Clinical trials
Pulmonary Hypertension clinical trials
Below are recruiting pulmonary hypertension clinical trials, each written for real people, not researchers. We’re tracking 247 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07473700RecruitingPhase 2
Study of TX000045 for lung scarring and high blood pressure in the lungs
This trial tests a new medicine called TX000045 for people who have both lung scarring (interstitial lung disease) and high blood pressure in the lungs (pulmonary hypertension). It aims to see if the drug can help improve breathing and daily function.
Phoenix, ArizonaAges 18–80 - NCT05719415Recruiting
Testing balloon treatment effects on lung blood-vessel surface area
This study looks at how a procedure called balloon pulmonary angioplasty changes measurements in lung blood vessels in people with chronic thromboembolic pulmonary hypertension. It may help doctors understand what changes the treatment makes and why.
Montreal, QuebecAges 18–75 - NCT07822997Recruiting
Quality of Life Questionnaire for Pulmonary Hypertension in Brazil
This study is testing a questionnaire (EMPHASIS-10) to measure quality of life in people with pulmonary hypertension. The goal is to adapt it for Brazilian Portuguese speakers so doctors can better understand how the disease affects daily life.
Porto AlegreAges 18 years+ - NCT07759804RecruitingPhase 4
Switching from selexipag to inhaled treprostinil for pulmonary arterial hypertension
This study tests whether switching from the oral medicine selexipag to an inhaled medicine called treprostinil can improve symptoms or side effects in people with pulmonary arterial hypertension (PAH). It may be an option if you are not getting enough benefit or are having trouble tolerating selexipag.
Columbus, GeorgiaAges 18–80 - NCT07646860RecruitingPhase 2
Sotatercept for Japanese Children With Pulmonary Arterial Hypertension
This study tests a new medicine called sotatercept in Japanese children who have pulmonary arterial hypertension (PAH)—a condition where blood vessels in the lungs become narrow and stiff, making it harder for the heart to pump blood through them. The medicine may help improve how well their hearts and lungs work together.
Izumi, OsakaAges 1–17 - NCT06703801Enrolling by invitation
Tracking pulmonary hypertension and quality of life
This study is tracking people with pulmonary hypertension (high blood pressure in the lungs) over time to see how their condition and quality of life change. By joining, you help doctors better understand the disease and improve care for others like you.
Hong KongAges 19 years+ - NCT06481852RecruitingPhase 1
Gut bacteria transplant for pulmonary arterial hypertension
This trial tests whether a special combination of antibiotics, fecal transplant (gut bacteria from healthy donors), and a fiber supplement can help people with pulmonary arterial hypertension (PAH). It aims to see if improving gut health can improve PAH symptoms and overall well-being.
Minneapolis, MinnesotaAges 18–75 - NCT05587712RecruitingPhase 2
Sotatercept trial for children with pulmonary arterial hypertension
This Phase 2 trial tests sotatercept, a medicine that targets the blood-vessel changes in pulmonary arterial hypertension (PAH), in children. It may help improve how well the heart and lungs work by changing the underlying disease process.
Los Angeles, CaliforniaAges 1–17 - NCT07558460Enrolling by invitation
Virtual Reality Training for Pulmonary Hypertension Patients
This study tests whether using virtual reality can help people with pulmonary hypertension (a condition affecting blood vessels in the lungs) improve their exercise ability and quality of life. You'll use VR while doing gentle physical activities to see if it's helpful and safe.
Istanbul, FatihAges 18–65 - NCT06917196Recruiting
Inhaled imatinib for advanced lung disease before or after transplant
This trial tests whether a special inhaled form of the medicine imatinib can help people with advanced lung scarring or high blood pressure in the lungs. It is designed for those who are on the path to a lung transplant or already received one.
Pavia, PaviaAges 18 years+ - NCT04778046RecruitingPhase 2
Study lung pressure treatment for people waiting for transplant
This Phase 2 trial is for adults with pulmonary hypertension who are on the lung transplant waiting list at Duke. It aims to test whether the study treatment can improve lung pressure and related health outcomes, while using things like MRI to monitor changes.
Durham, North CarolinaAges 18 years+ - NCT05746039RecruitingPhase 1/Phase 2
Testing semaglutide for advanced lung disease
This study checks whether semaglutide is safe and feasible for people with advanced lung diseases and higher body weight. It may help by testing a structured treatment approach, but it includes several health and safety limits.
Philadelphia, PennsylvaniaAges 18–80 - NCT02966665RecruitingPhase 1
Testing blood vessel function in people of different health conditions
This early study measures how well your blood vessels work using tests that may include MRI. It compares healthy people with people who have conditions like COPD, pulmonary arterial hypertension, heart failure, or high blood pressure, to better understand “vascular function” in health and disease.
Salt Lake City, UtahAges 18 years+ - NCT06495970Recruiting
Pulmonary artery denervation for heart failure with lung hypertension
This trial tests a procedure called pulmonary artery denervation (PADN) for people with heart failure and a certain type of high blood pressure in the lungs (pulmonary hypertension Group 2). The goal is to see if using a special device called the Gradient Denervation System can help control the high pressures and improve your symptoms.
BadalonaAges 22–85 - NCT07850934Recruiting
Melatonin for high blood pressure in the lungs of newborns
This trial tests whether giving melatonin to full-term newborns with high blood pressure in their lungs (pulmonary hypertension) can help improve their breathing and oxygen levels. It may offer a new treatment option for babies with this condition.
Cairo, AbbassiaAges Any age - NCT06526468Recruiting
AI study for diagnosing blood clots in lungs
This study uses artificial intelligence to look at imaging scans from people who might have a pulmonary embolism (a blood clot in the lungs). It aims to help doctors better diagnose and treat this condition.
BeijingAges 14 years+ - NCT06052072Enrolling by invitation
Heart failure trial testing nerve treatment for lung pressure
This trial tests a new treatment that uses a device to calm overactive nerves in the lung's blood vessels. It is for heart failure patients who also have high blood pressure in their lungs, to see if it can help them breathe easier and feel better.
Chicago, IllinoisAges 22–85 - NCT05798923RecruitingPhase 2
Study of a new drug for pulmonary hypertension with lung disease
This trial tests an investigational drug called LAM-001 for people who have pulmonary hypertension (high blood pressure in the lungs) along with a type of lung disease called interstitial lung disease. The drug may help improve symptoms and daily function. This study will see if the drug is safe and helpful for this condition.
Tucson, ArizonaAges 18–85 - NCT07234032RecruitingPhase 3
Long-term follow-up study of TPIP for PH-ILD
This trial is a long-term follow-up study for people who already completed a previous study of an inhaled treprostinil medication (TPIP) for pulmonary hypertension caused by interstitial lung disease (PH-ILD). It tests whether continued treatment with TPIP is safe and effective over a longer period.
Naples, FloridaAges 18 years+ - NCT07179380RecruitingPhase 3
Inhaled treprostinil for pulmonary hypertension related to interstitial lung disease
This study tests an inhaled powder medication called TPIP (treprostinil palmitil inhalation powder) to see if it can improve symptoms and exercise ability in people who have both interstitial lung disease and pulmonary hypertension. The study will compare TPIP against a placebo (a dummy treatment without the active drug) to understand how well it works and if it is safe.
Phoenix, ArizonaAges 18 years+ - NCT07123779RecruitingPhase 1/Phase 2
Study of a new drug for heart failure with pulmonary hypertension
This study tests an investigational drug (HS235) for people who have both heart failure with preserved ejection fraction and a type of pulmonary hypertension that can happen with it. The goal is to see if the drug can improve symptoms and quality of life.
Kansas City, MissouriAges 18 years+ - NCT07079592Recruiting
Detecting pulmonary hypertension with AI and EKGs
This trial uses an artificial intelligence program to analyze a standard EKG to see if it can detect pulmonary hypertension (high blood pressure in the lungs). It might help find the condition earlier and without invasive tests.
TaipeiAges 50–85 - NCT01501838Recruiting
Registry study for adults with a specific type of pulmonary hypertension
This study is a hospital registry that collects information about adults diagnosed with pulmonary arterial hypertension (a specific type of high blood pressure in the lungs). It helps doctors better understand patients over time and improve care.
Buenos Aires, Buenos AiresAges 17 years+ - NCT05665556Recruiting
Registry for pulmonary hypertension in connective tissue disease
This trial is a registry that collects health information from people with certain types of pulmonary hypertension linked to connective tissue diseases. It helps doctors understand patterns of disease and outcomes, which can guide future care and studies.
Mexico CityAges 18 years+
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Common questions
- Are there clinical trials for pulmonary hypertension?
- Yes. Clin2 currently lists 247 recruiting pulmonary hypertension studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pulmonary hypertension trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pulmonary hypertension trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Pulmonary Arterial Hypertension
- Chronic Thromboembolic Pulmonary Hypertension
- Pulmonary Artery Hypertension
- Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
- Idiopathic Pulmonary Arterial Hypertension
- Pulmonary Hypertension Due to Lung Diseases and Hypoxia
- Pulmonary Hypertension (Diagnosis)
- Pulmonary Hypertension Due to Left Heart Disease
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.