Clinical trials
Recurrence clinical trials
Below are recruiting recurrence clinical trials, each written for real people, not researchers. We’re tracking 1,422 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07194980RecruitingPhase 2
Study of a pill and CAR T-cell therapy for CLL/SLL
This study tests a combination of two treatments: a targeted pill (nemtabrutinib) and a special immune cell therapy (lisocabtagene maraleucel, or liso-cel) for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has come back or has not responded to previous treatment. The goal is to see if giving the pill first helps the cell therapy work better.
Seattle, WashingtonAges 18 years+ - NCT06681246Recruiting
How gut bacteria affect weight regain after weight loss
This study looks at how the natural bacteria in your gut (the microbiome) might be linked to regaining weight after losing it. It tests whether a short course of antibiotics or a placebo (a sugar pill) affects this process. The goal is to find new ways to help people keep weight off long-term.
RehovotAges 18–65 - NCT07062354Enrolling by invitationPhase 2
Study of amivantamab plus chemo for head and neck cancer
This trial tests a new drug (amivantamab) combined with two chemotherapy drugs (carboplatin and paclitaxel) for people with head and neck cancer that has spread or come back after treatment and cannot be removed by surgery. This study aims to see if this combination can help shrink tumors.
Tucson, ArizonaAges 18 years+ - NCT05057702Recruiting
Personalized surgery-focused treatment plan for relapsed brain cancer
This study tests a personalized treatment plan for children and young adults whose medulloblastoma or ependymoma has come back. It aims to guide doctors using new tissue from surgery or biopsy after earlier treatments are fully finished.
Los Angeles, CaliforniaAges 1–39 - NCT07100730RecruitingPhase 3
A new drug for recurrent glioblastoma vs standard care
This trial tests a new targeted drug, TLX101-Tx, added to standard care for people with glioblastoma that has come back after initial treatment. It aims to see if the combination helps control the tumor better than standard care alone.
Gold Coast, QueenslandAges 18 years+ - NCT07288216RecruitingPhase 2
Switching to KPL-387 alone for well-controlled pericarditis
This study tests whether a new drug, KPL-387, can keep your pericarditis under control as your only treatment, after you have been stable on other medicines. It is for people whose pericarditis is well controlled now but who have had flares in the past.
Phoenix, ArizonaAges 18–80 - NCT07755397RecruitingPhase 1
Study of JBI-778 for lung, brain, and salivary gland tumors
This trial tests a new oral medication, JBI-778, in patients with certain types of lung cancer, brain tumors, or salivary gland cancer. The drug is designed to target specific genetic changes in these tumors, and the study aims to assess its safety and effectiveness.
Surat, GujaratAges 18 years+ - NCT06926868RecruitingPhase 2/Phase 3
Study of a new drug versus chemotherapy for advanced triple-negative breast cancer
This trial tests a new investigational drug called izalontamab brengitecan against standard chemotherapy for people with advanced triple-negative breast cancer who cannot receive immunotherapy. The goal is to see if the new drug works better at shrinking or slowing the cancer.
Hot Springs, ArkansasAges 18 years+ - NCT06940297RecruitingPhase 2
Dasatinib and quercetin with Carvykti for advanced multiple myeloma
This trial tests whether adding two drugs (dasatinib and quercetin) before CAR-T therapy (Carvykti) can improve outcomes for people with multiple myeloma that has come back or not responded to at least three prior treatments. It aims to see if this combination is safe and effective.
Rochester, MinnesotaAges 18 years+ - NCT07508124RecruitingPhase 4
Steroid cream to prevent repeat UTIs in uncircumcised baby boys
This study tests if a steroid cream applied to the foreskin can help prevent another urinary tract infection (UTI) in uncircumcised baby boys under 6 months old who have already had one confirmed UTI.
Houston, TexasAges birth–5 months - NCT07753499Recruiting
PET scan for recurrent or metastatic thyroid cancer
This study tests a new type of PET scan to find thyroid cancer that has come back or spread. It compares two tracers to see which one better shows the cancer, which may help doctors choose the right treatment.
Xiamen, FujianAges 18–90 - NCT06860542RecruitingPhase 2
Inhaled steroid to prevent lung inflammation from returning after immunotherapy
This trial tests whether using an inhaled steroid (budesonide) can help prevent lung inflammation (pneumonitis) from coming back in people who have had it caused by immunotherapy cancer treatment. It may be an option for patients who need extra support after their first bout of this side effect.
Calgary, AlbertaAges 18 years+ - NCT07085338RecruitingPhase 2
N-803 with chemoimmunotherapy for relapsed neuroblastoma
This trial tests adding a new drug called N-803 to a standard chemo-immunotherapy combination for children and young adults with high-risk neuroblastoma that has come back or not responded to previous treatments. The goal is to see if this combination works better at fighting the cancer.
San Francisco, CaliforniaAges Up to 30 years - NCT06900595RecruitingPhase 2
Cabozantinib with immunotherapy for advanced adrenal cancer
This trial tests adding the targeted drug cabozantinib to the immunotherapy cemiplimab for people with advanced adrenocortical carcinoma that cannot be removed by surgery or has spread. It checks if the combination works better than cabozantinib alone.
La Jolla, CaliforniaAges 12 years+ - NCT07173829Recruiting
Study of why glioblastoma comes back
This trial collects tumor samples to study what causes glioblastoma to return. It may help scientists find better treatments.
BordeauxAges 18 years+ - NCT02781870Recruiting
3D laparoscopic groin hernia repair with special mesh fix
This study looks at a laparoscopic (keyhole) operation to repair a groin (inguinal) hernia using a 3D “visible” mesh, with or without an added fixation method. If you have a first-time hernia on one side and are planning a laparoscopic repair, this trial may be an option to discuss with your surgical team.
GhentAges 18–80 - NCT07698886RecruitingPhase 2
Laser plus Geniwa gel for recurring genital warts
This trial tests whether adding a special gel (Geniwa gel) to standard laser treatment helps prevent genital warts from coming back. It may be an option for people who have already tried laser treatment but their warts returned.
Hanoi, None (International)Ages 18 years+ - NCT07463807RecruitingPhase 1/Phase 2
Comparing two drug combinations for multiple myeloma that returned quickly
This study tests a new combination of two drugs, teclistamab and pomalidomide, against the usual treatment of three drugs for multiple myeloma that has come back shortly after a standard treatment. The goal is to see if the new combination works better or is safer.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07495124RecruitingPhase 2
IGFBP-2 vaccine to prevent ovarian cancer return
This trial tests a vaccine that targets a protein called IGFBP-2 to prevent ovarian cancer from coming back. It is for people whose CA-125 blood test shows the cancer might be returning, but who don't yet have tumors visible on scans.
Seattle, WashingtonAges 18 years+ - NCT07444619RecruitingPhase 1
Combination drugs for returning soft tissue sarcoma in young people
This trial tests if combining four drugs (pazopanib, trabectedin, ipilimumab, and nivolumab) can help treat soft tissue sarcomas that have come back. It is for children and young adults up to age 30.
Houston, TexasAges 1–30 - NCT06879860Enrolling by invitation
Comparing stitch vs no stitch for groin hernia repair
This study compares two ways to fix a mesh during groin hernia surgery: 3D patch with one stitch versus no stitches at all. It aims to see which method leads to less long-term pain and fewer hernias coming back. If you have a first-time, moderately large groin hernia, you may qualify.
Nanchong, SichuanAges 18–80 - NCT06855355Enrolling by invitation
Can CBM588 help prevent colon polyp return?
This study tests a dietary supplement called CBM588 to see if it helps prevent new colorectal polyps from coming back. You may be eligible if you have had polyps removed before and recently found new ones.
Kaohsiung City, TaiwanAges 18 years+ - NCT06735664RecruitingPhase 1
Zanubrutinib and odronextamab for Richter's transformation
This trial tests a combination of two targeted drugs for people with Richter's transformation, an aggressive lymphoma that can develop from CLL. The goal is to see if this combination can help control the disease.
Duarte, CaliforniaAges 18 years+ - NCT06524583RecruitingPhase 2
Chemotherapy after surgery for high-risk uterine leiomyosarcoma
This trial tests whether chemotherapy after surgery can help prevent uterine leiomyosarcoma from coming back in patients who are at high risk based on a genetic test of their tumor. It is for women with early-stage cancer (stage I) who have had complete surgery.
AngersAges 18–75
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Common questions
- Are there clinical trials for recurrence?
- Yes. Clin2 currently lists 1,422 recruiting recurrence studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a recurrence trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a recurrence trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.