Clinical trials
Sepsis clinical trials
Below are recruiting sepsis clinical trials, each written for real people, not researchers. We’re tracking 268 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04513288Recruiting
Immunonutrition with L-citrulline for ICU sepsis patients
This trial tests whether adding L-citrulline to tube feeding (enteral nutrition) can improve outcomes for people in the ICU with sepsis or septic shock. It may help support the body’s immune response while you’re critically ill.
Rennes, Brittany RegionAges 18 years+ - NCT04774705Recruiting
Noninvasive vagus nerve stimulation for sepsis in the ICU
This study tests whether a noninvasive device that stimulates the vagus nerve can help adults with sepsis in the intensive care unit. Researchers want to see if adding this treatment improves outcomes compared with standard ICU care.
GarchesAges 18 years+ - NCT04910464RecruitingPhase 3
Tranexamic acid trial for adults with sepsis in ICU
This trial studies whether early tranexamic acid (a medicine that can reduce bleeding) can change the body’s inflammatory response in people with sepsis. If it works, it may help improve outcomes for certain ICU patients—but you must meet specific safety and eligibility checks.
AsyutAges 18–65 - NCT04955210Recruiting
Study of data sharing in children with severe infections
This trial builds a shared medical data system to better understand severe pneumonia and sepsis in children. Your participation helps clinicians and researchers learn from many cases to improve future care.
Shanghai, Shanghai MunicipalityAges 4 weeks–18 years - NCT05179499RecruitingPhase 3
Early norepinephrine for low blood pressure in sepsis
This Phase 3 trial tests whether starting a medicine called norepinephrine early can improve outcomes for adults with sepsis (a serious body-wide response to infection) and low blood pressure. You might be considered if you’re very early in hospital care and meet specific blood pressure and lactate tests.
AintreeAges 18 years+ - NCT05347238Recruiting
Dopamine or norepinephrine for low blood pressure in very preterm babies
This trial compares two common medicines—dopamine versus norepinephrine—to treat low blood pressure in very preterm babies who have suspected or confirmed late-onset bloodstream infection (sepsis). It may help doctors find which medicine works better and more safely for this specific situation.
Phoenix, ArizonaAges 5 months–7 months - NCT05383963Recruiting
Using ICU routine data to diagnose sepsis sooner
This study checks whether information collected routinely in the ICU can help doctors recognize sepsis or septic shock earlier. If it works, it may improve how quickly diagnosis happens and potentially outcomes for patients.
BerlinAges 18 years+ - NCT05453695RecruitingPhase 1
IV DNase for ICU sepsis with organ stress
This Phase 1 study tests whether an IV medicine called DNase I can safely help people with sepsis who are having worsening organ function. It’s designed to see if the treatment is tolerated and could improve outcomes for ICU patients with early sepsis.
Hamilton, OntarioAges 18–100 - NCT05616130Recruiting
Study of abnormal blood immune activation after trauma or elective hip surgery
This study looks at how the body’s blood-related immune system “switches on” in unusual ways after a major injury or elective hip repair. The researchers hope this helps them understand who is at risk for complications and why, by measuring changes in your blood around the time of surgery or hospital treatment.
Gainesville, FloridaAges 18–100 - NCT05634057Recruiting
Treating sepsis with a medication plus blood thinner
This trial studies whether combining anisodamine (a medicine for certain gut/smooth-muscle effects) with a low-molecular-weight blood thinner helps treat sepsis. It may be aimed at improving outcomes compared with standard care, but eligibility depends on safety factors like bleeding risk and organ function.
Beijing, ChinaAges 18–110 - NCT05681442RecruitingPhase 4
Antibiotics given in different ways for hospital sepsis
This study tests whether giving certain antibiotics intermittently versus continuously, along with a second antibiotic, works better for hospital-acquired sepsis. It may help doctors choose the most effective way to control serious infections.
AmiensAges 18 years+ - NCT05784740Recruiting
Exercise program to improve recovery after sepsis
This study tests whether a structured, supervised exercise program helps people recover better after sepsis. It may improve physical fitness and day-to-day outcomes over about 12 weeks.
Vancouver, British ColumbiaAges 19 years+ - NCT05806762Recruiting
Wearable patch study to predict sepsis rehospitalization
This study uses a wearable skin patch placed on you during a sepsis hospital stay to help predict whether you might need to be readmitted after discharge. It may help doctors identify who is at higher risk of rehospitalization and plan follow-up care earlier.
San Diego, CaliforniaAges 18 years+ - NCT05836272RecruitingPhase 4
Early norepinephrine for low blood pressure in sepsis
This trial tests whether starting norepinephrine early can improve outcomes for adults with sepsis who have low blood pressure. It may help stabilize circulation sooner and reduce complications from severe infection.
TunisAges 18 years+ - NCT05882708RecruitingPhase 4
Ivabradine to slow heart rate in sepsis ICU patients
This study tests whether ivabradine (a heart-rate medicine) can improve blood flow and other vital measurements in adults with sepsis in the ICU. It may help by lowering a fast heart rate when blood pressure is already being supported.
Guangzhou, GuangdongAges 18 years+ - NCT05912413Recruiting
Predicting how people recover from sepsis in the ICU
This pilot study looks at whether doctors can sort ICU patients with sepsis into recovery “types” and predict how well they will recover. It may help future care plans for people after sepsis by identifying who needs what kinds of support.
Birmingham, AlabamaAges 18–80 - NCT05985525Recruiting
Monitoring blood flow in ICU patients with severe infection or shock
This study monitors tiny blood vessels under the tongue using a non-invasive device to see how well blood flows in ICU patients on a breathing machine. Researchers hope to improve care for patients with serious infections or shock.
Winnipeg, ManitobaAges 18 years+ - NCT06045780Recruiting
Sepsis and cell stress: a study of HO-1/CREB3
This trial is studying how a specific protein (HO-1/CREB3) affects stress inside cells (called Golgi stress) in patients with sepsis. It may help doctors understand sepsis better and find new ways to treat it.
Tianjin, Tianjin MunicipalityAges 18–100 - NCT06184659RecruitingPhase 4
Comparing two antibiotics for sepsis in critical illness
This trial compares two common antibiotics, meropenem and piperacillin/tazobactam, to see which works better for adults with sepsis who are critically ill. It aims to help doctors choose the best treatment for serious infections.
Copenhagen, København ØAges 18 years+ - NCT06219135Recruiting
Testing a new method to find infection germs and best antibiotics
This trial is testing a new method (IDBIORIV) to quickly identify the germs causing sepsis and find the right antibiotic. It aims to help patients with a confirmed bloodstream infection get the most effective treatment faster.
BronAges 1 day+ - NCT06287684Recruiting
Sepsis treatment study based on genetic subtypes
This study looks at how different genetic types of sepsis affect treatment. It aims to find better therapies for your specific sepsis subtype.
MsidaAges 18 years+ - NCT06294600RecruitingPhase 3
Clarithromycin to prevent sepsis in pneumonia
This study tests whether the antibiotic clarithromycin can prevent pneumonia from getting worse and turning into sepsis. It is for adults with community-acquired pneumonia who have certain signs of infection in their blood.
Athens, AthensAges 18 years+ - NCT06319248RecruitingPhase 2
Midodrine to treat sepsis and reduce IV vasopressors
This trial tests if the oral medication midodrine can help wean patients with sepsis off IV vasopressors faster, potentially reducing ICU stays and complications.
Scottsdale, ArizonaAges 18 years+ - NCT07599644Recruiting
Sepsis Risk Study in Chinese ICU Patients
This trial studies people with and without sepsis in the ICU to understand why some get very sick from infections. It aims to find better ways to predict who will have complications and guide treatment.
Shaoguan, GuangdongAges 18 years+
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Common questions
- Are there clinical trials for sepsis?
- Yes. Clin2 currently lists 268 recruiting sepsis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sepsis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sepsis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.