Clinical trials
Soft Tissue Sarcoma clinical trials
Below are recruiting soft tissue sarcoma clinical trials, each written for real people, not researchers. We’re tracking 166 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06537596RecruitingPhase 1
Imaging test for soft tissue sarcoma and other tumors
This study tests an imaging agent that may help see tumors with a specific protein called PDGFR alpha. It may help doctors better understand your cancer and plan treatment.
Brisbane, QueenslandAges 18 years+ - NCT06498648RecruitingPhase 1/Phase 2
Abemaciclib with gemcitabine for soft tissue sarcoma
This trial tests whether adding the targeted drug abemaciclib to standard chemotherapy (gemcitabine) works better against certain soft tissue sarcomas. It is for people whose tumors have a normal Rb gene, which may help the drug work.
Houston, TexasAges 18 years+ - NCT06500065Recruiting
Testing a new PET scan for soft tissue sarcoma
This study uses a special PET/CT scan (68Ga-DOTATATE) to see if it can better find soft tissue sarcomas. You will also have a standard PET/CT scan for comparison, and the results may help guide your treatment.
Columbus, OhioAges 18 years+ - NCT06474676RecruitingPhase 1
Modified immune cell therapy for advanced sarcoma
This trial tests a new treatment using your own immune cells (TILs) that have been modified to attack sarcoma tumors. It is for people with advanced soft tissue or bone sarcoma who have already tried at least one other therapy.
Houston, TexasAges 12 years+ - NCT06409013Recruiting
Dye-guided surgery for sarcoma removal
This study tests whether using a special dye during surgery helps doctors see and remove sarcoma tumors more completely. It may help improve the chances that no cancer is left behind.
Rochester, MinnesotaAges 18 years+ - NCT06327477RecruitingPhase 1/Phase 2
A new type of radiation for newly diagnosed retroperitoneal sarcoma
This trial tests a new way of giving radiation called proton spatially fractionated radiotherapy (P-SFRT) combined with standard radiation for people with a type of sarcoma in the back of the belly. The goal is to see if this combination can treat the tumor more effectively.
Chicago, IllinoisAges 18 years+ - NCT06263231RecruitingPhase 3
Study of INT230-6 injection for soft tissue sarcoma
This study tests an experimental drug, INT230-6, injected directly into tumors, compared to the usual treatments for soft tissue sarcoma. It aims to see if the injection is safe and works better for people whose cancer has not responded to earlier treatments.
Los Angeles, CaliforniaAges 18 years+ - NCT06239272RecruitingPhase 1/Phase 2
Personalized treatment for NRSTS in children and young adults
This trial tests a personalized treatment plan for children and young adults with a type of soft tissue sarcoma (NRSTS). It uses a combination of surgery, targeted radiation, and two drugs (pazopanib and selinexor) to fight cancer while reducing side effects. The study is looking for people who have not been treated before for this sarcoma.
Atlanta, GeorgiaAges Up to 30 years - NCT03805022RecruitingPhase 3
Extra chemotherapy around surgery for high-risk soft-tissue sarcoma
This trial tests whether giving stronger chemotherapy before and/or after surgery helps people with high-risk, resectable soft-tissue sarcoma. It aims to lower the chance the cancer comes back by improving treatment around the time of the operation.
BordeauxAges 18 years+ - NCT06211257Recruiting
Digital info vs standard leaflets for advanced sarcoma
This trial is testing a digital tool (like videos or online info) to help people with advanced sarcoma understand their treatment better. It compares the digital tool to standard printed leaflets to see which improves understanding and wellbeing.
Lyon, Auvergne-Rhône-AlpesAges 18 years+ - NCT05296564RecruitingPhase 1/Phase 2
TCR cell therapy for NY-ESO-1 positive metastatic cancers
This study tests a customized immune-cell treatment made from your own T cells to attack cancers that have NY-ESO-1. It may help shrink tumors in people with metastatic or hard-to-treat cancer when other treatments have not worked.
JerusalemAges 18–70 - NCT05182164RecruitingPhase 2
Pembrolizumab plus cabozantinib for advanced sarcoma patients
This Phase 2 trial studies whether combining pembrolizumab and cabozantinib can control advanced sarcoma that can’t be removed by surgery and has grown or returned after standard treatment. It may help shrink tumors and improve outcomes in adults who have limited treatment options left.
BordeauxAges 18 years+ - NCT06129903Recruiting
Early psychiatric help for people with sarcoma
This study tests if getting a psychiatric consultation soon after a sarcoma diagnosis can improve mental health and quality of life. If you have a new sarcoma and need surgery at MSK, you may be able to join.
Basking Ridge, New JerseyAges 18 years+ - NCT06087861RecruitingPhase 2
Short course radiation before sarcoma surgery
This trial tests a shorter course of radiation (just 5 days) before surgery for soft tissue sarcoma. The goal is to see if a brief, high-dose radiation schedule works as well as or better than the usual longer course—and may be more convenient for you.
Palo Alto, CaliforniaAges 18 years+ - NCT06073067Recruiting
GRID therapy for extremity soft tissue sarcoma
This trial tests a special type of radiation called GRID therapy for soft tissue sarcomas in the arm or leg. It may be an option for people who have not had radiation to that area before and whose tumor was not completely removed by surgery.
Chapel Hill, North CarolinaAges 18 years+ - NCT06022159RecruitingPhase 2
Short radiation therapy for older adults with sarcoma
This trial tests a shorter, more convenient radiation schedule (hypofractionated) for older or fragile adults with soft tissue sarcoma in a limb or trunk. It aims to see if this approach is safe and effective before surgery.
BordeauxAges 65 years+ - NCT05950594RecruitingPhase 2
MRI and blood tests study in soft tissue sarcoma
This Phase 2 trial looks at how two test approaches (an MRI-based scan and blood tests) work in people with a larger, grade 2 or 3 soft tissue sarcoma. It may help researchers learn better ways to measure the disease and guide care.
Toronto, OntarioAges 18–100 - NCT02811523RecruitingPhase 1
Testing a lung procedure to treat sarcoma lung metastases
This early-phase study tests a special way to deliver medicine directly to the lungs (called IVLP) for sarcoma that has spread to both lungs. It aims to control lung metastases while reducing side effects, and it uses a plan that often includes surgery or focused radiation around the procedure.
TorontoAges birth–64 years - NCT05755113RecruitingPhase 2
Testing a drug injected into tumors for soft tissue sarcoma
This trial tests whether a medicine injected directly into a tumor can shrink or control advanced soft tissue sarcoma. It mainly looks for people whose tumors can be safely injected with a hand exam or ultrasound.
New York, New YorkAges 18 years+ - NCT05774275RecruitingPhase 1/Phase 2
Testing combined radiation, chemotherapy, and immunotherapy for high-risk sarcoma
This study tests whether giving radiation, chemotherapy, and immunotherapy together can control high-risk soft tissue sarcoma that is hard to remove or may come back after surgery. It may help by attacking cancer in different ways, including boosting the immune system.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05301283RecruitingPhase 2
Adaptive radiation therapy before surgery for soft-tissue sarcoma
This trial tests a personalized (“adaptive”) radiation plan before surgery for high-grade soft-tissue sarcoma that can be removed. It may help shrink the tumor and improve how well surgery can treat the cancer.
Tampa, FloridaAges 18 years+ - NCT05224934Recruiting
Radiation before surgery for retroperitoneal soft-tissue sarcoma
This trial tests giving a shorter, lower-dose radiation treatment before surgery for a retroperitoneal (deep belly/back space) soft-tissue sarcoma. The goal is to shrink or control the tumor and make surgery more effective and safe.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05526417Recruiting
Prehab program before treatment for deep leg soft tissue cancer
This trial tests an individualized “prehab” program (exercises and preparation before treatment) to improve recovery and surgical outcomes for adults with deep soft tissue sarcoma in the leg. It’s meant to help your body be as ready as possible for radiotherapy and surgery.
Scottsdale, ArizonaAges 18 years+ - NCT05333458RecruitingPhase 2
Atezolizumab plus selinexor for advanced alveolar soft tissue sarcoma
This Phase 2 trial tests whether combining atezolizumab with selinexor can slow or shrink advanced alveolar soft part sarcoma (ASPS) in people age 12 and older. It may help by improving the immune system’s ability to fight the cancer and stopping cancer cell growth signals.
Los Angeles, CaliforniaAges 12 years+
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Common questions
- Are there clinical trials for soft tissue sarcoma?
- Yes. Clin2 currently lists 166 recruiting soft tissue sarcoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a soft tissue sarcoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a soft tissue sarcoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.