Clinical trials
Spasticity clinical trials
Below are recruiting spasticity clinical trials, each written for real people, not researchers. We’re tracking 155 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07501429RecruitingPhase 1
Shockwave therapy for arm spasticity after spinal cord injury
This trial tests whether shockwave therapy can reduce muscle tightness in the elbow and wrist caused by spinal cord injury. It may help make daily tasks like dressing or bathing easier.
West Orange, New JerseyAges 18 years+ - NCT07561359Enrolling by invitation
12-Week Home Exercise Program for Hereditary Spastic Paraplegia
This trial tests whether a guided 12-week strength and movement exercise program, done at home using your phone or computer, can improve walking ability and muscle strength in people with hereditary spastic paraplegia (a genetic condition that causes leg stiffness and weakness). The program is tailored to your current fitness level.
Porto Alegre, Rio Grande do SulAges 16–70 - NCT07264166Enrolling by invitation
Gene therapy trial for cerebral palsy and HIE
This trial tests a gene therapy given as a nose spray for people with cerebral palsy or HIE. It aims to see if the treatment is safe and helps improve movement over two years.
Monterrey, Nuevo LeónAges 2–65 - NCT05447299Enrolling by invitation
Muscle and spasticity testing using MRI modeling
This study uses an MRI scan and movement measurements to better understand muscle tightness (spasticity) in children with cerebral palsy. It may help researchers improve how spasticity is evaluated and modeled to support future treatments.
StockholmAges 5–18 - NCT03384927Enrolling by invitation
Dairy intake study for muscle stiffness in spasticity
This trial looks at whether eating dairy can reduce spasticity, or muscle stiffness/tightness. It’s testing dairy as an add-on by comparing your muscle symptoms and treatment goals during the study.
Glostrup MunicipalityAges Any age - NCT07639060Recruiting
Pain Relief Study Using Freezing Nerve Treatment
This study watches how well a freezing procedure works for chronic pain over 6 to 12 months. Your doctor thinks this procedure could help your pain, and the study simply tracks your recovery through questionnaires to help doctors understand if it works.
Old Saybrook, ConnecticutAges 18 years+ - NCT07108920Recruiting
Balance and Botox for Stiff Knee Gait
This study tests whether botulinum toxin (Botox) injections into the rectus femoris thigh muscle can improve balance and walking in people with a stiff knee gait (a common problem after stroke, brain injury, or multiple sclerosis).
Héricourt, Nord Franche-ComtéAges 18 years+ - NCT04799288RecruitingPhase 1/Phase 2
Teriflunomide for HTLV-1 spinal cord stiffness and weakness
This early-phase trial tests whether teriflunomide can help people with HTLV-1 associated myelopathy (HAM) or tropical spastic paraparesis (TSP). It also checks safety and how well the treatment can be followed over time.
Bethesda, MarylandAges 18–120 - NCT07686809Recruiting
Leg therapy for children with one-sided weakness
This study tests a new leg exercise program to help children with hemiplegia walk better. The therapy may improve balance and movement in the affected leg.
CairoAges 6–8 - NCT07287215Recruiting
Motor imagery and daily function in diplegic cerebral palsy
This study tests whether imagining movements (motor imagery) can help improve everyday skills like walking and playing in children with diplegic cerebral palsy. It compares the effects of motor imagery training with standard physical therapy.
BingoelAges 5–18 - NCT03047369Recruiting
Myelin brain disorder research biobank for samples and data
This study collects brain-related medical information and biological samples to help researchers better understand leukodystrophies and other white-matter brain disorders. It may help future diagnosis and treatments by building a valuable “biobank” of patient data and samples.
Los Angeles, CaliforniaAges Any age - NCT03096197Recruiting
Exoskeleton and spinal stimulation for long-term spinal cord injury
This trial tests whether an external walking-assist device (an exoskeleton) plus targeted spinal cord stimulation can help people with long-term spinal cord injury. It may be designed for wheelchair users who meet specific nerve function and bone health requirements.
West Orange, New JerseyAges 18–65 - NCT04596852Recruiting
Testing a new stiffness and spasticity measuring method in children
This study checks whether a special device can reliably measure muscle stiffness and spasticity (tight, overactive muscles) in children. It includes children with cerebral palsy and healthy children to compare measurements and improve accuracy.
Saint-Fargeau-PonthierryAges 7–18 - NCT04630873RecruitingPhase 1
Botox dilution options for walking in hemiplegic gait
This Phase 1 study tests whether using a lower or higher dilution of Botox injections improves walking in people with hemiplegic gait. The goal is to see which dilution works better (and is safe) for walking and leg stiffness.
IoanninaAges 18 years+ - NCT04975646Recruiting
Goal-setting tool for upper-arm spasticity treatment
This study looks at whether a structured goal-setting approach helps measure and improve treatment for stiff, tight upper-arm muscles after a stroke. It tests how well patients’ (or caregivers’) goals can be tracked when receiving or considering botulinum toxin (BTX-A).
LjubljanaAges 18 years+ - NCT05094362Recruiting
Training to reduce stiff leg reflexes after spinal cord injury
This study tests a special training approach designed to calm overactive leg reflexes (spasticity) after spinal cord injury. If you qualify, you may do structured walking/reflex training to see whether your leg reflexes and movement improve.
Charleston, South CarolinaAges 18 years+ - NCT05315726Recruiting
Vibration therapy to reduce stiffness after stroke
This trial studies whether regular muscle vibration can reduce post-stroke muscle stiffness and improve how the brain and nerves adapt. If you’re in the right stage after stroke, it may help improve arm and hand movement.
Chalon-sur-SaôneAges 18 years+ - NCT05497609Recruiting
Study of tiny muscle changes in children with cerebral palsy
This study follows children with cerebral palsy (and sometimes acquired brain injury) to learn how the muscles look and change over time at a very small, microscopic level. The results may help researchers better understand what’s happening in the muscles and guide future treatments.
StockholmAges 2–18 - NCT05506228Recruiting
Muscle biopsy during surgery study in brain injury conditions
This study looks at how muscles are affected in children and teens with cerebral palsy or an acquired brain injury. Researchers take a small muscle tissue sample during surgery that you were already having for medical reasons, to better understand muscle changes.
StockholmAges 2–18 - NCT05506085Recruiting
Brain stimulator study for voice spasms with tremor
This trial studies a brain stimulation approach for a specific voice disorder that can include tremor. It aims to better understand how well the treatment works and how to use it more effectively while carefully checking safety with awake procedures.
Indianapolis, IndianaAges 18–70 - NCT05518565Recruiting
Study muscle changes in people with cerebral palsy
This study looks at how muscles work in the body in people with cerebral palsy or an acquired brain injury. It may help researchers understand muscle structure and changes over time, which could guide future treatments.
StockholmAges 2–18 - NCT05571033Recruiting
Training the ankle reflex in adults with spastic cerebral palsy
This study tests a method to retrain a reflex in the ankle to help reduce muscle tightness and improve movement in adults with spastic cerebral palsy. You would do controlled practice during the study while your usual medical care stays stable.
White Plains, New YorkAges 18 years+ - NCT05593887Recruiting
Compare three surgeries for late hip dislocation in non-walking children with CP
This trial looks at which surgery works best for children with cerebral palsy who do not walk and have a neglected, deformed hip that has dislocated for a long time. The goal is to compare outcomes after three different hip procedures.
Cairo, AbbasiaAges Any age - NCT05674604Recruiting
Cryoneurolysis to reduce knee and shoulder pain in hospital
This trial tests whether a procedure called cryoneurolysis can reduce pain in people recovering from certain recent brain or nerve injuries (like stroke or traumatic brain injury). It may be helpful if you have either hemiplegic shoulder pain or knee pain from osteoarthritis while you’re in inpatient rehab.
Victoria, British ColumbiaAges 18–80
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Common questions
- Are there clinical trials for spasticity?
- Yes. Clin2 currently lists 155 recruiting spasticity studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a spasticity trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a spasticity trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.