Clinical trials
Replacement clinical trials
Below are recruiting replacement clinical trials, each written for real people, not researchers. We’re tracking 507 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05090540Enrolling by invitation
Less Invasive vs Usual Surgery for Mitral Valve Leaks
This trial compares a less invasive catheter procedure to the standard surgical operation to treat “secondary” leaking of the mitral valve. It may help people with significant valve leak decide which approach works better for reducing symptoms and heart strain.
Saint-DenisAges 18–90 - NCT05125822Recruiting
Study of how bodies change weight in youth with obesity
This study looks at what helps or drives weight changes in children and teens with obesity. You may be asked about growth and body changes to better understand why weight changes happen and how to manage them.
Chicago, IllinoisAges 11–15 - NCT05023369RecruitingPhase 4
Hip replacement patients may get an added steroid injection
This trial tests whether a steroid injection placed around the hip after hip replacement can reduce pain and shorten hospital stay. It is meant for older adults who are having hip replacement due to a broken femoral neck bone.
LuganoAges 50–90 - NCT05045066RecruitingEarly Phase 1
Vitamin D treatment study for Black men with prostate cancer
This early-phase study looks at how vitamin D replacement affects the immune system in Black/African American men with prostate cancer. It’s testing whether bringing vitamin D levels into a healthier range changes immune signals that may matter for cancer health.
Scottsdale, ArizonaAges 18 years+ - NCT04867317RecruitingPhase 3
Growth hormone treatment for veterans with mild traumatic brain injury and hormone deficiency
This study tests whether giving growth hormone, a natural substance that helps the body grow and repair tissues, can improve symptoms in veterans who have both a mild traumatic brain injury (concussion) and a deficiency in growth hormone. If you qualify, you may receive the treatment or a placebo (inactive shot), and the study will track your quality of life and symptoms over time.
Birmingham, AlabamaAges 21–55 - NCT04787679Recruiting
CT-planned testing to improve hip fracture and replacement care
This study uses your routine pre-surgery CT scan to study a broken or replacement hip bone with computer modeling and lab-style analysis. It aims to help doctors better understand bone healing and improve how hip fractures and replacements are handled.
Miano, MilanoAges 18 years+ - NCT04848896Recruiting
Safety and outcomes study of a smart knee replacement
This trial studies whether a “smart” knee replacement system (CORI) is safe and works well for people getting a total knee arthroplasty (TKA). If you’re a good candidate for a cemented standard knee replacement, the study follows you for two years to check results after surgery.
EppingAges 18 years+ - NCT03746964Recruiting
MRI study of the heart’s aorta before planned surgery
This study uses a special MRI scan to measure how the ascending aorta (a large blood vessel) moves and behaves before planned surgery. It may help doctors better understand the mechanics of an aortic aneurysm and improve future surgical planning.
DijonAges 18 years+ - NCT04641039Recruiting
Study of scar differences after lumbar disc replacement
This study compares how postoperative scars look and behave after certain lumbar disc replacement surgery. It may help doctors choose approaches that reduce excessive scar-related problems after surgery.
Valencia, ValenciaAges 18–50 - NCT04532047RecruitingPhase 1
Fetal enzyme therapy trial for certain inherited storage disorders
This Phase 1 trial tests an enzyme replacement treatment given to a developing baby before birth for specific inherited “lysosomal storage” diseases. The goal is to see if the treatment is safe and can improve outcomes for babies diagnosed in pregnancy.
San Francisco, CaliforniaAges 18–50 - NCT04507412RecruitingPhase 4
IV steroid before shoulder surgery to reduce inflammation
This trial studies whether giving dexamethasone through a vein (an anti-inflammatory steroid) around the time of total shoulder replacement surgery improves outcomes. It may help lower inflammation and related discomfort, but you must meet specific health and medication safety criteria to join.
LuganoAges 58–85 - NCT04432012RecruitingPhase 4
Compare steroid shots versus other delivery after knee replacement
This study compares different ways of giving steroid medicine after a total knee replacement to see which approach works best and is well-tolerated. You may qualify if you’re getting a first (not repeat) knee implant and can follow the study steps.
LuganoAges 50–85 - NCT04438525Recruiting
BAT test to replace sting challenge in venom allergy care
This study looks at whether a BAT (a blood test) can stand in for sting/venom “challenges” for people already receiving venom immunotherapy. If it works, it could help patients avoid more risky or uncomfortable challenge procedures while still checking whether treatment is working.
GrazAges 18–70 - NCT04277416Enrolling by invitation
Testing a new hip replacement system and how patients do
This study follows people getting a primary total hip replacement using the Entrada hip system to see how long it lasts and how well it works. You may be offered this specific hip implant and would be followed through study visits to measure recovery and outcomes.
Portland, OregonAges 18–80 - NCT04355572Recruiting
Vitamin D replacement study for teens at risk of PCOS
This study looks at how taking vitamin D affects hormone levels and emotional well-being in teen girls who may develop PCOS. If you have low vitamin D and meet PCOS risk criteria, the study may test whether vitamin D helps you feel and function better.
New Haven, ConnecticutAges 13–21 - NCT04258488RecruitingPhase 4
Blood thinner pill vs warfarin after mechanical aortic valve
This study compares a blood thinner pill (a factor Xa inhibitor) with warfarin (vitamin K antagonist) in people who have had a mechanical aortic valve replacement. It looks at which option works better and is safer over the long term.
Bucheon-siAges 19 years+ - NCT04073420Recruiting
Cardiac surgery registry to track Medtronic device outcomes
This registry collects real-world information from people who have had—or plan to have—an eligible Medtronic cardiac surgery device. It aims to better understand how these treatments do over time and help guide future care.
Marietta, GeorgiaAges Any age - NCT04139616Recruiting
Testing a planned heart rhythm plan after aortic valve replacement
This study tests an algorithm—a step-by-step plan—for how doctors manage abnormal heart rhythms after transcatheter aortic valve replacement (TAVR). It may help guide safer, more consistent care in the weeks after the procedure.
Québec, QuebecAges 18 years+ - NCT04049331RecruitingPhase 2
Testosterone therapy for cancer survivors with fatigue
This trial tests whether testosterone replacement can help male cancer survivors who have ongoing fatigue and low testosterone levels. It is for men who have completed chemotherapy or radiation and are cancer-free for at least a year.
Boston, MassachusettsAges 18–54 - NCT03965143Recruiting
Talus replacement registry for adults who need new ankle bone
This study is a real-world registry that follows adults who need a talus (ankle bone) replacement and are able to participate over time. It helps doctors understand outcomes and safety, especially the risk of infection, and may offer structured follow-up care.
Columbia, MissouriAges 18 years+ - NCT03991728Recruiting
TMJ implant registry for adults with a new jaw joint replacement
This registry is for adults getting an artificial (alloplastic) full replacement of the jaw joint (TMJ). It collects real-world information about your implant and care to help improve future outcomes.
São PauloAges 18 years+ - NCT03747146Recruiting
Enhanced recovery plan for knee replacement pain control
This study tests an “enhanced recovery” approach for people getting total knee replacement, focused on better pain control using regional anesthesia and a home pain medicine plan. It may help you recover more comfortably and follow the care plan more smoothly after surgery.
New York, New YorkAges 18–65 - NCT03610789Enrolling by invitation
Follow-up study for a specific hip implant system
This study monitors people who already received a specific hip replacement device (REDAPT) to check how it’s doing over time. It may help confirm long-term safety and performance of these implant parts.
Rancho Mirage, CaliforniaAges 18 years+ - NCT03713853Recruiting
Compare hip surgery methods for new pelvic bone fractures
This study compares two ways of fixing a recently broken acetabulum (the hip socket): one method keeps/repairs the socket (ORIF) and the other replaces it (THA). It aims to find which surgery approach leads to better outcomes for people who can have surgery soon after the injury.
Toronto, OntarioAges 60 years+
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Common questions
- Are there clinical trials for replacement?
- Yes. Clin2 currently lists 507 recruiting replacement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a replacement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a replacement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.