diabetes
This study tests whether a natural compound from plants can help lower blood sugar levels in people with pre-diabetes. It focuses on Asian Indian adults who are overweight and have slightly high blood sugar.
New DelhiAges 18–50 - NCT06424015Recruiting
Insulin pulses during fasting study
This study tests how insulin, given in pulses or continuously, affects your body during a fast. It may help researchers understand better ways to manage blood sugar in people with early blood sugar issues.
Rochester, MinnesotaAges 25–65 - NCT06424106Recruiting
Glucagon & fasting insulin in people without type 2 diabetes
This study looks at how glucagon affects insulin release and blood sugar in people who do not have type 2 diabetes. It may help us understand normal glucose control better.
Rochester, MinnesotaAges 25–65 - NCT06426277Recruiting
Brazilian diabetes prevention program
This study tests a program that helps people with prediabetes make healthy lifestyle changes to prevent type 2 diabetes. You would get support through your own device at home, with no need for in-person visits.
Goiânia, GoiásAges 18 years+ - NCT06440395Recruiting
Healthy eating and exercise program for prediabetes
This study tests a program called Small Steps for Big Changes, which helps people with prediabetes adopt healthier habits. The goal is to see if it works in community settings like YMCAs.
Edmonton, AlbertaAges 18 years+ - NCT06446531RecruitingPhase 1
Preventing diabetes progression in Hispanic adults
This trial tests if a medication can prevent or slow the progression from prediabetes to type 2 diabetes and reduce heart risk. It is for Hispanic adults who are overweight and have prediabetes.
San Antonio, TexasAges 18 years+ - NCT06481020Recruiting
Plant sterols for heart health in overweight adults
This study tests whether plant sterols (natural compounds found in plants) can help improve cholesterol and other heart health markers. If you are overweight and have high LDL cholesterol, you may be able to join this study to see if adding plant sterols to your diet helps.
ValenciaAges 18–80 - NCT06482944Recruiting
Whole-food diet program for families to prevent type 2 diabetes
This 12-week program helps parents with prediabetes and their children eat healthier whole foods based on U.S. dietary guidelines. The goal is to see if the program can lower the risk of developing type 2 diabetes in the family.
Nashville, TennesseeAges 6–59 - NCT06995378Recruiting
Study on prediabetes risk tools at UCLA
This study tests a tool that uses your electronic health records to identify older adults with prediabetes. It aims to help doctors better manage risk and prevent diabetes.
Los Angeles, CaliforniaAges 65 years+ - NCT06507722Recruiting
Night Owl Metabolism Study
This study from Johns Hopkins looks at how your body's metabolism works when you're an overweight teen or young adult who sleeps enough. It aims to learn more about your 'night owl' internal clock and how it affects your health.
Baltimore, MarylandAges 18–23 - NCT06580964Recruiting
Heat and exercise therapy for aging adults with prediabetes
This study tests whether combining exercise with heat therapy can help older adults with prediabetes improve their health. It may offer a new way to manage blood sugar without medication.
Lubbock, TexasAges 50 years+
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Common questions
- Are there clinical trials for prediabetes?
- Yes. Clin2 currently lists 140 recruiting prediabetes studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a prediabetes trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a prediabetes trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.