Clinical trials
Soft Tissue Sarcoma clinical trials
Below are recruiting soft tissue sarcoma clinical trials, each written for real people, not researchers. We’re tracking 181 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07049848RecruitingPhase 2
Study of atezolizumab with chemo and radiation for high-risk sarcoma
This trial tests a combination of immunotherapy (atezolizumab), chemotherapy (doxorubicin), and radiation before and after surgery for people with high-risk soft tissue sarcoma in the arm, leg, or trunk. The goal is to see if this approach can improve outcomes.
Houston, TexasAges 18 years+ - NCT07052383RecruitingPhase 1
DIT309 for advanced bone and soft tissue sarcomas
This trial tests a new cell therapy called DIT309 for people with advanced bone or soft tissue sarcoma that hasn't responded to standard treatments. It aims to see if this therapy is safe and effective.
Shanghai, Shanghai MunicipalityAges 8 years+ - NCT07066982RecruitingPhase 1/Phase 2
CAR T cells targeting CD146 and HER2 for advanced sarcomas
This trial tests a new type of immunotherapy where your own immune cells are modified to find and attack sarcoma cells that carry markers called CD146 or HER2. It is for people with advanced sarcoma who have already tried standard treatments.
Beijing, Beijing MunicipalityAges 21–90 - NCT07071727Recruiting
Short course of radiation before surgery for soft tissue sarcoma
This trial tests whether a shorter course of radiation before surgery is effective for soft tissue sarcomas in certain locations. It aims to make treatment more convenient while maintaining good results.
AmsterdamAges 18 years+ - NCT07134192Recruiting
Using a dye to guide sarcoma surgery
This trial tests a special dye that helps surgeons see the edges of sarcoma tumors during surgery. It may help them remove all the cancer while saving healthy tissue.
Aarhus NAges 18 years+ - NCT07156565RecruitingPhase 1
Targeted radiation therapy for advanced sarcoma
This trial tests a new radioactive drug for people with advanced soft tissue sarcoma that has come back or not responded to prior treatment. The drug targets a protein found on sarcoma cells to deliver radiation directly to the tumor.
Los Angeles, CaliforniaAges 18 years+ - NCT07169344RecruitingPhase 2
Short course radiation before sarcoma surgery
This trial tests a shorter, 3-week course of radiation therapy (using protons or standard X-rays) given before surgery for localized soft tissue sarcoma. It aims to see if this approach is safe and effective for treating the tumor while reducing side effects.
BergenAges 18 years+ - NCT07173972RecruitingPhase 2
Proton radiation for inoperable soft tissue sarcoma
This trial studies a high-dose, shortened course of proton beam radiation for people with soft tissue sarcoma that cannot be removed by surgery. It aims to improve tumor control while reducing side effects.
BergenAges 18 years+ - NCT07222735RecruitingPhase 1
CAR T cells and radiation for children with sarcoma
This trial tests a combination of targeted radiation and special immune cells (CAR T cells) for children and young adults whose bone or soft tissue sarcoma has come back or not responded to standard treatments. The CAR T cells are made from your own blood cells and are designed to attack a protein called B7-H3 found on the sarcoma cells.
Memphis, TennesseeAges Up to 21 years - NCT07243626RecruitingPhase 2
Envafolimab plus chemo for advanced soft tissue sarcoma
This trial tests a new immunotherapy drug (envafolimab) combined with two chemotherapy drugs (doxorubicin and ifosfamide) for people with advanced soft tissue sarcoma who have not had prior treatment. The goal is to see if this combination is safe and effective.
Hanzhong, ZhejiangAges 18 years+ - NCT07283731RecruitingPhase 2
Testing zanzalintinib plus pembrolizumab for certain sarcomas
This trial is looking at whether a new combination of two drugs, zanzalintinib and pembrolizumab, can help people with certain types of advanced soft-tissue sarcoma that have not responded to other treatments. It aims to find out if the combination is safe and effective.
Houston, TexasAges 18 years+ - NCT07291297RecruitingPhase 2
Metformin plus standard therapy for soft tissue sarcoma
This trial tests adding metformin, a common diabetes drug, to the usual first cancer treatment for advanced soft tissue sarcoma. It may help the standard therapy work better.
Charlotte, North CarolinaAges 18 years+ - NCT02910895Recruiting
Test of lab-grown sarcoma samples to guide treatment research
This study uses tumor samples from soft tissue sarcoma to create lab models that researchers can test. It may help scientists better understand sarcoma and find more personalized treatment ideas for people like you.
AmsterdamAges 18 years+ - NCT02275286RecruitingPhase 1/Phase 2
Trabectedin plus radiation for select soft tissue sarcomas
This trial studies whether adding a chemotherapy medicine called trabectedin to targeted radiation can help control certain soft tissue sarcomas. It focuses on specific cancer types and locations, aiming to shrink tumors while keeping radiation safe for nearby healthy organs.
BordeauxAges 18 years+ - NCT02701153Recruiting
Short pre-surgery radiation for soft-tissue sarcoma
This trial tests a short course of radiation before surgery to shrink a soft-tissue sarcoma and make it easier to remove. It may help by improving how well the tumor can be removed, while studying safety and effectiveness for this cancer type.
Los Angeles, CaliforniaAges 18 years+ - NCT02789384Recruiting
Study of tumor markers to predict chemotherapy benefit in sarcoma
This study looks at stored tumor tissue (or takes a new biopsy) to measure specific tumor markers. Researchers want to see whether these markers match how well chemotherapy works before surgery for soft-tissue sarcoma.
BordeauxAges 18 years+ - NCT02811523RecruitingPhase 1
Testing a lung procedure to treat sarcoma lung metastases
This early-phase study tests a special way to deliver medicine directly to the lungs (called IVLP) for sarcoma that has spread to both lungs. It aims to control lung metastases while reducing side effects, and it uses a plan that often includes surgery or focused radiation around the procedure.
TorontoAges birth–64 years - NCT03138161RecruitingPhase 1/Phase 2
Testing three medicines for previously treated soft-tissue sarcoma
This trial tests trabectedin plus ipilimumab and nivolumab in people with advanced soft-tissue sarcoma that has already been treated. It aims to see how well this combination works and how safely it can be given.
Santa Monica, CaliforniaAges 18 years+ - NCT06968988RecruitingPhase 1
Three-drug combo for advanced soft tissue sarcoma
This trial tests a new combination of three drugs (zanzalintinib, ipilimumab, and nivolumab) for people with soft tissue sarcoma that has spread. The goal is to see if this combination can shrink or slow the cancer.
St Louis, MissouriAges 18 years+ - NCT07402577Recruiting
Pain and opioid use in young sarcoma survivors
This study looks at pain and opioid use in adolescents and young adults who have had sarcoma. It uses a smartphone app to track symptoms over 3 months to better understand cancer-related pain.
Buffalo, New YorkAges 12–70 - NCT07432932Recruiting
Personalized treatment before surgery for high-risk sarcoma
This trial tests a precision medicine approach by giving targeted therapy before surgery for high-risk soft tissue sarcoma. The goal is to see if matching treatment to your tumor's type can improve outcomes.
LondonAges 18 years+ - NCT07436364RecruitingEarly Phase 1
Ultrasound to monitor sarcoma response to radiation
This trial uses contrast-enhanced ultrasound to see how well soft tissue sarcoma responds to radiation therapy given before surgery. The goal is to find out if this imaging method can help doctors assess treatment effects earlier.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07501026RecruitingPhase 2
Testing a new radiation method before sarcoma surgery
This trial tests a new type of radiation called spatially fractionated radiation therapy (SFRT) given before surgery for large soft tissue sarcomas in the arm, leg, or trunk. The goal is to see if it helps shrink the tumor and improve treatment outcomes.
Hangzhou, ZhejiangAges 18–75 - NCT07502885Recruiting
Study of walking in children with bone or soft tissue tumors
This study looks at how children with certain bone or soft tissue tumors walk after orthopedic surgery. It aims to understand and improve their movement and recovery.
Memphis, TennesseeAges 5–20
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Common questions
- Are there clinical trials for soft tissue sarcoma?
- Yes. Clin2 currently lists 181 recruiting soft tissue sarcoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a soft tissue sarcoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a soft tissue sarcoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.