Clinical trials
Severe Brain Injury clinical trials
Below are recruiting severe brain injury clinical trials, each written for real people, not researchers. We’re tracking 266 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06370520Recruiting
Teen emotions screening after mild brain injury
This study screens teens aged 11 to 17 for emotional and mental health problems after a mild traumatic brain injury (mTBI, also called concussion or minor head injury). The goal is to find out if the hospital screening helps identify teens who may need extra support.
Sacramento, CaliforniaAges 11–17 - NCT06413173Recruiting
Remote brain stimulation for attention after mild TBI
This trial tests if a remote brain stimulation device can improve attention and concentration in active-duty service members who have had a mild traumatic brain injury. Participants use the device at home while completing tasks to help with daily focus.
San Diego, CaliforniaAges 18–60 - NCT06469983Recruiting
Robotic vs. traditional standing therapy for severe brain injury
This trial compares using a robotic device versus standard therapy to help people with severe brain injury practice standing. It tests whether the robotic approach leads to better recovery of standing ability.
Sant'Angelo dei Lombardi, AvellinoAges 18–75 - NCT06523127Recruiting
Life support decisions and quality of life after severe brain injury
This study looks at patients with severe brain injuries who were in the ICU in 2022. It explores how decisions about life-sustaining treatment affect their quality of life two years later.
Saint-EtienneAges 18 years+ - NCT06560372Recruiting
Bleeding after head injury and brain blood vessel narrowing
This study looks at whether moderate to severe traumatic brain injury with bleeding around the brain can lead to a complication called cerebral vasospasm (narrowing of brain blood vessels). It's being done at Martinique University Hospital to understand how often this happens and how it affects recovery.
Fort-de-FranceAges 18 years+ - NCT06571032Recruiting
EEG guidance for brain stimulation after severe injury
This study tests whether using brain wave monitoring (EEG) can help guide electrical stimulation treatment for people with severe traumatic brain injury. It aims to see if this approach can improve recovery.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06584591Recruiting
Balance training study for people with traumatic brain injury
This study tests a new balance training program called NEUROBALANCE to help improve postural control in people who have had a traumatic brain injury. It uses a non-invasive brain stimulation technique (TMS) to see if it can help improve balance and walking.
West Orange, New JerseyAges 18–75 - NCT06848140Recruiting
Brain stimulation for word-finding problems after TBI
This study tests whether non-invasive brain stimulation can help people with chronic traumatic brain injury (TBI) find words more easily. It involves sessions at Beth Israel Deaconess Medical Center in Boston.
Boston, MassachusettsAges 18–85 - NCT06851156Recruiting
Brain stimulation for disorders of consciousness after severe injury
This trial tests a new type of brain stimulation called transcranial temporal interference stimulation to see if it can help people with severe brain injury who are in a vegetative or minimally conscious state. It uses gentle electrical currents to try to improve awareness and recovery.
Xi'an, ShaanxiAges 18–65 - NCT06871800Recruiting
Blood tests to predict recovery after stroke or brain injury
This study looks at tiny particles in your blood called extracellular vesicles to see if they can help predict how well you will recover after a stroke or brain injury. If you are starting rehabilitation soon after your stroke, you may be able to join.
FlorenceAges 18 years+ - NCT06873477Recruiting
Brain injury study for children and young adults
This study looks at children and young adults who have brain damage from a severe head injury or lack of oxygen at birth. It aims to learn more about these conditions and how to help patients.
Rome, LazioAges Up to 20 years - NCT06966713Recruiting
Predicting recovery after severe brain injury
This study looks at patients with severe traumatic brain injury (TBI) who already need brain pressure or oxygen monitoring. Doctors want to see if certain tests can help predict how well someone might recover.
Chicago, IllinoisAges 18 years+ - NCT07119827Recruiting
Personality traits and recovery after brain injury
This study looks at how your personality might affect recovery after a serious brain injury or stroke. You and a family member will answer a short personality questionnaire to see if certain traits are linked to better recovery.
Verona, VRAges 18–80 - NCT07237386Recruiting
Testing a smart insole for walking in people with brain or spinal cord injury
This study tests a special insole that measures how you walk, compared with a high-tech walking lab. It's for people with stroke, spinal cord injury, or brain injury who can walk on their own for 6 minutes.
GhentAges Any age - NCT06480838Recruiting
Brain blood flow and thinking after traumatic brain injury
This study looks at how the brain controls its own blood flow after a moderate to severe traumatic brain injury (TBI). It uses MRI scans and thinking tests to understand recovery and help improve care for people like you.
Dallas, TexasAges 18–80 - NCT07277309Recruiting
Recovery after brain injury using focused ultrasound
This study tests whether focused ultrasound can help people recover from a brain injury that has left them with a disorder of consciousness. The treatment involves a non-invasive technique that uses sound waves to stimulate brain activity.
Boston, MassachusettsAges 18–79 - NCT07292766Recruiting
Metabolic Profiles After Severe Head Injury
This study looks at chemical changes in the body after a severe head injury. It aims to find markers that may help guide treatment.
Aksaray, AnkaraAges 18–65 - NCT02592291Recruiting
Using a phone app to help manage long-term health needs
This study tests a mobile phone system that helps people with long-term, complex health conditions manage daily life and get support. If you can use a smartphone and pass the study checks, you may be able to try the self-management tools.
Pittsburgh, PennsylvaniaAges 12 years+ - NCT03160131Recruiting
Rehab program to improve vision after brain injury
This study looks at rehabilitation to improve vision after a brain injury. It may help people with significant vision problems regain everyday visual function.
Copenhagen, HellerupAges 14 years+ - NCT03321370Recruiting
Study of brain swelling after severe head injury surgery
This trial looks at changes in brain activity after severe traumatic brain injury (TBI) when patients need emergency skull surgery. The goal is to better understand what happens in the brain after surgery and whether earlier recognition could help care after injury.
Minneapolis, MinnesotaAges 18 years+ - NCT07485361Recruiting
Brain scanning in disorders of consciousness
This trial uses a portable brain scanner (fNIRS) to study brain activity in people with disorders of consciousness, like coma or minimally conscious states. It may help doctors better understand and track recovery in these patients. Healthy volunteers are also needed as a comparison group.
Los Angeles, CaliforniaAges 18 years+ - NCT07560631Recruiting
Facial Tracking to Monitor Brain Injury Recovery
This study uses camera technology to track subtle facial movements as a way to detect awareness and recovery in people with severe brain injuries. It may help doctors better understand and monitor patients who have suffered traumatic brain injury.
Stony Brook, New YorkAges 22–85 - NCT07625995RecruitingPhase 2
Fluid management strategies for traumatic brain injury patients
This study tests two different approaches to managing fluids given to brain injury patients in the ICU—one more restrictive and one more liberal—to see which is safer and more effective. The goal is to find the best balance that protects the brain while supporting overall health.
BrusselsAges 18 years+ - NCT06901310Enrolling by invitation
Hyperbaric oxygen for mild head injuries in combat athletes
This study tests whether hyperbaric oxygen therapy (breathing pure oxygen in a special chamber) helps men recover from mild head injuries better than the current standard care (rest). It is for male unarmed combat athletes who have been suspended for a head injury.
Marshfield, WisconsinAges 18 years+
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Common questions
- Are there clinical trials for severe brain injury?
- Yes. Clin2 currently lists 266 recruiting severe brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.