Clinical trials
Safety and Effectiveness clinical trials
Below are recruiting safety and effectiveness clinical trials, each written for real people, not researchers. We’re tracking 398 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06830694RecruitingPhase 2
Trial of a new drug combo for a rare type of lung cancer
This trial tests a new drug (tarlatamab) combined with chemotherapy and immunotherapy for people whose lung cancer has changed from one type (adenocarcinoma) to small cell lung cancer after treatment with EGFR targeted therapy. The goal is to see if this combination is safe and works well.
Seoul, Gangnam-guAges 19 years+ - NCT06838286Recruiting
Study of triple therapy for type 2 diabetes
This study looks at the safety and effectiveness of adding a third oral diabetes medicine to your current two-drug combination. It is for adults with type 2 diabetes whose blood sugar is not well controlled on metformin plus one other pill.
Seongnam-si, Gyeonggi-doAges 19 years+ - NCT06838845Recruiting
A study on upadacitinib for Chinese adults with moderate to severe ulcerative colitis
This study is looking at how well the drug upadacitinib works and how safe it is for Chinese adults with moderate to severe ulcerative colitis. It is not a treatment trial, but will observe patients who are already taking upadacitinib as decided by their doctor.
Guangzhou, GuangdongAges 18 years+ - NCT06843590RecruitingPhase 2
Study of ALKS 2680 for Idiopathic Hypersomnia
This trial tests a new medicine called ALKS 2680 for people with Idiopathic Hypersomnia (a condition that causes extreme sleepiness without a clear cause). The goal is to see if it is safe and effective at helping you stay awake during the day.
Cullman, AlabamaAges 18–70 - NCT06867315Recruiting
Treating enlarged prostate with a new electrical pulse device
This study tests a new device called the Steep Pulse Therapy System that uses short electrical pulses to destroy extra prostate tissue without cutting. It is for men with moderate to severe BPH symptoms who have not had prior prostate surgery.
Hangzhou, ZhejiangAges 50 years+ - NCT06876207Recruiting
Real-world study of Control-IQ in teens with type 1 diabetes who exercise regularly
This study observes how well the Control-IQ insulin pump system works for teenagers with type 1 diabetes who exercise at least twice a week. It aims to see if the technology is safe and effective during regular physical activity.
Messina, ItalyAges Up to 20 years - NCT06890273Recruiting
Study of durvalumab and olaparib for endometrial cancer
This study looks at how well two drugs, durvalumab and olaparib, work together after initial chemotherapy for advanced or recurrent endometrial cancer. It may help patients who have not had many treatment options before.
AmbergAges 18–130 - NCT06895590Recruiting
Testing a new water-based blood pressure cuff
This trial tests a new, very accurate blood pressure cuff that uses water to get a better reading. It is for adults who already need a standard blood pressure cuff and an arterial line as part of their hospital care.
Boston, MassachusettsAges 18 years+ - NCT06896279Recruiting
Temporal interference brain stimulation for consciousness disorders
This trial tests a new type of brain stimulation called temporal interference (TI) to see if it can help people with severe disorders of consciousness. If you or your loved one has been in a minimally conscious or vegetative state for at least a month and is medically stable, this study may be an option.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06904755RecruitingPhase 1
Stem cell therapy for liver failure through blood purification
This trial tests whether adding mesenchymal stem cells to a blood-cleaning procedure helps people with acute liver failure recover. It may reduce inflammation and improve liver function.
Guangzhou, GuangdongAges 18–65 - NCT06907056RecruitingPhase 4
A study on a simpler HIV medication combination
This study tests if a two-drug HIV regimen (darunavir/cobicistat plus lamivudine) works as well as a standard three-drug regimen in men whose HIV is already well-controlled. If effective, this could mean taking fewer medications.
Mexico City, Mexico CityAges 18–70 - NCT06911359RecruitingPhase 2
Anti-inflammatory vs. Prolotherapy for Knee Osteoarthritis
This study tests whether anti-inflammatory medications or dextrose prolotherapy (sugar water injections) can reduce knee pain and improve function in people with knee osteoarthritis. If you are a military healthcare beneficiary with moderate to severe knee pain, you may be able to join.
Travis AFB, CaliforniaAges 45–75 - NCT06917482RecruitingPhase 1
Testing a new drug called BW-40202 in healthy people
This study tests a new medicine called BW-40202 for the first time in people. It is for healthy volunteers to see if the drug is safe and how it works in the body. You must be in good general health to take part.
Brisbane, QueenslandAges 18–60 - NCT06923111Recruiting
Xromi safety study for children under 2 with sickle cell disease
This study is checking how safe and effective Xromi is for babies and toddlers (under 2 years old) with sickle cell disease. It compares kids who take Xromi to those who don't, to see if it helps prevent problems.
HamburgAges 9 months–1.9 years - NCT06968741Recruiting
Study of a new artificial urinary sphincter for men with stress incontinence
This study tests a new device called UrOActive that helps men with stress urinary incontinence (leaking urine when coughing, sneezing, or moving). It aims to see if the device is safe and works well to control leaks.
Los Angeles, CaliforniaAges 22 years+ - NCT06973031Recruiting
Testing a new system for treating atrial fibrillation
This trial tests a new device that uses pulsed electric fields to treat atrial fibrillation (AF), a type of irregular heartbeat. It aims to see if this approach is safe and effective for people with AF that comes and goes or lasts for a short time.
KaiserslauternAges 18–80 - NCT07001280Recruiting
Garadacimab for hereditary angioedema (HAE)
This study looks at how well a drug called garadacimab works and how safe it is for people with hereditary angioedema (HAE), a condition that causes sudden swelling. It tests the drug in people who are starting it for the first time as part of their regular care.
Phoenix, ArizonaAges 12 years+ - NCT07009847Recruiting
Study of the R21/Matrix-M malaria vaccine
This study looks at how well the R21/Matrix-M malaria vaccine works and how safe it is in children who received it. It compares children who got malaria (or died) to healthy children who also got the vaccine.
Bousse, Burkina FasoAges 5 months+ - NCT07037537Recruiting
Nipple-sparing mastectomy with immediate reconstruction (fat and implant)
This trial tests a breast cancer surgery that removes the breast but saves the nipple, followed by immediate reconstruction with an implant and some of your own fat. It's for women with early-stage cancer that hasn't spread to lymph nodes.
Zhengzhou, HenanAges 18–70 - NCT07052396Recruiting
Dupilumab for COPD: long-term real-world study
This study looks at how well dupilumab works over time for people with COPD who still have symptoms despite standard treatments and who have a certain type of inflammation (elevated eosinophils). It uses data from regular doctor visits and patient questionnaires to understand real-world benefits and safety.
AuerbachAges 18 years+ - NCT07062094Recruiting
Safety and Effectiveness of the Orbera365 Balloon for Weight Loss
This study tests a temporary balloon placed in your stomach to help with weight loss. The balloon stays in place for about a year and is removed at the end of the study. It is for people with a BMI between 30 and 50 who are looking for a non-surgical option.
PragueAges 18 years+ - NCT07083206Recruiting
Pitavastatin/ezetimibe for high cholesterol
This trial tests a combination pill of two cholesterol-lowering medicines (pitavastatin and ezetimibe) in adults who have been taking either atorvastatin or rosuvastatin for at least 3 months. It aims to see if switching to this new combination is safe and effective.
Yongin-siAges 19 years+ - NCT07104955Recruiting
Study on software to improve team meetings
This trial tests a new software tool designed to help medical teams work together more effectively and safely during multi-disciplinary meetings. If you are part of a medical team that holds these meetings, your participation could help improve how decisions are made.
LondonAges Any age - NCT07105579RecruitingPhase 2
Blinatumomab and donor cells after transplant for high-risk B-ALL
This trial tests whether giving two drugs—blinatumomab (an immunotherapy) and donor lymphocyte infusions (white blood cells from your donor)—can help prevent leukemia from coming back after a stem cell transplant for high-risk B-ALL. It is for people who are in remission with no sign of leukemia cells.
HangzhouAges 14–65
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Common questions
- Are there clinical trials for safety and effectiveness?
- Yes. Clin2 currently lists 398 recruiting safety and effectiveness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a safety and effectiveness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a safety and effectiveness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.