Clinical trials
Recurrent or Metastatic Solid Tumors clinical trials
Below are recruiting recurrent or metastatic solid tumors clinical trials, each written for real people, not researchers. We’re tracking 3,299 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06697106Recruiting
Can an anti-inflammatory drug prevent urethral stricture recurrence?
This trial tests if taking a COX-2 inhibitor (a type of anti-inflammatory) after a procedure to widen a narrowed urethra can lower the chances of the narrowing coming back. It may help men with a short first-time stricture.
New Valley, New Valley GovernorateAges 18 years+ - NCT07618624Enrolling by invitationPhase 2
Drug combination before surgery for recurrent head and neck cancer
This trial tests three drugs (finotonlimab, cetuximab, and docetaxel) given before surgery to remove recurrent head and neck cancer in patients whose cancer stopped responding to previous immunotherapy. The goal is to shrink the tumor and improve surgical outcomes.
Foshan, GuangdongAges 18–75 - NCT07617753RecruitingPhase 1/Phase 2
CAR-NK Cell Therapy for Recurrent Ovarian Cancer
This trial tests a new type of cell therapy using modified natural killer cells (CAR-NK cells) that are trained to attack ovarian cancer cells. It's designed for patients whose cancer has come back or stopped responding to previous treatments.
Shenzhen, GuangdongAges 18–75 - NCT06161610Recruiting
Laser treatment for returning high-grade glioma
This study tests a laser ablation treatment for people whose high-grade glioma (a fast-growing brain tumor) has come back after standard therapy. The goal is to see if this minimally invasive laser procedure can help control the tumor.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05598528Recruiting
Study why some lung cancers don’t respond to EGFR pills
This study looks at why certain EGFR-positive advanced lung cancers resist third-generation EGFR tablet treatment given as the first treatment. Your body samples and scan results help researchers understand the resistance, which may guide better future care.
Changsha, HunanAges 18 years+ - NCT07609030Recruiting
Brain Training During CAR-T Cell Cancer Treatment
This study tests whether special brain exercises can help protect thinking and memory skills during CAR-T cell therapy—a newer cancer treatment for certain blood cancers. Researchers want to see if training your brain during treatment reduces side effects on memory and mental function.
Columbus, OhioAges 18 years+ - NCT07608653Recruiting
Minimally invasive surgery for recurrent groin hernias
This trial tests a keyhole (laparoscopic) surgical technique to repair inguinal hernias that have returned after previous surgery. The goal is to evaluate how well this approach works and what outcomes patients experience.
SohagAges Any age - NCT02572778Recruiting
Study using patient tumor samples in head and neck cancer
This study uses tumor tissue taken from people with head and neck cancer, then grows it in a lab to better understand the cancer and predict responses. If you have a new or returning cancer and can share key medical details and follow-up information, you may be able to take part.
BrusselsAges 18 years+ - NCT05953350RecruitingPhase 1/Phase 2
Hydroxychloroquine plus CDK4/6 medicine for advanced solid tumors
This trial tests whether adding hydroxychloroquine (a medicine that affects a cell recycling process called autophagy) can boost the anti-cancer effect of high-dose CDK4/6 inhibitor treatment in advanced solid tumors. It may help tumors respond better after prior CDK4/6 treatments have stopped working.
Guangzhou, GuangdongAges 18 years+ - NCT06609850Recruiting
Comparing TACE plus lenvatinib with or without ablation for recurrent liver cancer
This trial compares two treatments for people whose liver cancer has come back (recurrent intermediate-stage hepatocellular carcinoma). One group gets TACE plus lenvatinib (a targeted therapy), the other gets TACE plus lenvatinib plus ablation (a procedure that destroys tumors with heat or cold). The goal is to see which combination works better.
Beijing, None SelectedAges 18–75 - NCT07594106RecruitingPhase 1/Phase 2
New immunotherapy for advanced prostate or kidney cancer
This trial tests new experimental drugs (REGN15505 and REGN4336) designed to target and attack cancer cells in advanced prostate cancer or kidney cancer. These drugs work by boosting your immune system to recognize and destroy cancer, and may be combined with other approved immunotherapy drugs.
Goodyear, ArizonaAges 18 years+ - NCT07594015RecruitingPhase 2
Pembrolizumab and lenvatinib for recurrent endometrial cancer
This trial tests a combination of two drugs, pembrolizumab and lenvatinib, for women whose endometrial cancer has returned after initial treatment with immunotherapy. The goal is to see if this combination can help shrink or control the cancer.
Miami, FloridaAges 18 years+ - NCT07579208RecruitingPhase 1
CAR NK cells for recurrent glioblastoma brain tumors
This trial tests engineered immune cells (called NK cells) that are designed to fight glioblastoma, a deadly brain cancer. The cells are injected directly into the tumor and may help patients whose cancer has come back after standard treatment.
Houston, TexasAges 18 years+ - NCT07570979RecruitingPhase 1
Testing INR731 for Metastatic Prostate Cancer
This trial tests a new drug called INR731, given by mouth, for men with prostate cancer that has spread to other parts of the body. The study will check if the drug is safe and how well it works, either alone or combined with other prostate cancer medicines.
Boston, MassachusettsAges 18 years+ - NCT06430983Recruiting
Relearning liver cancer: a study of recurrent cases
This trial studies patients with liver cancer, including both the common type (hepatocellular carcinoma) and other types. It aims to understand the cancer better by collecting blood samples and medical information.
Nanjing, JiangsuAges 18–75 - NCT06719232Recruiting
Testing a new way to give bladder treatment without a catheter
This study tests a catheter-free method for delivering medication directly into the bladder. It may help patients with bladder pain, recurrent infections, bladder cancer, or cystitis after radiation or chemotherapy.
BudapestAges 18–80 - NCT05989178Recruiting
Recurrent Pregnancy Loss Registry
This study is a registry for people who have had repeated pregnancy losses. It will collect information to better understand and help manage this condition.
Vancouver, British ColumbiaAges 15–49 - NCT02824731Recruiting
Proton vs photon radiation for certain brain tumors
This study compares two types of radiation—protons and photons (X-rays)—for specific brain tumors or tumor returns. It aims to see which approach works best and is safest for you, based on how much and where the radiation is delivered.
DresdenAges 18 years+ - NCT06735391RecruitingPhase 3
JMT101 plus osimertinib vs osimertinib for EGFR-mutant lung cancer
This trial tests a new combination of two targeted drugs (JMT101 and osimertinib) against osimertinib alone for people with advanced lung cancer that has an EGFR mutation. The goal is to see if the combination works better as a first treatment.
GuangzhouAges 18 years+ - NCT05615974RecruitingPhase 1/Phase 2
LM-101 injection study for advanced solid tumors
This Phase I/II study tests LM-101, a new injection, in adults with advanced solid cancers that have already been treated and kept growing. It aims to see how safe it is and whether it can shrink tumors or help people live longer.
Guangzhou, GuangdongAges 18 years+ - NCT07551336RecruitingPhase 1
CAR-NK cells for recurrent glioblastoma and high-grade brain tumors
This trial tests a new type of immune cell therapy called CAR-NK cells to treat glioblastoma or high-grade glioma that has come back or gotten worse after standard treatment. The cells are engineered to recognize and attack tumor cells in the brain.
Shenzhen, GuangdongAges 18–75 - NCT07544056RecruitingPhase 2/Phase 3
BEBT-209 Plus Chemotherapy for Triple-Negative Breast Cancer
This study tests a new drug called BEBT-209 combined with chemotherapy (carboplatin and gemcitabine) in women with advanced triple-negative breast cancer that has spread or cannot be surgically removed. The goal is to see if this combination can slow or stop cancer growth better than standard treatments.
Guangzhou, GuangdongAges 18–75 - NCT07543744RecruitingPhase 1
Comparing RPH-030 to Vectibix for metastatic colorectal cancer
This trial tests whether a new drug called RPH-030 works similarly to an existing drug called Vectibix in treating advanced colorectal cancer that has spread. Both drugs will be given alongside chemotherapy (FOLFIRI) as a first-line treatment.
ArkhangelskAges 18 years+ - NCT07541430RecruitingPhase 2
Testing a New Drug for Desmoid Tumors
This study tests a new medication for adults with desmoid tumors (rare, slow-growing tumors that form in connective tissue). You may qualify if your tumor has grown recently, causes pain, or has come back after previous treatment.
Beijing, Beijing MunicipalityAges 18 years+
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Common questions
- Are there clinical trials for recurrent or metastatic solid tumors?
- Yes. Clin2 currently lists 3,299 recruiting recurrent or metastatic solid tumors studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a recurrent or metastatic solid tumors trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a recurrent or metastatic solid tumors trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.