Clinical trials
Preserved Ejection Fraction clinical trials
Below are recruiting preserved ejection fraction clinical trials, each written for real people, not researchers. We’re tracking 120 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06826963Recruiting
Eccentric exercise for older adults with heart failure and muscle loss
This study tests whether a special type of exercise (eccentric, or lengthening, exercises) can help older adults with heart failure who also have muscle loss. It aims to see if the exercise is safe and improves strength and function.
Verona, VeronaAges 65–85 - NCT07298993Enrolling by invitationPhase 4
Can older adults with heart failure safely stop beta-blockers?
This trial tests whether it is safe to gradually stop beta-blocker medication in older adults with heart failure with preserved ejection fraction (a type of heart failure where the heart pumps normally but is stiff). It aims to improve quality of life by reducing unnecessary medications.
Pleasanton, CaliforniaAges 60 years+ - NCT07269717RecruitingPhase 2
Testing HRS-1893 for heart failure with preserved ejection fraction
This trial tests a new drug called HRS-1893 for people with heart failure with preserved ejection fraction (HFpEF). It aims to see if the drug can improve symptoms and quality of life.
Shanghai, Shanghai MunicipalityAges 40 years+ - NCT07272902Recruiting
Atrial fibrillation treatment: Ablation vs. medication
This trial compares two ways to treat atrial fibrillation in people with heart failure where the heart's pumping strength is still normal. You'll either get a procedure called ablation to restore normal rhythm or medication to control your heart rate. The goal is to see which approach works better for people like you.
Halifax, Nova ScotiaAges 18 years+ - NCT05582044Recruiting
Exercise using leg suction for heart failure with preserved function
This study tests whether a specific lower-body exercise method using negative pressure (leg suction) can improve symptoms and heart-related function in people with heart failure with preserved ejection fraction (HFpEF). You may also be offered screening if you are a healthy person, to compare results.
Kelowna, British ColumbiaAges 40 years+ - NCT06560762RecruitingPhase 1
Study of a new drug for heart failure with preserved pumping ability
This trial tests an investigational drug for people with a type of heart failure where the heart pumps normally but is stiff. The goal is to see if the drug can improve symptoms and quality of life.
Chicago, IllinoisAges 18 years+ - NCT07219511RecruitingPhase 1
Safety study of VS-041 for heart failure with preserved pumping strength
This trial tests an investigational drug called VS-041 to see if it's safe and helps people with a type of heart failure where the heart pumps well but doesn't relax properly (HFpEF). It may be an option if you are 50 or older and have stable heart failure symptoms.
Little Rock, ArkansasAges 50 years+ - NCT07214376Recruiting
Nerve ablation for pulmonary hypertension from left heart disease
This trial tests a device that uses a catheter to deliver energy to nerves around the pulmonary arteries, aiming to reduce high blood pressure in the lungs caused by left heart failure. It is for people with ongoing heart failure symptoms despite optimal medications.
Tucson, ArizonaAges 18–85 - NCT07178145RecruitingPhase 4
Heart fat and heart failure with preserved pumping ability study
This study looks at fat around the heart in people with heart failure where the heart still pumps normally. It uses MRI scans to understand this fat better, and may help find new treatments.
Charlottesville, VirginiaAges 18–90 - NCT05441839Recruiting
Heart failure with preserved pumping function study in the UK
This trial studies people who have heart failure symptoms but whose heart pumping strength is largely preserved. It aims to better understand this specific type of heart failure and how best to treat or evaluate it.
AbercynonAges 18 years+ - NCT07123779RecruitingPhase 1/Phase 2
Study of a new drug for heart failure with pulmonary hypertension
This study tests an investigational drug (HS235) for people who have both heart failure with preserved ejection fraction and a type of pulmonary hypertension that can happen with it. The goal is to see if the drug can improve symptoms and quality of life.
Kansas City, MissouriAges 18 years+ - NCT07057466Recruiting
Checking heart scans with artificial intelligence
This study uses AI to read electrocardiograms (heart rhythm tests) to see if they can detect certain heart structure problems earlier. If you are already scheduled for an echocardiogram (heart ultrasound), your data may be used to help improve detection.
BristolAges 18–90 - NCT07037459RecruitingPhase 3
A study of a new drug for heart failure with obesity
This trial tests a medication called maridebart cafraglutide for people with heart failure (where the heart doesn't pump as well as it should) and obesity. The goal is to see if it can help improve symptoms and outcomes.
Birmingham, AlabamaAges 18–99 - NCT06937320Enrolling by invitationPhase 2
Testing ketone supplements for heart failure with preserved ejection fraction (HFpEF)
This study tests whether a special dietary supplement (ketone esters) can improve exercise ability and heart function in people with a type of heart failure where the heart pumps well but is stiff (HFpEF). You might join if you have stable symptoms, an ejection fraction of 50% or higher, and signs of fluid buildup in the heart.
Durham, North CarolinaAges 18 years+ - NCT06909682Recruiting
AI monitoring with wearables for chronic heart failure
This trial tests an AI system that uses wearable devices and mini-invasive tools to monitor people with chronic heart failure. The goal is to detect changes early and help manage the condition at home.
SalernoAges 19 years+ - NCT06833138Recruiting
Pacing vs medication for heart rate control in AF with heart failure
This trial tests whether a procedure that regulates your heart rhythm (pacing) works better than medication for people who have permanent atrial fibrillation, heart failure with a normal pumping strength, and were hospitalized for heart failure in the past year.
BesançonAges 18 years+ - NCT06337812Recruiting
Fiber supplement study for heart failure and diabetes
This study tests whether adding a daily fiber supplement can improve health in people with heart failure and type 2 diabetes. Participants take the supplement for several weeks to see if it helps manage symptoms and blood sugar.
Ann Arbor, MichiganAges 18 years+ - NCT06763549Enrolling by invitation
AI-powered wearable patch for heart and lung monitoring
This study tests an AI-powered wearable patch (the COR ECG) to see if it can better track heart and lung health. It may help doctors find problems earlier without needing bulky equipment.
Melbourne, FloridaAges 18 years+ - NCT06768437Recruiting
Heart fat and preserved ejection fraction heart failure trial
This study looks at whether fat around the heart affects a type of heart failure where the heart pumps well but is stiff (HFpEF). You may be able to join if you have this condition, are 18 or older, and can understand English.
Leicester, LeicestershireAges 18 years+ - NCT06699056Recruiting
AI heart monitor study for ejection fraction
This study uses an AI-powered wearable monitor to check how well your heart pumps blood (ejection fraction) from a simple EKG recording. It may help doctors quickly assess heart function without extra tests.
Orange, CaliforniaAges 18 years+ - NCT06670001Recruiting
Increasing daily steps in heart failure with preserved ejection fraction
This study tests if simple rewards and reminders on a smartphone can help people with a certain type of heart failure (HFpEF) become more physically active. The goal is to see if increasing daily steps improves their health and well-being.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06652763Recruiting
MRI scan for heart failure with normal pumping strength
This study uses a special MRI scan with a natural contrast agent (manganese) to look at how well the heart muscle works in people with heart failure who still have normal pumping strength. The goal is to learn more about why this type of heart failure happens.
LeicesterAges 18 years+ - NCT06517186Recruiting
Heart failure study with preserved pumping function
This study looks at how the heart muscle works in people with a type of heart failure where the heart pumps normally but doesn't fill properly. It aims to understand the cause better, which could lead to new treatments.
Chicago, IllinoisAges 30 years+ - NCT06388226Recruiting
Leg heat therapy for heart failure with preserved pumping ability
This study tests if applying heat to your legs can improve symptoms and heart function in people with a type of heart failure where the heart pumps normally but doesn't relax properly. It aims to find a simple, drug-free way to help you feel better.
Indianapolis, IndianaAges 18 years+
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Common questions
- Are there clinical trials for preserved ejection fraction?
- Yes. Clin2 currently lists 120 recruiting preserved ejection fraction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a preserved ejection fraction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a preserved ejection fraction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Heart Failure With Preserved Ejection Fraction
- Heart Failure With Reduced Ejection Fraction
- Heart Failure With Mildly Reduced Ejection Fraction
- Heart Failure With Mid Range Ejection Fraction
- Heart Failure With Normal Ejection Fraction
- Chronic Heart Failure With Reduced Ejection Fraction
- Preserved Ratio Impaired Spirometry (PRISM)
- Preserved Ratio Impaired Spirometry
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.