Clinical trials
Rectal Cancer Patients clinical trials
Below are recruiting rectal cancer patients clinical trials, each written for real people, not researchers. We’re tracking 365 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06272461Recruiting
Comparing lidocaine vs. ketamine for colorectal surgery pain
This trial compares two pain-relief medicines (lidocaine vs. ketamine) given through an IV during open colorectal surgery. It aims to find which one works better to reduce pain after surgery.
NabeulAges 18–90 - NCT06519006Recruiting
Pelvic floor exercises after rectal surgery
This trial tests whether doing pelvic floor exercises after a type of rectal surgery called 'low anterior resection' can help prevent bowel problems known as Low Anterior Resection Syndrome (LARS). It may help you maintain better bowel control after surgery.
Banská BystricaAges 19 years+ - NCT06542588RecruitingPhase 2
Short radiation plus chemo and immunotherapy for rectal cancer
This trial tests a combination of short-course radiation, chemotherapy, and two types of immunotherapy (HLX07 and Serplulimab) before surgery for advanced rectal cancer. It aims to see if this approach helps shrink tumors and improve outcomes.
Wuhan, HubeiAges 18–75 - NCT06628674Recruiting
Online videos for recovery after rectal cancer surgery
This trial tests if watching online interactive videos can help people who have had surgery for stage I to III rectal cancer deal with common bowel problems after treatment. Your participation could lead to better support tools for other patients.
Taoyuan, 中和區Ages 20 years+ - NCT06923345RecruitingPhase 2
Modified long-course radiation and chemo with immunotherapy for rectal cancer
This trial tests a treatment plan involving radiation, chemotherapy, and an immunotherapy drug (a PD-1 inhibitor) for people with a specific type of high-risk rectal cancer. The goal is to see if this combination helps shrink the tumor before surgery.
Guangzhou, GuangdongAges 18–75 - NCT07085169RecruitingPhase 2
Low-dose chemo combo for advanced colorectal cancer
This trial tests a lower dose of a chemotherapy pill (trifluridine/tipiracil) combined with bevacizumab for advanced colorectal cancer that has not responded to at least two prior treatments. The goal is to see if this combination can help control the cancer with fewer side effects.
SanmingAges 60 years+ - NCT07369830Recruiting
Probiotics for bowel function after rectal cancer surgery
This trial tests whether taking a probiotic supplement (Clostridium butyricum) can improve gut health and bowel function after surgery for very low rectal cancer. It may help patients who have a temporary ileostomy and are planning to have it reversed within 6 months.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07431892Recruiting
Pain after robotic vs. laparoscopic colon cancer surgery
This study compares pain levels after two types of minimally invasive colon cancer surgery: robotic and laparoscopic. It aims to see if one approach leads to less pain, which may help you recover more comfortably.
MadridAges 18 years+ - NCT07501845Recruiting
Registry for MAASTRO rectal applicator treatment
This study collects data from people treated with a special rectal applicator for rectal cancer. The goal is to observe long-term outcomes and improve future treatments.
MaastrichtAges 18 years+ - NCT07537998RecruitingPhase 2/Phase 3
Intestinal Fluid Recycling to Reduce Bowel Problems After Rectal Cancer Surgery
This trial tests a surgical technique that recycles intestinal fluids during rectal cancer surgery to help prevent bowel dysfunction and frequent bowel movements after surgery. If you've had mid-to-low rectal cancer removed and created a temporary opening (stoma), this study may help improve your quality of life.
Guangzhou, GuangdongAges 18–75 - NCT07573371Recruiting
Understanding bowel changes after rectal cancer surgery
This study helps doctors better understand and treat bowel control problems that can happen after rectal cancer surgery or other rectal treatments. If you've had this surgery or treatment, the study team wants to learn more about your recovery and test new ways to help.
AalborgAges 18 years+ - NCT07646639RecruitingPhase 2
Radiation, chemotherapy, and immunotherapy for advanced rectal cancer
This study tests a combination of radiation therapy, chemotherapy drugs (capecitabine and oxaliplatin), and two types of immunotherapy (a PD-1 blocker and IL-2) for locally advanced rectal cancer. The goal is to see if this combination helps shrink tumors and improve outcomes before surgery.
Nanjing, JiangsuAges 18–70 - NCT05877456Enrolling by invitation
Checking a polyp-removal scoring tool for doctors
This study tests and confirms a scoring tool (GPAT) that helps describe how well doctors perform polyp removal during endoscopy. It may help standardize training and assessment, which can improve consistency in care.
Ghent, GentAges 18–100 - NCT06330805RecruitingPhase 2
Comparing heart effects of two hormone therapies for prostate cancer
This trial compares two hormone therapies, relugolix and leuprolide, to see which one is better for your heart health in men with prostate cancer. It's for men with a specific type of prostate cancer that is not yet advanced.
Columbus, OhioAges 18 years+ - NCT07757490Recruiting
Sonablate HIFU registry for prostate cancer and BPH
This study is a registry that collects information from men who have had Sonablate HIFU treatment for prostate cancer or enlarged prostate (BPH). It will help doctors learn more about how well this treatment works in real life.
Indianapolis, IndianaAges 18 years+ - NCT06266832RecruitingPhase 2
Short-course radiation with immunotherapy and chemo for rectal cancer
This trial tests a combination of short-course radiation, an immunotherapy drug (adebrelimab), and chemotherapy (CAPEOX) before surgery to help preserve the rectum in people with MSS/pMMR ultra-low rectal cancer. The goal is to shrink the tumor enough to avoid removing the rectum.
Hangzhou, ZhejiangAges 18 years+ - NCT06804785Recruiting
AI-assisted MRI reading for prostate cancer diagnosis
This trial is testing a new 'smart' system that combines artificial intelligence (AI) with doctor oversight to better read prostate MRI scans and guide decisions for men who have not yet had a biopsy. It may help avoid unnecessary biopsies while catching cancer early.
Bethesda, MarylandAges 18–89 - NCT06931808Enrolling by invitationPhase 4
Fecal transplant with chemo, radiation, and immunotherapy for advanced colon cancer
This study tests a combination of fecal microbiota transplant, chemotherapy, radiation, and immunotherapy (sintilimab) for people with locally advanced rectal cancer. The goal is to see if this approach improves treatment outcomes.
Ningbo, ZhejiangAges 18–75 - NCT05482516RecruitingPhase 3
Testing blood test–guided treatment for GI cancers in remission
This Phase 3 study tests whether giving treatment based on a positive blood test for “minimal cancer signals” (ctDNA) can help people with certain GI cancers stay cancer-free longer. It focuses on people who have finished curative-intent therapy and currently have no visible disease on scans, but their blood test is still positive.
Washington D.C., District of ColumbiaAges 18 years+ - NCT05652361Recruiting
AI guidance system for robotic rectal cancer surgery
This trial tests a machine-learning (AI) system that may help guide surgeons during robotic rectal cancer operations. It’s meant to support safer, more accurate surgery while comparing outcomes to standard surgical guidance.
Dresden, SaxonyAges 18 years+ - NCT07456852RecruitingPhase 1/Phase 2
Can vasodilators help with chemo side effects in GI cancer?
This trial tests two drugs (isosorbide mononitrate and diltiazem) to see if they can prevent blood vessel damage caused by chemotherapy drugs like 5-FU or capecitabine in people with gastrointestinal cancers.
Rochester, MinnesotaAges 18 years+ - NCT04725903Recruiting
Proton beam radiation for high-risk prostate cancer
This trial tests proton radiation therapy for people with high-risk prostate cancer. It may help by delivering radiation in a more targeted way, with the goal of controlling the cancer while reducing exposure to nearby healthy tissue.
Atlanta, GeorgiaAges 18 years+ - NCT06325982Recruiting
Preventing rectal injury from radiation with a medicated enema
This trial tests whether a medicated enema can help prevent radiation damage to the rectum during pelvic radiotherapy. It may be a good option if you are starting radiation to the pelvis or rectum and are otherwise in good health.
Xiamen, FujianAges Any age - NCT05663775RecruitingPhase 2
Mesalamine to prevent bowel inflammation after melanoma immunotherapy
This study tests whether taking mesalamine can prevent colitis (bowel inflammation) in people with advanced melanoma who are treated with ipilimumab plus nivolumab. It may help reduce dangerous stomach or bowel side effects from this cancer treatment.
Edmonton, AlbertaAges 18 years+
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Common questions
- Are there clinical trials for rectal cancer patients?
- Yes. Clin2 currently lists 365 recruiting rectal cancer patients studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a rectal cancer patients trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a rectal cancer patients trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.