Clinical trials
Preserved Ejection Fraction clinical trials
Below are recruiting preserved ejection fraction clinical trials, each written for real people, not researchers. We’re tracking 128 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07401771Recruiting
Exercise heart MRI in heart failure with preserved pumping strength
This study uses a special exercise MRI to see how the heart works during activity in people with a type of heart failure where the heart's pumping strength is normal. It also includes people with shortness of breath from other causes and healthy volunteers to compare results.
Rochester, MinnesotaAges 18–80 - NCT07214376Recruiting
Nerve ablation for pulmonary hypertension from left heart disease
This trial tests a device that uses a catheter to deliver energy to nerves around the pulmonary arteries, aiming to reduce high blood pressure in the lungs caused by left heart failure. It is for people with ongoing heart failure symptoms despite optimal medications.
Tucson, ArizonaAges 18–85 - NCT07123779RecruitingPhase 1/Phase 2
Study of HS235 in obese patients with pulmonary hypertension and heart failure
This trial tests an investigational drug called HS235 in people who have both obesity (BMI 30-50) and a specific type of heart failure with preserved pumping function, along with high blood pressure in the lungs. The goal is to see if the drug can improve symptoms and quality of life.
Greenville, South CarolinaAges 18 years+ - NCT06337812Recruiting
Fiber supplement study for heart failure and diabetes
This study tests whether adding a daily fiber supplement can improve health in people with heart failure and type 2 diabetes. Participants take the supplement for several weeks to see if it helps manage symptoms and blood sugar.
Ann Arbor, MichiganAges 18 years+ - NCT05383287Recruiting
Study of heart failure with preserved pumping function
This study looks at the different features and patterns of people with heart failure where the heart’s pumping strength is preserved. It may help doctors better understand your type of heart failure and tailor care.
ManchesterAges 18 years+ - NCT05174351Recruiting
Stopping beta-blockers in heart failure with preserved pumping
This study checks whether safely stopping beta-blocker medicine is possible in some people with heart failure with preserved pumping (EF ≥50%). It may help by testing whether reducing the medication is safe and workable for certain patients.
Farmington, ConnecticutAges 50–80 - NCT02901184RecruitingPhase 3
Spironolactone start study for heart failure with preserved pumping
This trial tests whether starting spironolactone helps people with heart failure symptoms when the heart pumps “preserved” (not severely reduced). Participants are assigned to start spironolactone or usual care so researchers can see if it improves outcomes.
Alexander City, AlabamaAges 50–99 - NCT06196086Recruiting
Measuring heart stiffness in heart failure with normal pumping
This study uses a special ultrasound technique to check how stiff the heart muscle is in people with heart failure who have a normal pumping ability (HFpEF). It aims to better understand heart stiffness to help diagnose and manage this condition.
Jinan, ShandongAges 18–80 - NCT06377761Recruiting
Qishen granules for heart failure with preserved pumping function
This trial tests a Chinese herbal medicine called Qishen Granules for people with heart failure who still have a normal pumping ability (ejection fraction 50% or higher). It may help reduce symptoms and improve heart function.
Guangzhou, GuangdongAges 18–85 - NCT05441839Recruiting
Heart failure with preserved pumping function study in the UK
This trial studies people who have heart failure symptoms but whose heart pumping strength is largely preserved. It aims to better understand this specific type of heart failure and how best to treat or evaluate it.
AbercynonAges 18 years+ - NCT07634640RecruitingEarly Phase 1
Testing an Inflammation Treatment for Heart Failure
This early-stage trial tests a new approach to treat heart failure with preserved ejection fraction (HFpEF)—a type of heart failure where the heart's pumping strength is normal, but it doesn't relax properly. Researchers believe inflammation plays a role and want to see if targeting it can help patients feel better and function more easily.
Gainesville, FloridaAges 18–85 - NCT05097898Recruiting
Check fluid buildup in heart failure with normal pumping
This study evaluates how well doctors can assess “fluid congestion” in people with chronic heart failure where the heart’s squeezing is still preserved. It may help improve how patients are monitored during hospital visits.
Vandœuvre-lès-NancyAges 18 years+ - NCT05784753Recruiting
Exercise coaching for adults with heart failure and preserved heart strength
This study tests an exercise-focused program (including coaching/support) for adults with heart failure where the pumping strength is preserved. It may help improve exercise ability and daily function while monitoring safety.
Detroit, MichiganAges 18 years+ - NCT06388226Recruiting
Leg heat therapy for heart failure with preserved pumping ability
This study tests if applying heat to your legs can improve symptoms and heart function in people with a type of heart failure where the heart pumps normally but doesn't relax properly. It aims to find a simple, drug-free way to help you feel better.
Indianapolis, IndianaAges 18 years+ - NCT05525663Recruiting
Rehab for older adults after heart failure with strong pumping
This trial studies whether a physical rehabilitation program helps older adults recover and function better after a recent hospital stay for heart failure when the heart’s pumping strength is preserved. It may help you regain walking ability and daily independence after your episode.
Winston-Salem, North CarolinaAges 60 years+ - NCT07219511RecruitingPhase 1
Safety study of VS-041 for heart failure with preserved pumping strength
This trial tests an investigational drug called VS-041 to see if it's safe and helps people with a type of heart failure where the heart pumps well but doesn't relax properly (HFpEF). It may be an option if you are 50 or older and have stable heart failure symptoms.
Little Rock, ArkansasAges 50 years+ - NCT06560762RecruitingPhase 1
Study of a new drug for heart failure with preserved pumping ability
This trial tests an investigational drug for people with a type of heart failure where the heart pumps normally but is stiff. The goal is to see if the drug can improve symptoms and quality of life.
Chicago, IllinoisAges 18 years+ - NCT05715697Recruiting
Kidney artery treatment for heart failure with normal heart pumping
This study tests whether renal denervation (a procedure to reduce overactive signals in kidney arteries) can help people who have heart failure but keep a normal pumping ability and still have high blood pressure. It aims to improve blood-pressure control and heart function in this specific group.
Ürümqi, XinjiangAges 21–80 - NCT07326605Enrolling by invitation
Heart MRI study for heart failure with preserved pumping function
This trial uses a special heart MRI to create pressure-volume loops in people with heart failure who have a normal pumping strength (ejection fraction of 50% or higher). It aims to better understand heart function and could help guide future treatments. You may qualify if you have heart failure symptoms and specific heart structure or function changes.
Ages 18 years+ - NCT07269717RecruitingPhase 2
Testing HRS-1893 for heart failure with preserved ejection fraction
This trial tests a new drug called HRS-1893 for people with heart failure with preserved ejection fraction (HFpEF). It aims to see if the drug can improve symptoms and quality of life.
Shanghai, Shanghai MunicipalityAges 40 years+ - NCT06670001Recruiting
Increasing daily steps in heart failure with preserved ejection fraction
This study tests if simple rewards and reminders on a smartphone can help people with a certain type of heart failure (HFpEF) become more physically active. The goal is to see if increasing daily steps improves their health and well-being.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06685237Recruiting
Copenhagen heart failure with preserved pumping study
This study is for people in the Capital Region of Denmark who are at least 50 years old and have certain health conditions that put them at risk for a type of heart failure where the heart pumps normally but doesn't relax properly. The study aims to find and help people before heart failure develops.
HellerupAges 50–89 - NCT04237701Recruiting
Tracking heart failure in real time at Yale
This trial looks at how people with heart failure are doing using real-time monitoring across the Yale New Haven Health System. It may help improve care by spotting problems sooner and tracking treatment effects.
New Haven, ConnecticutAges 18 years+ - NCT05030987Recruiting
Renal denervation for heart failure with preserved heart strength
This trial studies whether a procedure that calms overactive kidney nerves (renal denervation) can improve symptoms and heart function in people with heart failure with preserved ejection fraction. It also checks that the kidney arteries are suitable and that your blood pressure and heart pressure measurements meet the study targets.
Halle, Saxony-AnhaltAges 18–80
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Common questions
- Are there clinical trials for preserved ejection fraction?
- Yes. Clin2 currently lists 128 recruiting preserved ejection fraction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a preserved ejection fraction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a preserved ejection fraction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Heart Failure With Preserved Ejection Fraction
- Heart Failure With Reduced Ejection Fraction
- Heart Failure With Mildly Reduced Ejection Fraction
- Heart Failure With Mid Range Ejection Fraction
- Heart Failure With Normal Ejection Fraction
- Chronic Heart Failure With Reduced Ejection Fraction
- Preserved Ratio Impaired Spirometry (PRISM)
- Preserved Ratio Impaired Spirometry
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.