Clinical trials
Prostate Cancer Surgery clinical trials
Below are recruiting prostate cancer surgery clinical trials, each written for real people, not researchers. We’re tracking 449 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04794777RecruitingPhase 3
Tests targeted scans and rescue radiation for returning prostate cancer
This trial studies whether a targeted scan (PSMA PET/CT) can help doctors choose the best “salvage” radiation treatment when prostate cancer comes back by PSA blood tests after surgery. It may help some people avoid under- or over-treating the areas where the cancer is returning.
Gothenburg, GöteborgAges 18 years+ - NCT04946370RecruitingPhase 1/Phase 2
Pembrolizumab plus prostate cancer drug, with or without radiation
This early-phase trial tests pembrolizumab (an immune therapy) plus an androgen-receptor–blocking prostate cancer drug, and possibly a targeted radiation treatment. It’s for men with prostate cancer that has spread and keeps worsening despite standard hormone therapy, aiming to shrink tumors and improve control of the disease.
Boston, MassachusettsAges 18 years+ - NCT04947254RecruitingPhase 2
Add niraparib to hormone therapy after prostate radiation
This Phase 2 trial tests whether adding niraparib to standard hormone therapy (androgen ablation) after radiation works better for men with high-risk, localized or locally advanced prostate cancer. It may help control the cancer for longer, while also collecting extra tissue and blood to study why the treatment works or doesn’t.
Houston, TexasAges 18 years+ - NCT05019846RecruitingPhase 3
Radiation alone versus radiation plus hormone therapy for prostate cancer
This Phase 3 trial compares two treatment approaches: stereotactic radiation therapy by itself versus the same radiation plus hormone therapy (ADT). It aims to see which plan works better for men with higher-risk prostate cancer without spread to lymph nodes or distant sites.
Brescia, BSAges 18–80 - NCT05022914Recruiting
PSMA PET/CT scan for PSA relapse after prostate surgery
This trial looks at using a PSMA PET/CT scan to better re-check cancer activity in men whose PSA has started rising after prostate removal. If you qualify, the scan may help doctors choose the next best treatment step.
FlorenceAges 18 years+ - NCT05045066RecruitingEarly Phase 1
Vitamin D treatment study for Black men with prostate cancer
This early-phase study looks at how vitamin D replacement affects the immune system in Black/African American men with prostate cancer. It’s testing whether bringing vitamin D levels into a healthier range changes immune signals that may matter for cancer health.
Scottsdale, ArizonaAges 18 years+ - NCT05155501Recruiting
Surgery planning approaches for localized prostate cancer
This study compares different approaches used during prostate cancer surgery for men whose cancer is only in the prostate. It may help doctors choose the safest and most effective surgical plan for your situation.
Duarte, CaliforniaAges 40–80 - NCT05168618RecruitingPhase 2
Cabozantinib and atezolizumab for advanced prostate cancer
This Phase 2 trial tests cabozantinib plus atezolizumab in people with metastatic prostate cancer that keeps growing despite hormone-blocking therapy and newer hormone drugs. It may help shrink tumors and control the disease, especially in advanced cases where options are limited.
Salt Lake City, UtahAges 18 years+ - NCT05241236Recruiting
Laser ablation guided by MRI and ultrasound for prostate cancer
This trial looks at a treatment that uses MRI and ultrasound to guide a laser to destroy prostate cancer. It may help men with low- or intermediate-risk prostate cancer who do not have spread beyond the prostate.
Miami Lakes, FloridaAges 50 years+ - NCT05346848RecruitingPhase 2
Darolutamide plus radiation for intermediate-risk prostate cancer
This trial tests whether adding darolutamide to standard radiation can better control intermediate-risk prostate cancer. It includes men whose cancer has spread nowhere else and who are newly diagnosed with “unfavorable intermediate risk” or progress to that risk group.
AvignonAges 18 years+ - NCT05350475Recruiting
Prostate cancer radiotherapy with protons versus photons
This trial compares two types of radiation—protons versus photons—for high-risk localized prostate cancer. It aims to see which option works well while causing fewer problems for nearby organs.
Copenhagen, Capital RegionAges 18 years+ - NCT05352178RecruitingPhase 3
Targeted treatment for few-spread prostate cancer spots
This Phase 3 trial tests whether treating only a small number of prostate cancer metastases can help people with “oligorecurrent” (limited repeat) prostate cancer. It may reduce cancer activity while avoiding broader whole-body treatment for some patients.
LeuvenAges 18 years+ - NCT05413850RecruitingPhase 1/Phase 2
Lu-177 PSMA drug study for advanced prostate cancer
This early-stage study tests a radioactive prostate cancer medicine that targets PSMA (a protein on prostate cancer cells). It aims to see how well the treatment works and how safe it is for men whose cancer has spread and shows PSMA on a scan.
Miami, FloridaAges 18 years+ - NCT05448547RecruitingPhase 3
Tested curative vs conservative treatment for older men with high-risk prostate cancer
This Phase 3 study compares an immediate curative treatment plan versus a more conservative approach in men age 75 and older with newly diagnosed, high-risk prostate cancer. The goal is to see which strategy controls the cancer while better protecting quality of life.
CopenhagenAges 75 years+ - NCT05454488RecruitingPhase 2
Study focal freezing for intermediate-risk prostate cancer
This trial tests whether freezing only the cancer area in the prostate (focal cryotherapy) can control intermediate-risk prostate cancer. It aims to limit treatment to one tumor focus while closely checking results with targeted and follow-up testing.
Houston, TexasAges 18 years+ - NCT05521412RecruitingPhase 1/Phase 2
PSMA-targeted radioligand for advanced prostate cancer
This Phase 1/2 trial tests a PSMA-targeted radioligand treatment (a drug that delivers radiation to prostate cancer cells) in men with metastatic castration-resistant prostate cancer that has gotten worse despite standard hormone therapies. It’s designed to see how the treatment works and whether it can help shrink or control cancer, while also studying safety and dosing.
Melbourne, VictoriaAges 18 years+ - NCT05557604RecruitingPhase 2
Tested a targeted prostate cancer radiation plan for higher-risk patients
This Phase 2 trial studies whether a specific radiation approach (including detailed targeting and tracking) can work better for men with intermediate-risk to high-risk prostate cancer. You may be eligible if your scans show no spread beyond the prostate area and you can safely complete the required imaging and treatments.
Rome, LazioAges 18–90 - NCT05574244Recruiting
Partial vs complete prostate surgery to preserve ejaculation
This trial compares two surgical approaches for men with benign prostate enlargement (BPH): one that aims to preserve ejaculation and one that removes more tissue. It looks at how well you recover urinary function and sexual outcomes after surgery.
Aix-en-ProvenceAges 40 years+ - NCT05590624Recruiting
Mediterranean diet study for men on prostate cancer active surveillance
This trial studies how different controlled versions of a Mediterranean-style diet may affect prostate cancer-related metabolism in men choosing active surveillance. It may help participants understand whether diet changes influence markers linked to prostate cancer activity, while keeping them on a monitored care plan.
Cleveland, OhioAges 18 years+ - NCT05698576Recruiting
Laser treatment through the skin for men with prostate cancer
This trial tests a laser procedure done through the skin between the scrotum and anus, guided by MRI and ultrasound, for men with certain prostate cancer types. It aims to heat and treat prostate cancer while checking safety and outcomes over follow-up visits.
Hialeah, FloridaAges 50–80 - NCT05710380Recruiting
MRI scans to guide biopsy for prostate cancer diagnosis
This study tests whether special MRI “risk maps” can help doctors better identify suspicious areas in the prostate during diagnosis. If you’re having an MRI followed by an MRI-guided biopsy, this may help improve how the biopsy targets areas of concern.
Chicago, IllinoisAges 18 years+ - NCT05714774Recruiting
Ultrasound analysis methods during HIFU prostate cancer treatment
This study compares different ways to analyze ultrasound images in real time while treating localized prostate cancer with HIFU (a focused ultrasound treatment). It aims to improve how safely and accurately the treatment is monitored.
LyonAges 50 years+ - NCT05740956RecruitingPhase 1
Drug study for cancers with HRR gene or HRD changes
This Phase 1 study tests HS-10502 in people with advanced solid tumors that have certain DNA repair problems (HRR or HRD). It may help by finding a safe dose and seeing whether the drug can shrink tumors in cancers that have specific genetic features.
Beijing, Beijing MunicipalityAges 18–75 - NCT05754580Recruiting
Boost radiation for intermediate or higher-risk prostate cancer
This study tests a stronger, focused radiation plan for intermediate to higher-risk prostate cancer. It combines a high-dose internal radiation “boost” with external radiation to try to improve cancer control while keeping side effects manageable.
Omaha, NebraskaAges 19 years+
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Common questions
- Are there clinical trials for prostate cancer surgery?
- Yes. Clin2 currently lists 449 recruiting prostate cancer surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a prostate cancer surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a prostate cancer surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.