Clinical trials
Soft Tissue Cancer clinical trials
Below are recruiting soft tissue cancer clinical trials, each written for real people, not researchers. We’re tracking 135 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07470008Recruiting
Registry study for histotripsy in adults with soft tissue tumors
This study is a registry for adults getting histotripsy—a non-invasive ultrasound that breaks down soft tissue tumors—at UCSF. Joining means researchers can follow your treatment and outcomes to learn more about how well histotripsy works.
San Francisco, CaliforniaAges 18 years+ - NCT06674538Enrolling by invitationPhase 1
Antibody trial for advanced solid tumors
This trial tests an antibody treatment for people with stage IV cancer that has not responded to previous treatment. It aims to find a new option for patients with several types of advanced solid tumors.
Hershey, PennsylvaniaAges 18 years+ - NCT04506008RecruitingPhase 2
Radiation followed by surgery for soft tissue sarcoma
This trial tests a treatment plan where you first get a shorter (hypofractionated) course of radiation and then have surgery to remove the tumor. It may help control the cancer locally in certain soft tissue sarcomas and improve surgical outcomes.
Nashville, TennesseeAges 18 years+ - NCT04776525RecruitingPhase 2
Chemotherapy before surgery for certain soft tissue sarcomas
This trial tests a step-by-step (sequential) chemotherapy plan given before surgery for adults with specific types of soft tissue sarcoma. The goal is to shrink or control the tumor before the operation and see how well this approach works and is tolerated.
BergenAges 18 years+ - NCT05468970Recruiting
Study of bone and soft tissue tumors and treatment outcomes
This study looks at people with bone or soft tissue tumors to understand their features, treatments used, and survival outcomes. It may help doctors learn which care approaches work best for different tumor subtypes.
Zhengzhou, HenanAges 6–99 - NCT05679921RecruitingPhase 2
Pazopanib, with or without pembrolizumab, for metastatic soft-tissue cancer
This Phase 2 trial tests pazopanib alone or together with pembrolizumab to slow or shrink metastatic soft-tissue sarcoma after prior chemotherapy. It may help some people by strengthening the anti-cancer effect compared with pazopanib by itself.
SeoulAges 20–80 - NCT06022159RecruitingPhase 2
Short radiation therapy for older adults with sarcoma
This trial tests a shorter, more convenient radiation schedule (hypofractionated) for older or fragile adults with soft tissue sarcoma in a limb or trunk. It aims to see if this approach is safe and effective before surgery.
BordeauxAges 65 years+ - NCT06087861RecruitingPhase 2
Short course radiation before sarcoma surgery
This trial tests a shorter course of radiation (just 5 days) before surgery for soft tissue sarcoma. The goal is to see if a brief, high-dose radiation schedule works as well as or better than the usual longer course—and may be more convenient for you.
Palo Alto, CaliforniaAges 18 years+ - NCT06500065Recruiting
Testing a new PET scan for soft tissue sarcoma
This study uses a special PET/CT scan (68Ga-DOTATATE) to see if it can better find soft tissue sarcomas. You will also have a standard PET/CT scan for comparison, and the results may help guide your treatment.
Columbus, OhioAges 18 years+ - NCT06506838RecruitingPhase 4
Anlotinib, chemo, and radiation before sarcoma surgery
This trial tests combining anlotinib (a targeted therapy), doxorubicin (chemotherapy), and radiation given before surgery to shrink high-grade soft tissue sarcomas. The goal is to make the tumor easier to remove and improve outcomes.
Guangzhou, GuangdongAges 18–75 - NCT06514313RecruitingPhase 2
Study of a drug combo for children with returning soft tissue sarcoma
This trial tests a combination of three drugs (VIM and VIT) for children and young adults whose soft tissue sarcoma has come back or not responded to previous treatments. The goal is to see if this new combination can help shrink or control the tumor.
Guangzhou, GuangdongAges 2–21 - NCT07032285RecruitingPhase 2
Cirtuvivint for advanced soft-tissue sarcomas
This trial tests a new drug called Cirtuvivint for people with certain advanced soft-tissue sarcomas that have grown recently. It aims to see if the drug can stop or slow tumor growth.
Madrid, MadridAges 16–70 - NCT02910895Recruiting
Test of lab-grown sarcoma samples to guide treatment research
This study uses tumor samples from soft tissue sarcoma to create lab models that researchers can test. It may help scientists better understand sarcoma and find more personalized treatment ideas for people like you.
AmsterdamAges 18 years+ - NCT06637007RecruitingPhase 2
Chidamide plus AK112 for advanced sarcoma after first treatment
This trial tests two new drugs (chidamide and AK112) together for people with advanced bone or soft tissue sarcoma that has not responded to standard first-line treatment. The goal is to see if this combination can shrink tumors or slow their growth.
Taiyuan, ShanxiAges 18–75 - NCT06062927Recruiting
Genes and scans predict response to immunotherapy and targeted therapy for advanced sarcoma
This trial is testing whether a combination of two drugs—a targeted therapy (surufatinib) and an immunotherapy (envafolimab)—can help people with advanced soft tissue sarcoma that has spread or cannot be removed by surgery. Researchers will also use a person's genetic information and scans to see if they can predict who will benefit the most.
Beijing, Beijing MunicipalityAges 18–75 - NCT06849986RecruitingPhase 2
Immunotherapy & AI for first-line soft tissue sarcoma
This trial tests a combination of immunotherapy (a treatment that helps your immune system attack cancer) and artificial intelligence (AI) technology as the first treatment for certain types of advanced soft tissue sarcoma. It aims to see if this approach can shrink tumors or stop them from growing better than current options.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06796881Recruiting
Comparison of two therapies for long-term low back pain
This study compares two hands-on treatments for people with chronic low back pain. One uses special tools to massage tight muscles, while the other uses gentle pressure on muscle knots. Both aim to help you move better and feel less pain.
CairoAges 25–45 - NCT07705334RecruitingPhase 1
Study of SHY-ONC6 for advanced solid tumors
This trial tests a new drug called SHY-ONC6 that targets and breaks down cancer cells. It's for people with advanced solid tumors that haven't responded to standard treatments.
Scottsdale, ArizonaAges 18 years+ - NCT05621668RecruitingPhase 1
First drug trial using engineered T-cells for sarcoma
This Phase 1 trial tests a new immune therapy made from your T-cells and engineered to target sarcoma tumors. It is designed to see if the treatment is safe and whether it can shrink advanced or metastatic soft tissue or bone sarcoma.
Houston, TexasAges 12 years+ - NCT04166006RecruitingPhase 2
Vaccine made from your tumor cells after surgery for rare cancers
This trial tests a personalized vaccine made from your own tumor material, aiming to lower the chance cancer returns after surgery. It is for people whose rare cancers have been removed completely and who have no standard treatment available after surgery.
Meldola, FCAges 18 years+ - NCT06743958Enrolling by invitation
Prehab for kids with leg bone or soft tissue sarcomas
This study tests whether a prehabilitation program (special exercises and support before cancer treatment) helps children and teens with leg sarcomas recover better. It aims to improve strength and mobility after treatment.
Munich, BavariaAges 6–18 - NCT06367075RecruitingPhase 2
Cadonilimab plus adriamycin for advanced soft tissue sarcoma
This trial tests a combination of two drugs—cadonilimab (a type of immunotherapy) and adriamycin (chemotherapy)—for adults with advanced soft tissue sarcoma that hasn't been treated before. The goal is to see if this combination helps shrink tumors or slow their growth.
Wuhan, HubeiAges 18–75 - NCT06114004RecruitingPhase 2
Selinexor plus gemcitabine for advanced soft-tissue sarcoma
This trial tests a combination of two drugs, selinexor and gemcitabine, for people with a type of soft-tissue sarcoma (leiomyosarcoma or malignant peripheral nerve sheath tumor) that has spread or cannot be surgically removed and has gotten worse despite at least one prior treatment. The goal is to see if this combination can help shrink or slow the cancer.
Santa Cruz de Tenerife, Canary IslandsAges 18–80 - NCT06760221Recruiting
Spotlight on bone cancer: SBRT plus surgery
This trial tests if giving a high dose of focused radiation (SBRT) before surgery can improve outcomes for people with aggressive soft tissue sarcoma in an arm or leg. You may be able to avoid chemotherapy and still have a good result.
Hangzhou, ZhejiangAges 18–80
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Common questions
- Are there clinical trials for soft tissue cancer?
- Yes. Clin2 currently lists 135 recruiting soft tissue cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a soft tissue cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a soft tissue cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.