Clinical trials
Safety and Effectiveness clinical trials
Below are recruiting safety and effectiveness clinical trials, each written for real people, not researchers. We’re tracking 386 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06526195Recruiting
A study of CardioMEMS and HeartMate 3 for advanced heart failure
This trial tests if a combination of a tiny lung-artery pressure sensor (CardioMEMS) and a mechanical heart pump (HeartMate 3) is safe and effective for people with advanced heart failure. If you qualify, you'll either get the heart pump plus standard medical therapy, or continue with standard therapy alone and have your pressure monitored remotely.
Phoenix, ArizonaAges 18 years+ - NCT06501872Recruiting
Custom stent-graft for large chest and belly aneurysms
This study tests a special stent-graft, custom-shaped by your doctor to fit your aneurysm while keeping blood flow to important organs like your kidneys and stomach. It's for people with large aneurysms in the chest and belly who cannot safely have open surgery.
Lebanon, New HampshireAges 50–95 - NCT06511167Recruiting
Study of TIGR® Matrix in breast reconstruction after mastectomy
This study looks at how a special mesh called TIGR® Matrix affects quality of life, safety, and effectiveness after breast reconstruction surgery. It is for women who need or choose to have their breasts removed and reconstructed.
Weinheim, Baden-WurttembergAges 18 years+ - NCT06487078Recruiting
Study of Lorlatinib for untreated ALK-positive lung cancer
This study looks at how well and how safely the drug lorlatinib works in people with a certain type of advanced lung cancer (ALK-positive NSCLC) who have not had treatment for their advanced cancer yet. The goal is to see how effective it is in the real world.
Paris, ParisAges 18 years+ - NCT06487312Enrolling by invitation
Testing a remote automated ultrasound system for exams
This trial tests a remote, automated ultrasound system that may allow you to get an ultrasound exam without the doctor being in the same room. The goal is to see if it works as well as a standard ultrasound and is safe to use.
Wuhan, HubeiAges 18 years+ - NCT06467110Enrolling by invitation
Study of SQ-Kyrin TMVr System for leaky mitral valve
This trial tests a new device called the SQ-Kyrin TMVr System to treat severe mitral regurgitation (a leaky heart valve) in people who are not good candidates for traditional open-heart surgery. The goal is to repair the valve without major surgery, using a catheter-based approach.
Shenyang, LiaoningAges 18 years+ - NCT05413057Recruiting
Testing blood pressure pills with two or three medicines
This trial studies whether fixed-dose blood pressure medicines—either two drugs (fimasartan + amlodipine) or three drugs (fimasartan + amlodipine + hydrochlorothiazide)—work well and are safe. It may help your care team compare how these combinations control blood pressure and what side effects occur.
SeoulAges 19 years+ - NCT06408259RecruitingPhase 3
Comparing ozanimod and fingolimod for children with MS
This study compares two oral medications, ozanimod and fingolimod, to see which one works better and is safer for children and teenagers with relapsing-remitting MS. Both drugs help reduce MS attacks and slow down the disease.
Loma Linda, CaliforniaAges 10–17 - NCT06401772Recruiting
Body posture to prevent repeat brain bleed after surgery
This trial tests whether lying in a specific body position after surgery can help prevent a chronic subdural hematoma from coming back. It is for people aged 60 and older who have had a small drainage procedure for this type of brain bleed.
Shanghai, Shanghai MunicipalityAges 60 years+ - NCT06388720RecruitingPhase 2
Two chemotherapy drugs for bladder cancer after BCG
This study tests a combination of two chemotherapy drugs, mitomycin-C and gemcitabine, given directly into the bladder for people with high-risk bladder cancer that hasn't been controlled with BCG therapy. It's an option for those who can't or don't want to have their bladder removed.
Goyang-siAges 20 years+ - NCT06379789RecruitingPhase 1/Phase 2
Gene therapy for severe hemophilia B
This trial tests a new gene therapy (REGV131-LNP1265) that aims to let your body produce its own factor IX, reducing or stopping the need for regular infusions. It is for children and adults with severe hemophilia B who are already using factor IX replacement therapy.
Phoenix, ArizonaAges 2 years+ - NCT06370182Recruiting
New catheter for clot removal in disabling stroke
This trial tests a new catheter device (ANA Funnel) for removing large blood clots from the brain in people having a disabling stroke. The goal is to see if it safely removes clots better than standard treatment.
Jacksonville, FloridaAges 22–85 - NCT06377969Recruiting
Spinal cord stimulation for chronic pelvic pain
This study tests a device called a spinal cord stimulator — a small implant that sends mild electrical pulses to nerves in your spine — to see if it can reduce long-term pelvic pain that hasn't gotten better with other treatments.
Redwood City, CaliforniaAges 18 years+ - NCT06328608RecruitingPhase 2/Phase 3
PRX-102 for children with Fabry disease
This study tests a new enzyme replacement therapy called PRX-102 for children with Fabry disease. It aims to see if the drug is safe and helps manage symptoms like pain and eye or skin changes.
Phoenix, ArizonaAges 2–17 - NCT06335082Enrolling by invitation
Study of Farapulse ablation for atrial fibrillation
This registry is collecting information to see how well the Farapulse PFA system works and how safe it is for treating atrial fibrillation (AF), a common heart rhythm problem. If you are scheduled to have an ablation for AF with this system, this study will follow your progress.
Birmingham, AlabamaAges 18 years+ - NCT06324201Recruiting
Long-term safety of a new ablation system for paroxysmal AF
This study tests a new system (QDOT MICRO and VISITAG SURPOINT) used during a catheter ablation procedure to treat atrial fibrillation (AF). It aims to see how safe and effective it is over the long term for people whose AF comes and goes and hasn't been controlled by medication.
Birmingham, AlabamaAges 18 years+ - NCT06312722Recruiting
Optilume BPH catheter system for enlarged prostate symptoms
This trial tests a device called Optilume BPH Catheter System for men with enlarged prostate that causes bothersome urinary symptoms. It aims to see how safe and effective it is in real-world use, offering a possible treatment for blocked urine flow without surgery.
Little Rock, ArkansasAges 50 years+ - NCT06262295Recruiting
Monitoring the safety of AVEIR leadless pacemakers
This study tracks the safety and performance of AVEIR VR LP and AVEIR AR LP leadless pacemakers in people who already have them or will get one. It helps doctors and researchers see how well these small heart devices work over time.
La TroncheAges 18 years+ - NCT06238765Recruiting
Adolescent Eczema Drug Safety Registry
This registry tracks the safety and effectiveness of medications used for moderate to severe atopic dermatitis (eczema) in adolescents aged 10 to 15. It helps doctors understand how well these treatments work and what side effects might occur over time.
Waltham, MassachusettsAges 10–15 - NCT06246136Recruiting
Laser treatment for glaucoma during cataract surgery
This study tests a new laser treatment (ELIOS) for people with open-angle glaucoma who also need cataract surgery. It aims to see if the laser is safe and effective at lowering eye pressure while removing the cataract.
LeuvenAges 40 years+ - NCT06168305Enrolling by invitation
Safety and effectiveness of a GENOSS stent in multiple blocked arteries
This trial tests a new drug-coated stent (GENOSS® DES) for people with blockages in multiple heart arteries. It aims to see how safe and effective the stent is for these patients.
Seoul, SeoulAges 19 years+ - NCT06128447RecruitingPhase 3
New chewable drug for hookworm, roundworm and whipworm
This trial tests a new chewable tablet (ZP5-9676) to treat common intestinal worm infections. It compares the new drug to a placebo (fake pill) to see if it's safe and effective.
AmericaninhaAges 6 months–59 years - NCT04471909Recruiting
Stent graft for aortic arch problems in high-risk patients
This study tests a new stent graft device to treat problems in the aortic arch, such as aneurysms or chronic dissections, without open surgery. It may help people who are not good candidates for traditional open repair.
Birmingham, AlabamaAges 18 years+ - NCT04094090RecruitingPhase 2
Corneal strengthening treatment for thinning eye shape
This Phase 2 study tests how safe and well a corneal cross-linking device (called PXL-Platinum 330) works for people with corneal ectasia (a thinning/steepening of the cornea). If you qualify, the goal is to help stop or slow further worsening of your cornea shape and improve eye stability.
San Francisco, CaliforniaAges 10 years+
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Common questions
- Are there clinical trials for safety and effectiveness?
- Yes. Clin2 currently lists 386 recruiting safety and effectiveness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a safety and effectiveness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a safety and effectiveness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.